Browsing Investigación (FCS) by Title

Now showing items 1041-1060 of 1289

    • Sacubitril-valsartan, clinical benefits and related mechanisms of action in heart failure with reduced ejection fraction: a review 

      Pascual-Figal, Domingo; Bayés-Genis, Antonio; Beltrán-Troncoso, Paola; Caravaca-Pérez, Pedro; Conde-Martel, Alicia; Crespo-Leiro, María Generosa; Delgado-Jiménez, Juan F.; Díez, Javier; Formiga, Francesc; Manito, Nicolás (Frontiers, 2021-11-11)
      [Abstract] Heart failure (HF) is a clinical syndrome characterized by the presence of dyspnea or limited exertion due to impaired cardiac ventricular filling and/or blood ejection. Because of its high prevalence, it is a ...

    • Sacubitril/valsartan eligibility and outcomes in the ESC-EORP-HFA Heart Failure Long-Term Registry: bridging between European Medicines Agency/Food and Drug Administration label, the PARADIGM-HF trial, ESC guidelines, and real world 

      Kapelios, Chris J.; Lainscak, Mitja; Savarese, Gianluigi; Laroche, Cécile; Seferovic, Petar; Ruschitzka, Frank; Coats, Andrew; Anker, Stefan; Crespo-Leiro, María Generosa; Filippatos, Gerasimos; Piepoli, Massimo; Rosano, Giuseppe; Zanolla, Luisa; Aguiar, Carlos; Murin, Jan; Leszek, Przemyslaw; McDonagh, Theresa; Maggioni, Aldo P.; Lund, Lars H. (Wiley, 2019-05-27)
      [Abstract] Aims: To assess the proportion of patients with heart failure and reduced ejection fraction (HFrEF) who are eligible for sacubitril/valsartan (LCZ696) based on the European Medicines Agency/Food and Drug ...

    • Safety and efficacy of ApTOLL in patients with ischemic stroke undergoing endovascular treatment: a phase 1/2 randomized clinical trial 

      Hernández-Jiménez, Macarena; Abad-Santos, Francisco; Cotgreave, Ian; Gallego, Jaime; Jilma, Bernd; Flores, Alan; Jovin, Tudor G.; Vivancos, José; Hernández-Pérez, María; Molina, Carlos A.; Montaner, Joan; Casariego, Joaquín; Dalsgaard, Mads; Liebeskind, David S.; Cobo, Erik; Castellanos, María del Mar; Cardona Portela, Pere; Masjuán, Jaime; Moniche, Francisco; Tembl, José Ignacio; Terceño Izaga, Mikel; Arenillas, Juan; Calleja, Patricia; Olivot, Jean Marc; Calviere, Lionel; Henon, Hilde; Mazighi, Mikael; Piñeiro, David; Pugliese, Marco; González, Víctor M.; Moro, María Ángeles; García-Tornel, Álvaro; Lizasoain, Ignacio; Ribo, Marc (American Medical Association, 2023-06-20)
      [Abstract] Importance: ApTOLL is a TLR4 antagonist with proven preclinical neuroprotective effect and a safe profile in healthy volunteers. Objective: To assess the safety and efficacy of ApTOLL in combination with ...

    • Safety and Efficacy of Sofosbuvir plus Simeprevir in a Spanish Cohort of 622 Cirrhotic Patients Infected with Genotypes 1 or 4 

      Mariño, Zoe; Pascasio-Acevedo, Juan M.; Sánchez-Antolín, Gloria; Baliellas, C.; Prieto, M.; Moreno, J.M.; Carrión, J.A.; Fernández, I.; Gómez, A.; Montero, J.L.; Castro-Iglesias, Ángeles; Pascual, Sonia; Cabezas, Joaquín; Arencibia, Ana C.; Calleja, J.L.; Sánchez Ruano, Juan José; Castells, Lluis; Albillos, A.; Romero-Gómez, Manuel; García-Samaniego, J.; Narváez, Isidro; Serrano, T.; Giráldez, Álvaro; Xiol, X.; Hontagas, V.; Cuervas-Mons Martínez, Valentín; Crespo, J.; Forns, Xavier (Elsevier, 2016)

    • Safety and efficacy of tirofiban in acute ischemic stroke due to tandem lesions undergoing mechanical thrombectomy: A multicenter randomized clinical trial (ATILA) protocol 

      Medina Rodríguez, Manuel; Moniche, Francisco; Albóniga-Chindurza, Asier de; Ortega-Quintanilla, Joaquín; Ainz-Gómez, Leire; Pardo-Galiana, Blanca; Cabezas-Rodríguez, Juan Antonio; Aguilar-Pérez, Marta; Zamora, Aynara; Delgado-Acosta, Fernando; Jiménez-Gómez, Elvira; Bravo Rey, Isabel; Oteros Fernández, Rafael; Freijo Guerrero, María del Mar; González Díaz, Eva; Escudero-Martínez, Irene; Morale Caba, Lluis; Vielba-Gómez, Isabel; Mosteiro, Sonia; Castellanos, María del Mar; Amaya Pascasio, Laura; Hidalgo, Carlos; Fernández Prudencio, Luis; Ramírez Moreno, José María; Díaz Pérez, José; Sanz-Fernández, Gema; Baena-Palomino, Pablo; Gamero-García, Miguel Ángel; Jiménez Jorge, Silvia; Rosso Fernández, Clara; Montaner, Joan; González García, Alejandro; Zapata-Arriaza, Elena (Sage, 2022-12-28)
      [Abstract] Background: In-stent thrombosis after mechanical thrombectomy (MT) worsen outcomes in acute ischemic stroke (AIS) due to tandem lesions (TL). Although an optimal antiplatelet therapy is needed, the best approach ...

    • Safety and Immunogenicity of SARS-CoV-2 vaccines in people with HIV 

      González de Aledo, Manuel; Cañizares, Angelina; Vázquez-Rodríguez, Pilar; Castro-Iglesias, Ángeles; Moldes, Luz; López, Soledad; Miguez, Enrique; Bou, Germán; Mena, Álvaro (Wolters Kluwer, 2022)
      [Abstract] Objective: To evaluate the safety and the serological response after two doses of mRNA-based SARS-CoV-2 vaccination in people with HIV (PWH). Methods: Participants were evaluated 4 weeks after the second ...

    • Safety and quality of life in women with immediate reconstruction with polyurethane implants after neoadjuvant chemotherapy: outcomes from the Preq-20 trial 

      Acea, Benigno; García Novoa, Alejandra; Cereijo-Garea, Carmen; Conde Iglesias, Carmen; Bouzón Alejandro, Alberto; Díaz Carballada, Carlota (MDPI, 2023-02-09)
      [Abstract] Introduction: Various studies have evaluated the impact of neoadjuvant chemotherapy (NAC) on the complications of breast cancer surgery, most of which were retrospective and did not assess the variables ...

    • Satisfaction Of Spanish Primary School Teachers Regarding Anti-Covid Protocols 

      Sanmiguel Rodríguez, Alberto; Leirós-Rodríguez, Raquel; García-Soidán, J.L; Arufe-Giráldez, Víctor (Gokmen Arslan, 2023)
      [Abstract]: After the closure of the Spanish Primary Education Centres in March 2020, academic and educational institutions began the 2020-2021 academic year with the obligation to abide by the anti-Coronavirus protocols. ...

    • Scaffold-Mediated Gene Delivery for Osteochondral Repair 

      Madry, Henning; Venkatesan, Jagadeesh Kumar; Carballo-Pedrares, Natalia; Rey-Rico, Ana; Cucchiarini, Magali (MDPI, 2020-09-29)
      [Abstract] Osteochondral defects involve both the articular cartilage and the underlying subchondral bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery of gene vectors has ...

    • Searching for Hif1-α interacting proteins in renal cell carcinoma 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Santamarina, Isabel; Valladares-Ayerbes, Manuel; Antón-Aparicio, Luis M. (Springer para Federation of Spanish Oncology Sociesties (FESEO), 2012-08-28)
      [Abstract] Introduction. Kidney tumours are frequently characterised by hypoxic conditions due to a local imbalance between oxygen (O2) supply and consumption. Hif1-α regulates angiogenesis, tumour growth, tumour progression, ...

    • Sedoanalgesia para procedimientos de desbridamiento enzimático en pacientes con quemaduras en cara y cuello 

      Galeiras, Rita; Esmorís, Inés; Mourelo-Fariña, Mónica; Pértega-Díaz, Sonia; López-Suso, Eugenia (Scielo, 2018-07)
      [Resumen] Introducción y Objetivo. La cantidad de procedimientos mínimamente invasivos realizados fuera del quirófano ha crecido en las últimas décadas. La sedación, la analgesia o ambas, pueden ser nece- sarias para muchos ...

    • Sellar and perisellar meningiomas: effects on pituitary function in a spanish cohort observational study 

      Guerrero-Pérez, Fernando; Biagetti, Betina; Paja-Fano, Miguel; Menéndez-Torre, Edelmiro Luis; Rivero, Gonzalo; Dios, Elena; Hanzu, Felicia Alexandra; Martín Rojas-Marcos, Patricia; Irigaray Echarri, Ana; Moure Rodríguez, María Dolores; García-Centeno, Rogelio; González-Fernández, Laura; Enseñat, Joaquim; Mora, Mireia; Villar-Taibo, Rocío; Ortiz García, Isabel M.; Araújo-Castro, Marta; Gándara, Carmen; Ollero García-Agulló, María Dolores; Tenorio-Jiménez, Carmen; Novo-Rodríguez, Cristina; Civantos, Soralla; Simó-Servat, Andreu; Aulinas, Anna; Asla, Queralt; Cordido, Fernando; Novoa-Testa, Iria; Xifra, Gemma; Ayala-Conte, María; Zamarrón, Álvaro; García Berrocal, María Isabel; Iglesias, Pedro (Springer Nature, 2024-12-28)
      [Abstract] Purpose: Studies focused on the effects of sellar and/or perisellar (S/PS) meningiomas on pituitary function are scarce. The primary objective of the present study was to determinate the effects that S/PS ...

    • Semi-intensive monitoring in acute stroke and long-term outcome 

      Silva, Yolanda; Puigdemont, Montserrat; Castellanos, María del Mar; Serena, Joaquín; Suñer, Rosa M.; García, María M.; Dávalos, Antoni (Karger, 2005-01-14)
      [Abstract] Background and purpose: Factors that determine the benefit of stroke units (SU) are unknown. The aim of our study was to analyze whether semi-intensive monitoring during the acute phase of stroke reduces mortality ...

    • Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype 

      Del Rey, Manuel J.; Valín, Álvaro; Usategui, Alicia; Ergueta, Sandra; Martín, Eduardo; Municio, Cristina; Cañete, Juan D.; Blanco García, Francisco J; Criado, Gabriel; Pablos, José L. (BMC, 2019-11-05)
      [Abstract] Background Accumulation of senescent cells has been associated with pro-inflammatory effects with deleterious consequences in different human diseases. The purpose of this study was to analyze cell senescence ...

    • Sensorimotor cortical influences on cuneate nucleus rhythmic activity in the anesthetized cat 

      Mariño Alfonso, Xurxo; Canedo Lamas, Antonio; Aguilar Fernández, Jaime (Elsevier, 1999)
      [Abstract] This work aimed to study whether the sensorimotor cerebral cortex spreads down its rhythmic patterns of activity to the dorsal column nuclei. Extracellular and intracellular recordings were obtained from the ...

    • Sensory processing patterns in developmental coordination disorder, attention deficit hyperactivity disorder and typical development 

      Delgado-Lobete, Laura; Pértega-Díaz, Sonia; Santos-del-Riego, Sergio; Montes-Montes, Rebeca (Elsevier, 2020-02-19)
      [Abstract] Background. Sensory processing difficulties (SPD) are present in children with Developmental Coordination Disorder (DCD) and Attention Deficit and Hyperactivity Disorder (ADHD). However, little is known about ...

    • Ser mujer y reducción de jornada en Galicia: aportes del análisis del discurso crítico desde una mirada ocupacional 

      Ferreira-Marante, Rocío; Veiga-Seijo, Silvia (Ludomedia, 2021-07-08)
      [Resumen] Introducción: En España, la reducción de jornada es un derecho individual de las personas trabajadoras. Los motivos para solicitar dicha reducción están asociados a los cuidados, los cuales son asumidos y asignados ...

    • SERCA2a protein levels are unaltered in human heart failure 

      Ragone, Isabella; Barallobre-Barreiro, Javier; Takov, Kaloyan; Theofilatos, Konstantinos; Yin, Xiaoke; Schmidt, Lukas Emanuel; Doménech, Nieves; Crespo-Leiro, María Generosa; van der Voorn, Stephanie M.; Vink, Aryan; van Veen, Toon A.B.; Bödör, Csaba; Merkely, Béla; Radovits, Tamás; Mayr, Manuel (American Heart Association (AHA), 2023-08-14)

    • Seroprevalence of HCV and HIV infections by year of birth in Spain: impact of US CDC and USPSTF recommendations for HCV and HIV testing 

      Mena, Álvaro; Moldes, Luz; Meijide, Héctor; Cañizares, Angelina; Castro-Iglesias, Ángeles; Delgado, Manuel; Pértega-Díaz, Sonia; Pedreira, José D.; Bou, Germán; Poveda, Eva (PLoS ONE, 2014-12-01)

    • Serum cellular fibronectin and matrix metalloproteinase-9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke: a multicenter confirmatory study 

      Castellanos, María del Mar; Sobrino, Tomás; Millán, Mónica; García, María M.; Arenillas, Juan; Nombela, Florentino; Brea, David; Pérez de la Ossa, Natalia; Serena, Joaquín; Vivancos, José; Castillo, José; Dávalos, Antoni (American Heart Association, 2007-05-03)
      [Abstract] Background and purpose: Plasma levels of cellular fibronectin (c-Fn) > or =3.6 microg/mL and of matrix metalloproteinase-9 (MMP-9) > or =140 ng/mL have been associated with parenchymal hematoma (PH) after ...