Now showing items 1-20 of 1278

    • 15-Deoxy-Δ-12, 14-prostaglandin J2 acts cooperatively with prednisolone to reduce TGF-β-induced pro-fibrotic pathways in human osteoarthritis fibroblasts 

      Vaamonde-García, Carlos; Malaise, Olivier; Charlier, Edith; Deroyer, Céline; Neuville, Sophie; Gillet, Philippe; Kurth, William; Meijide-Faílde, Rosa; Malaise, Michel G.; De Seny, Dominique (Elsevier, 2019-03-29)
      [Abstract] Abstract Background/aims: Synovial fibrosis is a pathological process that is observed in several musculoskeletal disorders and characterized by the excessive deposition of extracellular matrix, as well as cell ...
    • 20 años de investigación científica de la revista Retos, nuevas tendencias en educación física, deportes y recreación: análisis bibliométrico 

      Ramos-Álvarez, Olivier; García-Romero, Cristina; Arufe-Giráldez, Víctor (Federación Española de Asociaciones de Docentes de Educación Física (FEADEF), 2024-05-01)
      [Resumen] El objetivo del presente estudio fue realizar un análisis bibliométrico de los documentos publicados en la revista Retos, nuevas tendencias en Educación Física, Deportes y Recreación, desde 2002 a 2022. Para ello, ...
    • 2019 EACTS Expert Consensus on long-term mechanical circulatory support 

      Potapov, Evgenij V.; Antonides, Christiaan; Crespo-Leiro, María Generosa; Combes, Alain; Färber, Gloria; Hannan, Margaret M.; Kukucka, Marian; De Jonge, Nicolaas; Loforte, Antonio; Lund, Lars H.; Mohacsi, Paul; Morshuis, Michiel; Netuka, Ivan; Özbaran, Mustafa; Pappalardo, Federico; Scandroglio, Anna Mara; Schweiger, Martin; Tsui, Steven; Zimpfer, Daniel; Gustafsson, Fin (Oxford, 2019-05-17)
      [Abstract] Long-term mechanical circulatory support (LT-MCS) is an important treatment modality for patients with severe heart failure. Different devices are available, and many—sometimes contradictory—observations regarding ...
    • 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 

      McDonagh, Theresa A.; Metra, Marco; Adamo, Marianna; Gardner, Roy S.; Baumbach, Andreas; Böhm, Michael; Burri, Haram; Butler, Javed; Čelutkienė, Jelena; Chioncel, Ovidiu; Cleland, John G.F.; Crespo-Leiro, María Generosa; Farmakis, Dimitrios; Gilard, Martine; Heymans, Stephane; Hoes, Arno W.; Jaarsma, Tiny; Jankowska, Ewa A.; Lainscak, Mitja; Lam, Carolyn S.P.; Lyon, Alexander R.; McMurray, John J.V.; Mebazaa, Alexandre; Mindham, Richard; Muneretto, Claudio; Piepoli, Massimo Francesco; Price, Susanna; Rosano, Giuseppe M.C.; Ruschitzka, Frank; Skibelund, Anne Kathrine (Oxford Academic, 2023-10-01)
    • 3, 3′, 5-triiodo-L-thyronine increases in vitro chondrogenesis of mesenchymal stem cells from human umbilical cord stroma through SRC2 

      Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Lesende-Rodríguez, Iván; Mateos, Jesús; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Arufe, M.C. (Wiley, 2016-07-08)
      [Abstract] Our group focuses on the study of mesenchymal stem cells (MSCs) from human umbilical cord stroma or Warthońs jelly and their directed differentiation toward chondrocyte-like cells capable of regenerating damaged ...
    • A 3-biomarker 2-point-based risk stratification strategy in acute heart failure 

      Álvarez-García, Jesús; García-Osuna, Álvaro; Vives-Borrás, Miquel; Ferrero-Gregori, Andreu; Martínez-Sellés, Manuel; Vázquez, Rafael; González-Juanatey, J.R.; Rivera, Miguel; Segovia-Cubero, Javier; Pascual-Figal, Domingo A.; Bover-Freire, Ramón; Bascompte, Ramón; Delgado, Juan; Grau Sepúlveda, Andrés; Bardají, Alfredo; Pérez-Villa, Félix; Zamorano, José Luis; Crespo-Leiro, María Generosa; Sánchez, Pedro Luis; Ordóñez-Llanos, Jordi; Cinca Cuscullola, Juan (Frontiers, 2021-10-22)
      [Abstract] Introduction and Objectives: Most multi-biomarker strategies in acute heart failure (HF) have only measured biomarkers in a single-point time. This study aimed to evaluate the prognostic yielding of NT-proBNP, ...
    • A clinical model including protein biomarkers predicts radiographic knee osteoarthritis: a prospective study using data from the Osteoarthritis Initiative 

      Lourido Salas, Lucía María; Balboa-Barreiro, Vanesa; Ruiz-Romero, Cristina; Rego-Pérez, Ignacio; Camacho Encina, María; Paz González, Rocío; Calamia, Valentina; Oreiro, Natividad; Nilsson, Peter; Blanco García, Francisco J (Elsevier, 2021-04-30)
    • A combined transcriptomic and genomic analysis identifies a gene signature associated with the response to anti-TNF therapy in rheumatoid arthritis 

      Aterido, Adriá; Cañete, Juan D.; Tornero, Jesús; Blanco García, Francisco J; Fernández-Gutiérrez, Benjamín; Pérez, Carolina; Alperi-López, Mercedes; Olivé, Alex; Corominas, Héctor; Martínez-Taboada, Víctor; González, Isidoro; Fernández-Nebro, Antonio; Erra, Alba; López-Lasanta, María; López-Corbeto, Mireia; Palau, Núria; Juliá, Antonio; Marsal, Sara (Frontiers, 2019-07-02)
      [Abstract] Background: Rheumatoid arthritis (RA) is the most frequent autoimmune disease involving the joints. Although anti-TNF therapies have proven effective in the management of RA, approximately one third of patients ...
    • A Comparative Study of Doppler Ultrasound Against Temporal Artery Biopsy in the Diagnosis of Giant Cell Arteritis 

      González Porto, Sara Alicia; Silva-Díaz, María T.; Reguera Arias, Ana; Pombo-Otero, Jorge; González Rodríguez, Alba; Valero Gasalla, Javier; De-Toro, Javier (Elsevier, 2020-08-13)
      [Abstract] Background. Giant cell arteritis (GCA) is a vasculitis that affects medium- and large-sized arteries. Temporal artery biopsy is the gold standard for diagnosis. In view of the high demand for temporal biopsies, ...
    • A comprehensive characterization of acute heart failure with preserved versus mildly reduced versus reduced ejection fraction - insights from the ESC-HFA EORP Heart Failure Long-Term Registry 

      Kaplon-Cieslicka, Agnieszka; Benson, Lina; Chioncel, Ovidiu; Crespo-Leiro, María Generosa; Coats, Andrew J.S.; Anker, Stefan; Filippatos, Gerasimos; Ruschitzka, Frank; Hage, Camilla; Drozdz, Jaroslaw; Seferovic, Petar; Rosano, Giuseppe M.C.; Piepoli, Massimo; Mebazaa, Alexandre; McDonagh, Theresa; Lainscak, Mitja; Savarese, Gianluigi; Ferrari, Roberto; Maggioni, Aldo P.; Lund, Lars H. (Wiley, 2021-12-27)
      [Abstract] Aims: To perform a comprehensive characterization of acute heart failure (AHF) with preserved (HFpEF), versus mildly reduced (HFmrEF) versus reduced ejection fraction (HFrEF). Methods and results: Of 5951 ...
    • A Computational Model of Cuneothalamic Projection Neurons 

      Sánchez Vila, Eduardo; Barro Ameneiro, Senén; Mariño Alfonso, Xurxo; Canedo Lamas, Antonio (Taylor and Francis, 2003)
      [Abstract] The dorsal column nuclei, cuneatus and gracilis, play a fundamental role in the processing and integration of somesthetic ascending information. Intracellular and patch-clamp recordings obtained in cat in vivo ...
    • A Didactic Unit for the Evaluation of the Use of Assistive Technology for Access to Computers in Occupational Therapy 

      Pousada, Thais; Jiménez, Estíbaliz; Díez, Emiliano (Wolters Kluwer, 2021-11-19)
      [Abstract] Assistive technology (AT) is an umbrella term that refers to different devices that facilitate the performance of activity for people. Future occupational therapists (OT) must acquire specific competencies to ...
    • A Framework for a New Approach to Empower Users Through Low-Cost and Do-It-Yourself Assistive Technology 

      Pousada, Thais; Garabal-Barbeira, Jessica; Porto Trillo, Patricia; Vilar Figueira, Olalla; Novo Díaz, Cristina; Pereira-Loureiro, Javier (MDPI, 2021-03-16)
      [Abstract] Background: Assistive Technology (AT) refers to “assistive products and related systems and services developed for people to maintain or improve functioning and thereby to promote well-being”. Improving the ...
    • A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis 

      Torices, Silvia; Juliá, Antonio; Muñoz, Pedro; Varela, Ignacio; Balsa, Alejandro; Marsal, Sara; Fernández-Nebro, Antonio; Blanco García, Francisco J; López-Hoyos, Marcos; Martínez-Taboada, Víctor; Fernández-Luna, José L. (Springer, 2016-10-04)
      [Abstract] Background. Toll-like receptor (TLR) family members are key players in inflammation. TLR10 has been poorly studied in chronic inflammatory disorders, and its clinical relevance in rheumatoid arthritis (RA) is ...
    • A Meta-Analysis of Genome-Wide Association Studies Identifies Novel Variants Associated with Osteoarthritis of the Hip 

      Evangelou, Evangelos; Kerkhof, Hanneke J.; Styrkarsdottir, Unnur; Ntzani, Evangelia E.; Bos, Steffan D.; Esko, Tonu; Evans, Daniel S.; Metrustry, Sarah; Panoutsopoulou, Kalliope; Ramos, Yolande F. M.; Thorleifsson, Gudmar; Tsilidis, Konstantinos K.; Arden, Nigel; Aslam, Nadim; Bellamy, Nicholas; Birrell, Fraser; Blanco García, Francisco J; Carr, Andrew; Chapman, Kay; Day-Williams, Aaaron G.; Deloukas, Panos; Doherty, Michael; Engström, Gunnar; Helgadottir, Hafdis T.; Hofman, Albert; Ingvarsson, Thorvaldur; Jonsson, Helgi; Keis, Aime; Keurentjes, J. Christiaan; Kloppenburg, Margreet; Lind, Penelope A.; McCaskie, Andrew; Martin, Nicholas G.; Milani, Lili; Montgomery, Grant W.; Nelissen, Rob G.H.H.; Nevitt, Michael C.; Nilsson, Peter M.; Ollier, William E.R.; Parimi, Neeta; Rai, Ashok; Ralston, Stuart H.; Reed, Mike R.; Riancho, José A.; Rivadeneira, Fernando; Rodríguez-Fontenla, Cristina; Southam, Lorraine; Thorsteindottir, Unnur; Tsezou, Aspasia; Wallis, Gillian A.; Wilkinson, J. Mark; González, Antonio; Lane, Nancy E.; Lohmander, L. Stefan; Loughlin, John; Metspalu, Andres; Uitterlinden, André G.; Jonsdottir, Ingileif; Stefansson, Kari; Slagboom, P. Eline; Zeggini, Eleftheria; Meulebelt, Ingrid; Ionnidis, John P.A.; Spector, Tim D.; van Meurs, Joyce B.J.; Valdes, Ana M. (BMJ, 2013-08-29)
      [Abstract] OBJECTIVES: Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies ...
    • A model for prediction of in-hospital mortality in patients with subarachnoid hemorrhage 

      Mourelo-Fariña, Mónica; Pértega-Díaz, Sonia; Galeiras, Rita (Springer, 2020-07-15)
      [Abstract] Background: Despite being a rare cause of stroke, spontaneous subarachnoid hemorrhage (SAH) is associated with high mortality rates. The prediction models that are currently being used on SAH patients are ...
    • A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment 

      Gallego-Fábrega, Cristina; Temprano-Sagrera, Gerard; Cárcel-Márquez, Jara; Muiño, Elena; Cullel, Natalia; Lledós, Miquel; Llucià-Carol, Laia; Martín-Campos, Jesús M.; Sobrino, Tomás; Castillo, José; Millán, Mónica; Muñoz-Narbona, Lucía; López-Cancio Martínez, Elena; Ribó, Marc; Álvarez-Sabín, José; Jiménez-Conde, Jordi; Roquer, Jaume; Tur, Silvia; Obach, Victor; Arenillas, Juan; Segura, Tomás; Serrano-Heras, Gemma; Martí-Fàbregas, Joan; Freijo Guerrero, María del Mar; Moniche Álvarez, Francisco; Castellanos, María del Mar; Morrison, Alana C.; Smith, Nicholas L.; de Vries, Paul S.; Fernández-Cadenas, Israel; Sabater-Lleal, María (Elsevier, 2023-12-15)
      [Abstract] Background: Thrombolytic recombinant tissue plasminogen activator (r-tPA) treatment is the only pharmacologic intervention available in the ischemic stroke acute phase. This treatment is associated with an ...
    • A new scenario in metastatic renal cell carcinoma: a SOG‑GU consensus 

      Vázquez Estévez, Sergio; Anido Herranz, Urbano; Lázaro Quintela, Martín; Fernández Calvo, Ovidio; Fernández-Núñez, Natalia; Dios Álvarez, N. de; Varela, V.; Campos Balea, B.; Agraso, S.; Areses, M. C.; Iglesias, L.; Blanco, Moisés; Maciá, S.; Antón-Aparicio, Luis M. (Springer, 2020-02-15)
      [Abstract] Background This article describes and compares approved targeted therapies and the newer immunotherapy agents. Materials and methods This article especially performs an in-depth review of currently available ...
    • A non-secreting pituitary adenoma that changed to a prolactinoma 

      Santiago-Vázquez, Cristina; Palacios-Paino, Nuria; Cordido, Fernando (MDPI, 2024-07-04)
      [Abstract] Pituitary adenomas (PAs) are the third most common brain tumors in adults right after meningiomas and gliomas. Taking into account their hormonal activity in vivo, they can be divided in functioning PAs, which ...
    • A novel procedure for protein extraction from formalin-fixed paraffin-embedded tissues 

      Rodríguez-Rigueiro, Teresa; Valladares-Ayerbes, Manuel; Haz, Mar; Blanco, Moisés; Aparicio Gallego, Guadalupe; Fernández-Puente, Patricia; Blanco García, Francisco J; Lorenzo-Patiño, María J.; Antón-Aparicio, Luis M.; Figueroa, Angélica (Wiley, 2011-05-18)
      [Abstract] Most of the archived pathological specimens in hospitals are kept as formalin-fixed paraffin-embedded tissues (FFPE) for long-term preservation. Up to now, these samples are only used for immunohistochemistry ...