Now showing items 93-112 of 159

    • Levosimendan Efficacy and Safety: 20 Years of SIMDAX in Clinical Use 

      Papp, Zoltán; Álvarez, Julián; Bettex, Dominique; Bouchez, Stefan; Brito, Dulce; Černý, Vladimir; Comin-Colet; Comin-Colet, Josep; Crespo-Leiro, María Generosa; Delgado-Jiménez, Juan F.; Édes, István; Eremenko, Alexander; Farmakis, Dimitrios; Fedele, Francesco; Fonseca, Candida; Fruhwald, Sonja; Girardis, Massimo; Guarracino, Fabio; Harjola, Veli-Pekka; Heringlake, Matthias; Herpain, Antoine; Heunks, Leo; Husebye, Tryggve; Ivancan, Višnja; Karason, Kristjan; Kaul, Sundeep; Kivikko, Matti; Kubica, Janek; Masip, Josep; Matskeplishvili, Simon; Mebazaa, Alexandre; Nieminen, Markku S.; Oliva, Fabrizio; Papp, Julius G.; Parissis, John; Parkhomenko, Alexander; Põder, Pentti; Pölzl, Gerhard; Reinecke, Alexander; Ricksten, Sven-Erik; Riha, Hynek; Rudiger, Alain; Sarapohja, Toni; Schwinger, Robert H. G.; Toller, Wolfgang; Tritapepe, Luigi; Tschöpe, Carsten; Wikström, Gerhard; Lewinski, Dirk von; Vrtovec, Bojan; Pollesello, Piero; Agostoni, Piergiuseppe (Wolters Kluwer, 2020-07)
      [Abstract] Levosimendan was first approved for clinical use in 2000, when authorization was granted by Swedish regulatory authorities for the hemodynamic stabilization of patients with acutely decompensated chronic heart ...
    • Light Chain and Transthyretin Cardiac Amyloidosis: Clinical Characteristics, Natural History and Prognostic Factors 

      Barge-Caballero, Gonzalo; Vázquez-García, Raquel; Barge-Caballero, Eduardo; Couto-Mallón, David; Paniagua-Martín, María J.; Barriales-Villa, Roberto; Piñón-Esteban, Pablo; Bouzas-Mosquera, Alberto; Pombo-Otero, Jorge; Debén-Ariznavarreta, Guillermo; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Elsevier, 2021-03-13)
      [Abstract] Introduction and objectives. Light-chain amyloidosis (AL-CA) and transthyretin amyloidosis (ATTR-CA) are the most common types of cardiac amyloidosis (CA). We sought to study the clinical characteristics and ...
    • Malignancy following heart transplantation: differences in incidence and prognosis between sexes – a multicenter cohort study 

      Minguito‐Carazo, Carlos; Gómez-Bueno, Manuel; Almenar‐Bonet, Luis; Barge-Caballero, Eduardo; González-Vílchez, Francisco; Delgado-Jiménez, Juan F.; Arizón-del-Prado, José M.; Sousa-Casasnovas, Iago; Mirabet, Sonia; González-Costello, José; Sobrino-Márquez, José Manuel; Pérez-Villa, Félix; Díaz Molina, Beatriz; Rábago, Gregorio; Blasco-Peiró, Teresa; De la Fuente-Galán, Luis; Garrido-Bravo, Iris P.; García-Guereta, Luis; Camino, Manuela; Albert-Brotons, Dimpna C.; Muñiz, Javier; Crespo-Leiro, María Generosa (Wiley Online Library, 2021-03-12)
      [Abstract] Male patients are at increased risk for developing malignancy postheart transplantation (HT); however, real incidence and prognosis in both genders remain unknown. The aim of this study was to assess differences ...
    • Many heart transplant biopsies currently diagnosed as no rejection have mild molecular antibody-mediated rejection-related changes 

      Halloran, Philip F.; Madill-Thomsen, Katelynn; Aliabadi-Zuckermann, Arezu Z.; Cadeiras, Martín; Crespo-Leiro, María Generosa; Depasquale, Eugene C.; Deng, Mario; Gökler, Johannes; Kim, Daniel H.; Kobashigawa, Jon; Macdonald, Peter; Potena, Luciano; Shah, Keyur; Stehlik, Josef; Zuckermann, Andreas (Elsevier, 2021-08-04)
      [Abstract] Background: The Molecular Microscope (MMDx) system classifies heart transplant endomyocardial biopsies as No-rejection (NR), Early-injury, T cell-mediated (TCMR), antibody-mediated (ABMR), mixed, and possible ...
    • Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population 

      Fernández Caggiano, Mariana; Barallobre-Barreiro, Javier; Rego-Pérez, Ignacio; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Grille Cancela, Zulaika; Blanco García, Francisco J; Doménech, Nieves (Elsevier, 2013-03-23)
      [Abstract] Idiopathic dilated cardiomyopathy (IDC) is a structural heart disease with strong genetic background. The different single nucleotide polymorphisms (SNPs) that constitute mitochondrial haplogroups could play an ...
    • Mitochondrial Pyruvate Carrier Abundance Mediates Pathological Cardiac Hypertrophy 

      Fernández-Caggiano, Mariana; Kamynina, Alisa; Francois, Asvi A.; Prysyazhna, Oleksandra; Eykyn, Thomas R.; Krasemann, Susanne; Crespo-Leiro, María Generosa; García-Vieites, M.; Bianchi, Katiuscia; Morales, Valle; Doménech, Nieves; Eaton, Philip (Springer Nature, 2020-10-26)
      [Abstract] Cardiomyocytes rely on metabolic substrates, not only to fuel cardiac output, but also for growth and remodelling during stress. Here we show that mitochondrial pyruvate carrier (MPC) abundance mediates ...
    • Multi-omics approach reveals prebiotic and potential antioxidant effects of essential oils from the mediterranean diet on cardiometabolic disorder using humanized gnotobiotic mice 

      Sánchez-Quintero, María José; Delgado, Josué; Martín Chaves, Laura; Medina-Vera, Dina; Murri, Mora; Becerra-Muñoz, Víctor M.; Estévez, Mario; Crespo-Leiro, María Generosa; Paz López, Guillermo; González-Jiménez, Andrés; García Ranea, Juan A.; Queipo-Ortuño, María Isabel; Plaza-Andrades, Isaac; Rodríguez-Capitán, Jorge; Pavón-Morón, Francisco Javier; Jiménez-Navarro, Manuel (MDPI, 2023-08-20)
      [Abstract] Essential oils sourced from herbs commonly used in the Mediterranean diet have demonstrated advantageous attributes as nutraceuticals and prebiotics within a model of severe cardiometabolic disorder. The primary ...
    • Omecamtiv mecarbil for patients with severe systolic dysfunction and hypotension 

      Crespo-Leiro, María Generosa; McDonagh, Theresa A.; Barge-Caballero, Eduardo (Oxford Academic, 2022-12-21)
    • Omecamtiv Mecarbil in Chronic Heart Failure With Reduced Ejection Fraction: GALACTIC‐HF Baseline Characteristics and Comparison With Contemporary Clinical Trials 

      Teerlink, John R.; Díaz, Rafael; Felker, G. Michael; McMurray, John J.V.; Metra, Marco; Solomon, Scott D.; Adams, Kirkwood F.; Anand, Inder; Arias‐Mendoza, Alexandra; Biering‐Sørensen, Tor; Böhm, Michael; Bonderman, Diana; Cleland, John G.F.; Corbalán, Ramón; Crespo-Leiro, María Generosa; Dahlström, Ulf; Echeverría Correa, Luis E.; Fang, James C.; Filippatos, Gerasimos; Fonseca, Cándida; Goncalvesova, Eva; Goudev, Assen R.; Howlett, Jonathan G.; Lanfear, David E.; Lund, Mayanna; Macdonald, Peter; Mareev, Vyacheslav; Momomura, Shin‐ichi; O'Meara, Eileen; Parkhomenko, Alexander; Ponikowski, Piotr; Ramires, Felix J.A.; Serpytis, Pranas; Sliwa, Karen; Spinar, Jindrich; Suter, Thomas M.; Tomcsanyi, Janos; Vandekerckhove, Hans; Vinereanu, Dragos; Voors, Adriaan A.; Yilmaz, Mehmet B.; Zannad, Faiez; Sharpsten, Lucie; Legg, Jason C.; Abbasi, Siddique A.; Varin, Claire; Malik, Fady I.; Kurtz, Christopher E. (Willey Online Library, 2020-09-20)
      [Abstract] Aims The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is being tested in the Global Approach ...
    • Oxygen therapy and palliative care in patients with heart failure. Response 

      García-Pinilla, José Manuel; Díez-Villanueva, Pablo; Crespo-Leiro, María Generosa; Bonanad-Lozano, Clara (Elsevier, 2020-05-04)
    • Paroxysmal bradyarrhythmias are frequent among heart transplant recipients with unexplained syncope: a study based on implantable loop recorders 

      Martínez-Paz, E.; Barge-Caballero, Eduardo; Álvarez-Roy, Laura; Barge-Caballero, Gonzalo; Couto-Mallón, David; Paniagua-Martín, María J.; Mosquera-Pérez, Ignacio; Pérez-Álvarez, Luisa; Muñiz, Javier; Cuenca-Castillo, José J.; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Wiley, 2017-12-13)
    • Participation in a clinical trial is associated with lower mortality but not lower risk of HF hospitalization in patients with heart failure: observations from the ESC EORP Heart Failure Long-Term Registry 

      Kapelios, Chris J.; Benson, Lina; Crespo-Leiro, María Generosa; Anker, Stefan; Coats, Andrew J.S.; Chioncel, Ovidiu; Filippatos, Gerasimos; Lainscak, Mitja; McDonagh, Theresa; Mebazaa, Alexandre; Metra, Marco; Piepoli, Massimo F.; Rosano, Giuseppe M.C.; Ruschitzka, Frank; Savarese, Gianluigi; Seferovic, Petar M.; Volterrani, Maurizio; Maggioni, Aldo P.; Lund, Lars H. (2023-03-04)
    • Perfiles analíticos pre-configurados en insuficiencia cardiaca: implementación y uso en el Sistema Nacional de Salud Español 

      Almenar-Bonet, Luis; Blasco-Peiró, Teresa; Laiz Marro, Begoña; Camafort-Babkowski, Miguel; Buño Soto, Antonio; Crespo-Leiro, María Generosa (De Gruyter, 2022-03-07)
      [Resumen] Objetivos. El uso de los perfiles analíticos pre-configurados (PAPs) en el contexto de la insuficiencia cardíaca (IC) podría ayudar a realizar un mejor manejo clínico y gestión eficiente del paciente. Los objetivos ...
    • Performance of gene-expression profiling test score variability to predict future clinical events in heart transplant recipients 

      Crespo-Leiro, María Generosa; Stypmann, Jörg; Schulz, Uwe; Zuckermann, Andreas; Mohacsi, Paul; Bara, Christoph; Ross, Heather; Parameshwar, Jayan; Zakliczynski, Michal; Fiocchi, Roberto; Hoefer, Daniel; Deng, Mario; Leprince, Pascal; Hiller, David; Eubank, Emir; Yee, James P.; Vanhaecke, Johan (BioMed Central, 2015-10-09)
      [Abstract] Background. A single non-invasive gene expression profiling (GEP) test (AlloMap®) is often used to discriminate if a heart transplant recipient is at a low risk of acute cellular rejection at time of testing. ...
    • Performance of prognostic risk scores in chronic heart failure patients enrolled in the European Society of Cardiology Heart Failure long-term registry 

      Canepa, Marco; Fonseca, Candida; Chioncel, Ovidiu; Laroche, Cécile; Crespo-Leiro, María Generosa; Coats, Andrew J.S.; Mebazaa, Alexandre (Elsevier, 2018-06)
      [Abstract] Objectives. This study compared the performance of major heart failure (HF) risk models in predicting mortality and examined their utilization using data from a contemporary multinational registry. Background. ...
    • Persistent Pulmonary Hypertension in Corrected Valvular Heart Disease: Hemodynamic Insights and Long‐Term Survival 

      Bermejo, Javier; González‐Mansilla, Ana; Mombiela, Teresa; Fernández, Ana I.; Martínez‐Legazpi, Pablo; Yotti, Raquel; García‐Orta, Rocío; Sánchez‐Fernández, Pedro L.; Castaño, Mario; Segovia-Cubero, Javier; Escribano‐Subias, Pilar; San Román, J. Alberto; Borrás, Xavier; Alonso‐Gómez, Angel; Botas, Javier; Crespo-Leiro, María Generosa; Velasco, Sonia; Bayes-Genis, Antoni; López, Amador; Muñoz‐Aguilera, Roberto; Jiménez‐Navarro, Manuel; González‐Juanatey, J.R.; Evangelista, Arturo; Elízaga, Jaime; Martín‐Moreiras, Javier; González‐Santos, José M.; Moreno‐Escobar, Eduardo; Fernández‐Avilés, Francisco (Willey, 2021-01-19)
      [Abstract] Background. The determinants and consequences of pulmonary hypertension after successfully corrected valvular heart disease remain poorly understood. We aim to clarify the hemodynamic bases and risk factors for ...
    • Polymorphisms in genes related to the complement system and antibody-mediated cardiac allograft rejection 

      Marrón Liñares, Grecia Manuela; Núñez, Lucía; Crespo-Leiro, María Generosa; Barge-Caballero, Eduardo; Pombo-Otero, Jorge; Paniagua-Martín, María J.; Suárez-Fuentetaja, Natalia; Cid, Javier; Grille Cancela, Zulaika; Muñiz, Javier; Tan, Carmela D.; Rene Rodríguez, E.; Vázquez Rodríguez, José Manuel; Hermida-Prieto, Manuel (Elsevier, 2017-07-15)
      [Abstract] Background. Heart transplantation (HT) is a life-saving treatment for patients with end-stage heart failure. One of the main problems after HT is the humoral response termed antibody-mediated rejection (AMR). ...
    • Popeye's sign, heart disease, and amyloidosis 

      Barge-Caballero, Gonzalo; Gargallo-Fernández, Paula; Barge-Caballero, Eduardo; Crespo-Leiro, María Generosa (Elsevier, 2019-02-21)
    • POT1 and damage response malfunction trigger acquisition of somatic activating mutations in the VEGF pathway in cardiac angiosarcomas 

      Calvete, Oriol; García-Pavía, Pablo; Domínguez, Fernando; Mosteiro, Lluc; Pérez-Cabornero, Lucía; Cantalapiedra, Diego; Zorio, Esther; Ramón y Cajal, Teresa; Crespo-Leiro, María Generosa; Teulé, Álex; Lázaro, Conxi; Morente, Manuel; Urioste, Miguel; Benitez, Javier (American Heart Association, 2019-09-17)
      [Abstract] Background Mutations in the POT1 gene explain abnormally long telomeres and multiple tumors including cardiac angiosarcomas (CAS). However, the link between long telomeres and tumorigenesis is poorly ...
    • Preoperative toxoplasma gondii serostatus does not affect long-term survival of cardiac transplant recipients: analysis of the Spanish Heart Transplantation Registry 

      Barge-Caballero, Eduardo; Almenar-Bonet, Luis; Crespo-Leiro, María Generosa; Brossa-Loidi, Vicens; Rangel-Sousa, Diego; Gómez-Bueno, Manuel; Farrero-Torres, Marta; Díaz-Molina, Beatriz; Delgado-Jiménez, Juan F.; Martínez-Sellés, Manuel; López-Granados, Amador; De la Fuente-Galán, Luis; González-Costello, José; Garrido-Bravo, Iris P.; Blasco-Peiró, Teresa; Rábago, Gregorio; González-Vílchez, Francisco (Elsevier, 2017-10-07)
      [Abstract] Background. It's unclear whether pre-transplant T. gondii seropositivity is associated with impaired survival in heart transplant recipients. Objectives. To test the above-mentioned hypothesis in the Spanish ...