Skip navigation
  •  Inicio
  • UDC 
    • Cómo depositar
    • Políticas do RUC
    • FAQ
    • Dereitos de Autor
    • Máis información en INFOguías UDC
  • Percorrer 
    • Comunidades
    • Buscar por:
    • Data de publicación
    • Autor
    • Título
    • Materia
  • Axuda
    • español
    • Gallegan
    • English
  • Acceder
  •  Galego 
    • Español
    • Galego
    • English
  
Ver ítem 
  •   RUC
  • Facultade de Ciencias da Saúde
  • Investigación (FCS)
  • Ver ítem
  •   RUC
  • Facultade de Ciencias da Saúde
  • Investigación (FCS)
  • Ver ítem
JavaScript is disabled for your browser. Some features of this site may not work without it.

A Meta-Analysis of Genome-Wide Association Studies Identifies Novel Variants Associated with Osteoarthritis of the Hip

Thumbnail
Ver/abrir
Evangelou_Metaanalysis.pdf (675.4Kb)
Evangelou_Metaanalysis_Suppl.pdf - Supplementary data (670.2Kb)
Use este enlace para citar
http://hdl.handle.net/2183/25302
Atribución-NoComercial 3.0 España
A non ser que se indique outra cousa, a licenza do ítem descríbese como Atribución-NoComercial 3.0 España
Coleccións
  • Investigación (FCS) [1295]
Metadatos
Mostrar o rexistro completo do ítem
Título
A Meta-Analysis of Genome-Wide Association Studies Identifies Novel Variants Associated with Osteoarthritis of the Hip
Autor(es)
Evangelou, Evangelos
Kerkhof, Hanneke J.
Styrkarsdottir, Unnur
Ntzani, Evangelia E.
Bos, Steffan D.
Esko, Tonu
Evans, Daniel S.
Metrustry, Sarah
Panoutsopoulou, Kalliope
Ramos, Yolande F. M.
Thorleifsson, Gudmar
Tsilidis, Konstantinos K.
Arden, Nigel
Aslam, Nadim
Bellamy, Nicholas
Birrell, Fraser
Blanco García, Francisco J
Carr, Andrew
Chapman, Kay
Day-Williams, Aaaron G.
Deloukas, Panos
Doherty, Michael
Engström, Gunnar
Helgadottir, Hafdis
Hofman, Albert
Ingvarsson, Thorvaldur
Jonsson, Helgi
Keis, Aime
Keurentjes, J. Christiaan
Kloppenburg, Margreet
Lind, Penelope A.
McCaskie, Andrew
Martin, Nicholas G.
Milani, Lili
Montgomery, Grant W.
Nelissen, Rob G.H.H.
Nevitt, Michael C.
Nilsson, Peter M.
Ollier, William E.R.
Parimi, Neeta
Rai, Ashok
Ralston, Stuart H.
Reed, Mike R.
Riancho, José A.
Rivadeneira, Fernando
Rodríguez-Fontenla, Cristina
Southam, Lorraine
Thorsteinsdottir, Unnur
Tsezou, Aspasia
Wallis, Gillian A.
Wilkinson, J. Mark
González, Antonio
Lane, Nancy E.
Lohmander, L. Stefan
Loughlin, John
Metspalu, Andres
Uitterlinden, André G.
Jonsdottir, Ingileif
Stefansson, Kari
Slagboom, Pieternella
Zeggini, Eleftheria
Meulebelt, Ingrid
Ioannidis, John P.A.
Spector, Tim D.
van Meurs, Joyce
Valdes, Ana M.
Data
2013-08-29
Cita bibliográfica
Evangelou E, Kerkhof HJ, Styrkarsdottir U, Ntzani EE, Bos SD, Esko T, et al. A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Ann Rheum Dis. 2014;73(12): 2130-2136
Resumo
[Abstract] OBJECTIVES: Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on European subjects. METHODS: We performed a two-stage meta-analysis on more than 78,000 participants. In stage 1, we synthesised data from eight GWAS whereas data from 10 centres were used for 'in silico' or 'de novo' replication. Besides the main analysis, a stratified by sex analysis was performed to detect possible sex-specific signals. Meta-analysis was performed using inverse-variance fixed effects models. A random effects approach was also used. RESULTS: We accumulated 11,277 cases of radiographic and symptomatic hip OA. We prioritised eight single nucleotide polymorphism (SNPs) for follow-up in the discovery stage (4349 OA cases); five from the combined analysis, two male specific and one female specific. One locus, at 20q13, represented by rs6094710 (minor allele frequency (MAF) 4%) near the NCOA3 (nuclear receptor coactivator 3) gene, reached genome-wide significance level with p=7.9×10(-9) and OR=1.28 (95% CI 1.18 to 1.39) in the combined analysis of discovery (p=5.6×10(-8)) and follow-up studies (p=7.3×10(-4)). We showed that this gene is expressed in articular cartilage and its expression was significantly reduced in OA-affected cartilage. Moreover, two loci remained suggestive associated; rs5009270 at 7q31 (MAF 30%, p=9.9×10(-7), OR=1.10) and rs3757837 at 7p13 (MAF 6%, p=2.2×10(-6), OR=1.27 in male specific analysis). CONCLUSIONS: Novel genetic loci for hip OA were found in this meta-analysis of GWAS.
Palabras chave
Epidemiology
Gene polymorphism
Osteoarthritis
 
Versión do editor
http://dx.doi.org/10.1136/annrheumdis-2012-203114
Dereitos
Atribución-NoComercial 3.0 España
ISSN
0003-4967

Listar

Todo RUCComunidades e colecciónsPor data de publicaciónAutoresTítulosMateriasGrupo de InvestigaciónTitulaciónEsta colecciónPor data de publicaciónAutoresTítulosMateriasGrupo de InvestigaciónTitulación

A miña conta

AccederRexistro

Estatísticas

Ver Estatísticas de uso
Sherpa
OpenArchives
OAIster
Scholar Google
UNIVERSIDADE DA CORUÑA. Servizo de Biblioteca.    DSpace Software Copyright © 2002-2013 Duraspace - Suxestións