Browsing Investigación (FCS) by Title

Now showing items 6-25 of 1289

    • A 3-biomarker 2-point-based risk stratification strategy in acute heart failure 

      Álvarez-García, Jesús; García-Osuna, Álvaro; Vives-Borrás, Miquel; Ferrero-Gregori, Andreu; Martínez-Sellés, Manuel; Vázquez, Rafael; González-Juanatey, J.R.; Rivera, Miguel; Segovia-Cubero, Javier; Pascual-Figal, Domingo A.; Bover-Freire, Ramón; Bascompte, Ramón; Delgado, Juan; Grau Sepúlveda, Andrés; Bardají, Alfredo; Pérez-Villa, Félix; Zamorano, José Luis; Crespo-Leiro, María Generosa; Sánchez, Pedro Luis; Ordóñez-Llanos, Jordi; Cinca Cuscullola, Juan (Frontiers, 2021-10-22)
      [Abstract] Introduction and Objectives: Most multi-biomarker strategies in acute heart failure (HF) have only measured biomarkers in a single-point time. This study aimed to evaluate the prognostic yielding of NT-proBNP, ...

    • A clinical model including protein biomarkers predicts radiographic knee osteoarthritis: a prospective study using data from the Osteoarthritis Initiative 

      Lourido Salas, Lucía María; Balboa-Barreiro, Vanesa; Ruiz-Romero, Cristina; Rego-Pérez, Ignacio; Camacho Encina, María; Paz González, Rocío; Calamia, Valentina; Oreiro, Natividad; Nilsson, Peter; Blanco García, Francisco J (Elsevier, 2021-04-30)

    • A combined transcriptomic and genomic analysis identifies a gene signature associated with the response to anti-TNF therapy in rheumatoid arthritis 

      Aterido, Adriá; Cañete, Juan D.; Tornero, Jesús; Blanco García, Francisco J; Fernández-Gutiérrez, Benjamín; Pérez, Carolina; Alperi-López, Mercedes; Olivé, Alex; Corominas, Héctor; Martínez-Taboada, Víctor; González, Isidoro; Fernández-Nebro, Antonio; Erra, Alba; López-Lasanta, María; López-Corbeto, Mireia; Palau, Núria; Juliá, Antonio; Marsal, Sara (Frontiers, 2019-07-02)
      [Abstract] Background: Rheumatoid arthritis (RA) is the most frequent autoimmune disease involving the joints. Although anti-TNF therapies have proven effective in the management of RA, approximately one third of patients ...

    • A Comparative Study of Doppler Ultrasound Against Temporal Artery Biopsy in the Diagnosis of Giant Cell Arteritis 

      González Porto, Sara Alicia; Silva-Díaz, María T.; Reguera Arias, Ana; Pombo-Otero, Jorge; González Rodríguez, Alba; Valero Gasalla, Javier; De-Toro, Javier (Elsevier, 2020-08-13)
      [Abstract] Background. Giant cell arteritis (GCA) is a vasculitis that affects medium- and large-sized arteries. Temporal artery biopsy is the gold standard for diagnosis. In view of the high demand for temporal biopsies, ...

    • A comprehensive characterization of acute heart failure with preserved versus mildly reduced versus reduced ejection fraction - insights from the ESC-HFA EORP Heart Failure Long-Term Registry 

      Kaplon-Cieslicka, Agnieszka; Benson, Lina; Chioncel, Ovidiu; Crespo-Leiro, María Generosa; Coats, Andrew J.S.; Anker, Stefan; Filippatos, Gerasimos; Ruschitzka, Frank; Hage, Camilla; Drozdz, Jaroslaw; Seferovic, Petar; Rosano, Giuseppe M.C.; Piepoli, Massimo; Mebazaa, Alexandre; McDonagh, Theresa; Lainscak, Mitja; Savarese, Gianluigi; Ferrari, Roberto; Maggioni, Aldo P.; Lund, Lars H. (Wiley, 2021-12-27)
      [Abstract] Aims: To perform a comprehensive characterization of acute heart failure (AHF) with preserved (HFpEF), versus mildly reduced (HFmrEF) versus reduced ejection fraction (HFrEF). Methods and results: Of 5951 ...

    • A Computational Model of Cuneothalamic Projection Neurons 

      Sánchez Vila, Eduardo; Barro Ameneiro, Senén; Mariño Alfonso, Xurxo; Canedo Lamas, Antonio (Taylor and Francis, 2003)
      [Abstract] The dorsal column nuclei, cuneatus and gracilis, play a fundamental role in the processing and integration of somesthetic ascending information. Intracellular and patch-clamp recordings obtained in cat in vivo ...

    • A Didactic Unit for the Evaluation of the Use of Assistive Technology for Access to Computers in Occupational Therapy 

      Pousada, Thais; Jiménez, Estíbaliz; Díez, Emiliano (Wolters Kluwer, 2021-11-19)
      [Abstract] Assistive technology (AT) is an umbrella term that refers to different devices that facilitate the performance of activity for people. Future occupational therapists (OT) must acquire specific competencies to ...

    • A Framework for a New Approach to Empower Users Through Low-Cost and Do-It-Yourself Assistive Technology 

      Pousada, Thais; Garabal-Barbeira, Jessica; Porto Trillo, Patricia; Vilar Figueira, Olalla; Novo Díaz, Cristina; Pereira-Loureiro, Javier (MDPI, 2021-03-16)
      [Abstract] Background: Assistive Technology (AT) refers to “assistive products and related systems and services developed for people to maintain or improve functioning and thereby to promote well-being”. Improving the ...

    • A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis 

      Torices, Silvia; Juliá, Antonio; Muñoz, Pedro; Varela, Ignacio; Balsa, Alejandro; Marsal, Sara; Fernández-Nebro, Antonio; Blanco García, Francisco J; López-Hoyos, Marcos; Martínez-Taboada, Víctor; Fernández-Luna, José L. (Springer, 2016-10-04)
      [Abstract] Background. Toll-like receptor (TLR) family members are key players in inflammation. TLR10 has been poorly studied in chronic inflammatory disorders, and its clinical relevance in rheumatoid arthritis (RA) is ...

    • A Meta-Analysis of Genome-Wide Association Studies Identifies Novel Variants Associated with Osteoarthritis of the Hip 

      Evangelou, Evangelos; Kerkhof, Hanneke J.; Styrkarsdottir, Unnur; Ntzani, Evangelia E.; Bos, Steffan D.; Esko, Tonu; Evans, Daniel S.; Metrustry, Sarah; Panoutsopoulou, Kalliope; Ramos, Yolande F. M.; Thorleifsson, Gudmar; Tsilidis, Konstantinos K.; Arden, Nigel; Aslam, Nadim; Bellamy, Nicholas; Birrell, Fraser; Blanco García, Francisco J; Carr, Andrew; Chapman, Kay; Day-Williams, Aaaron G.; Deloukas, Panos; Doherty, Michael; Engström, Gunnar; Helgadottir, Hafdis T.; Hofman, Albert; Ingvarsson, Thorvaldur; Jonsson, Helgi; Keis, Aime; Keurentjes, J. Christiaan; Kloppenburg, Margreet; Lind, Penelope A.; McCaskie, Andrew; Martin, Nicholas G.; Milani, Lili; Montgomery, Grant W.; Nelissen, Rob G.H.H.; Nevitt, Michael C.; Nilsson, Peter M.; Ollier, William E.R.; Parimi, Neeta; Rai, Ashok; Ralston, Stuart H.; Reed, Mike R.; Riancho, José A.; Rivadeneira, Fernando; Rodríguez-Fontenla, Cristina; Southam, Lorraine; Thorsteindottir, Unnur; Tsezou, Aspasia; Wallis, Gillian A.; Wilkinson, J. Mark; González, Antonio; Lane, Nancy E.; Lohmander, L. Stefan; Loughlin, John; Metspalu, Andres; Uitterlinden, André G.; Jonsdottir, Ingileif; Stefansson, Kari; Slagboom, P. Eline; Zeggini, Eleftheria; Meulebelt, Ingrid; Ionnidis, John P.A.; Spector, Tim D.; van Meurs, Joyce B.J.; Valdes, Ana M. (BMJ, 2013-08-29)
      [Abstract] OBJECTIVES: Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies ...

    • A model for prediction of in-hospital mortality in patients with subarachnoid hemorrhage 

      Mourelo-Fariña, Mónica; Pértega-Díaz, Sonia; Galeiras, Rita (Springer, 2020-07-15)
      [Abstract] Background: Despite being a rare cause of stroke, spontaneous subarachnoid hemorrhage (SAH) is associated with high mortality rates. The prediction models that are currently being used on SAH patients are ...

    • A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment 

      Gallego-Fábrega, Cristina; Temprano-Sagrera, Gerard; Cárcel-Márquez, Jara; Muiño, Elena; Cullel, Natalia; Lledós, Miquel; Llucià-Carol, Laia; Martín-Campos, Jesús M.; Sobrino, Tomás; Castillo, José; Millán, Mónica; Muñoz-Narbona, Lucía; López-Cancio Martínez, Elena; Ribó, Marc; Álvarez-Sabín, José; Jiménez-Conde, Jordi; Roquer, Jaume; Tur, Silvia; Obach, Victor; Arenillas, Juan; Segura, Tomás; Serrano-Heras, Gemma; Martí-Fàbregas, Joan; Freijo Guerrero, María del Mar; Moniche Álvarez, Francisco; Castellanos, María del Mar; Morrison, Alana C.; Smith, Nicholas L.; de Vries, Paul S.; Fernández-Cadenas, Israel; Sabater-Lleal, María (Elsevier, 2023-12-15)
      [Abstract] Background: Thrombolytic recombinant tissue plasminogen activator (r-tPA) treatment is the only pharmacologic intervention available in the ischemic stroke acute phase. This treatment is associated with an ...

    • A new scenario in metastatic renal cell carcinoma: a SOG‑GU consensus 

      Vázquez Estévez, Sergio; Anido Herranz, Urbano; Lázaro Quintela, Martín; Fernández Calvo, Ovidio; Fernández-Núñez, Natalia; Dios Álvarez, N. de; Varela, V.; Campos Balea, B.; Agraso, S.; Areses, M. C.; Iglesias, L.; Blanco, Moisés; Maciá, S.; Antón-Aparicio, Luis M. (Springer, 2020-02-15)
      [Abstract] Background This article describes and compares approved targeted therapies and the newer immunotherapy agents. Materials and methods This article especially performs an in-depth review of currently available ...

    • A non-secreting pituitary adenoma that changed to a prolactinoma 

      Santiago-Vázquez, Cristina; Palacios-Paino, Nuria; Cordido, Fernando (MDPI, 2024-07-04)
      [Abstract] Pituitary adenomas (PAs) are the third most common brain tumors in adults right after meningiomas and gliomas. Taking into account their hormonal activity in vivo, they can be divided in functioning PAs, which ...

    • A novel procedure for protein extraction from formalin-fixed paraffin-embedded tissues 

      Rodríguez-Rigueiro, Teresa; Valladares-Ayerbes, Manuel; Haz, Mar; Blanco, Moisés; Aparicio Gallego, Guadalupe; Fernández-Puente, Patricia; Blanco García, Francisco J; Lorenzo-Patiño, María J.; Antón-Aparicio, Luis M.; Figueroa, Angélica (Wiley, 2011-05-18)
      [Abstract] Most of the archived pathological specimens in hospitals are kept as formalin-fixed paraffin-embedded tissues (FFPE) for long-term preservation. Up to now, these samples are only used for immunohistochemistry ...

    • A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine 

      Calamia, Valentina; Mateos, Jesús; Fernández-Puente, Patricia; Lourido Salas, Lucía María; Rocha Loureda, Beatriz; Fernández-Costa, Carolina; Montell, Eulalia; Vergés, Josep; Ruiz-Romero, Cristina; Blanco García, Francisco J (Nature, 2014-06-10)
      [Abstract] Osteoarthritis (OA) is the most common age-related rheumatic disease. Chondrocytes play a primary role in mediating cartilage destruction and extracellular matrix (ECM) breakdown, which are main features of the ...

    • A Pilot Randomized Controlled Trial of Aquatic-Based Activities in a Group Occupational Therapy Program for Adults Living With Serious Mental Illness in Spain 

      Seoane Bouzas, María de las Mercedes; De-Rosende, Iván; Meijide-Faílde, Rosa (Wiley, 2021-08-17)
      [Abstract] Although aquatic-based interventions are increasingly used in the psychiatric rehabilitation services, the effects of this type of community program as an adjuvant therapy for psychosocial problems of people ...

    • A predictive clinical-genetic model of tissue plasminogen activator response in acute ischemic stroke 

      Del Río-Espínola, Alberto; Fernández-Cadenas, Israel; Giralt, Dolors; Quiroga, Adoración; Gutiérrez-Agulló, María; Quintana, Manuel; Fernández-Álvarez, Patricia; Domingues-Montanari, Sophie; Mendióroz, Maite; Delgado, Pilar; Turck, Natacha; Ruiz Laza, Agustín; Ribó, Marc; Castellanos, María del Mar; Obach, Victor; Martínez, Sergi; Freijo Guerrero, María del Mar; Jiménez-Conde, Jordi; Cuadrado-Godia, Elisa; Roquer, Jaume; Chacón, Pilar; Martí-Fábregas, Joan; Sánchez, Jean Charles; Montaner, Joan (John Wiley & Sons, 2012-06-09)
      [Abstract] Objective: Wide interindividual variability exists in response to tissue plasminogen activator (t-PA) treatment in the acute phase of ischemic stroke. We aimed to find genetic variations associated with hemorrhagic ...

    • A primary signet ring cell carcinoma of the prostate with bone metastasis with impressive response to FOLFOX and Cetuximab 

      Roldán, Ana Milena; Fernández-Núñez, Natalia; Grande Pulido, Enrique; Álvarez-García, Augusto; Antón-Aparicio, Luis M. (Elsevier, 2012-03-10)

    • A randomized clinical trial to determine the effect of angiotensin inhibitors reduction on creatinine clearance and haemoglobin in heart failure patients with chronic kidney disease and anaemia 

      Pita-Fernández, Salvador; Chouciño Fernández, Teresa; Juega-Puig, J.; Seoane-Pillado, Teresa; López-Calviño, Beatriz; Pértega-Díaz, Sonia; Pedreira, José D.; Gil-Guillén, V. (Wiley, 2014-07-16)
      [Abstract] Background. Chronic kidney disease is a common comorbidity in elderly patients with heart failure. Evidence supports the use of angiotensin inhibitors for patients with heart failure. However, there is little ...