Now showing items 1-20 of 119

    • 2019 EACTS Expert Consensus on long-term mechanical circulatory support 

      Potapov, Evgenij V.; Antonides, Christiaan; Crespo-Leiro, María Generosa; Combes, Alain; Färber, Gloria; Hannan, Margaret M.; Kukucka, Marian; De Jonge, Nicolaas; Loforte, Antonio; Lund, Lars H.; Mohacsi, Paul; Morshuis, Michiel; Netuka, Ivan; Özbaran, Mustafa; Pappalardo, Federico; Scandroglio, Anna Mara; Schweiger, Martin; Tsui, Steven; Zimpfer, Daniel; Gustafsson, Fin (Oxford, 2019-05-17)
      [Abstract] Long-term mechanical circulatory support (LT-MCS) is an important treatment modality for patients with severe heart failure. Different devices are available, and many—sometimes contradictory—observations regarding ...
    • A 3-biomarker 2-point-based risk stratification strategy in acute heart failure 

      Álvarez-García, Jesús; García-Osuna, Álvaro; Vives-Borrás, Miquel; Ferrero-Gregori, Andreu; Martinez-Sellés, Manuel; Vázquez, Rafael; González-Juanatey, J.R.; Rivera, Miguel; Segovia-Cubero, Javier; Pascual-Figal, Domingo A.; Bover-Freire, Ramón; Bascompte, Ramón; Delgado, Juan; Grau Sepúlveda, Andrés; Bardají, Alfredo; Pérez-Villa, Félix; Zamorano, José Luis; Crespo-Leiro, María Generosa; Sánchez, Pedro Luis; Ordoñez-Llanos, Jordi; Cinca Cuscullola, Juan (Frontiers, 2021-10-22)
      [Abstract] Introduction and Objectives: Most multi-biomarker strategies in acute heart failure (HF) have only measured biomarkers in a single-point time. This study aimed to evaluate the prognostic yielding of NT-proBNP, ...
    • A comprehensive characterization of acute heart failure with preserved versus mildly reduced versus reduced ejection fraction - insights from the ESC-HFA EORP Heart Failure Long-Term Registry 

      Kaplon-Cieslicka, Agnieszka; Benson, Lina; Chioncel, Ovidiu; Crespo-Leiro, María Generosa; Coats, Andrew J.S.; Anker, Stefan; Filippatos, Gerasimos; Ruschitzka, Frank; Hage, Camilla; Drozdz, Jaroslaw; Seferovic, Petar; Rosano, Giuseppe M.C.; Piepoli, Massimo; Mebazaa, Alexandre; McDonagh, Theresa; Lainscak, Mitja; Savarese, Gianluigi; Ferrari, Roberto; Maggioni, Aldo P.; Lund, Lars H. (Wiley, 2021-12-27)
      [Abstract] Aims: To perform a comprehensive characterization of acute heart failure (AHF) with preserved (HFpEF), versus mildly reduced (HFmrEF) versus reduced ejection fraction (HFrEF). Methods and results: Of 5951 ...
    • A pragmatic approach to the use of inotropes for the management of acute and advanced heart failure: an expert panel consensus 

      Farmakis, Dimtrios; Agostoni, Piergiuseppe; Baholli, Loant; Bautin, Andrei; Comin-Colet, Josep; Crespo-Leiro, María Generosa; Fedele, Francesco; García-Pinilla, José Manuel; Giannakoulas, George; Grigioni, Francesco; Gruchała, Marcin; Gustafsson, Finn; Harjola, Veli-Pekka; Hasin, Tal; Herpain, Antoine; Iliodromitis, Efstathios K.; Karason, Kristjan; Kivikko, Matti; Liaudet, Lucas; Ljubas-Maček, Jana; Marini, Marco; Masip, Josep; Mebazaa, Alexandre; Nikolaou, Maria; Ostadal, Petr; Põder, Pentti; Pollesello, Piero; Polyzogopoulou, Eftihia; Pölzl, Gerhard; Tschope, Carsten; Varpula, Marjut; Lewinski, Dirk von; Vrtovec, Bojan; Yilmaz, Mehmet Birhan; Zima, Endre; Parissis, John (Elsevier, 2019-12-15)
      [Abstract] Inotropes aim at increasing cardiac output by enhancing cardiac contractility. They constitute the third pharmacological pillar in the treatment of patients with decompensated heart failure, the other two being ...
    • Adherence to the ESC heart failure treatment guidelines in Spain: ESC Heart Failure Long-term Registry 

      Crespo-Leiro, María Generosa; Segovia Cubero, Javier; González-Costello, José; Bayes-Genis, Antoni; López-Fernández, Silvia; Roig, Eulàlia; Sanz-Julve, Marisa; Fernández-Vivancos, Carla; Mora-Martín, Manuel de; García-Pinilla, José Manuel; Varela-Román, Alfonso; Almenar-Bonet, Luis; Lara-Padrón, Antonio; Fuente Galán, Luis de la; Delgado-Jiménez, Juan F. (Elsevier para Sociedad Española de Cardiología, 2015-05-21)
      [Abstract] Introduction and objectives. To estimate the percentage of heart failure patients in Spain that received the European Society of Cardiology recommended treatments, and in those that did not, to determine the ...
    • Advanced heart failure: a position statement of the Heart Failure Association of the European Society of Cardiology 

      Crespo-Leiro, María Generosa; Metra, Marco; Lund, Lars H.; Milicic, Davor; Costanzo, Maria Rosa; Filippatos, Gerasimos; Gustafsson, Finn; Tsui, Steven; Barge-Caballero, Eduardo; De Jonge, Nicolaas; Frigerio, Maria; Hamdan, Righab; Hasin, Tal; Hülsmann, Martin; Nalbantgil, Sanem; Potena, Luciano; Bauersachs, Johann; Gkouziouta, Aggeliki; Ruhparwar, Arjang; Ristic, A.D.; Straburzynska-Migaj, Ewa; McDonagh, Theresa; Seferovic, Petar M.; Ruschitzka, Frank (Wiley, 2018-05-27)
      [Abstract] This article updates the Heart Failure Association of the European Society of Cardiology (ESC) 2007 classification of advanced heart failure and describes new diagnostic and treatment options for these patients. ...
    • Advanced heart failure: definition, epidemiology, and clinical course 

      Crespo-Leiro, María Generosa; Barge-Caballero, Eduardo (Elsevier, 2021-07-15)
      [Abstract] Advanced heart failure (HF) is characterized by a progressive worsening of symptoms disabling for daily life, refractory to all therapies, and with high mortality. These patients may be candidates for life-prolonging ...
    • AGT haplotype in ITGA4 gene is related to antibody-mediated rejection in heart transplant patients 

      Núñez, Lucía; Marrón Liñares, Grecia Manuela; Crespo-Leiro, María Generosa; Barge-Caballero, Eduardo; Álvarez López, Eloy; Suárez-Fuentetaja, Natalia; Paniagua-Martín, María J.; Pombo-Otero, Jorge; Muñiz, Javier; Tan, Carmela D.; Rene Rodríguez, E.; Vázquez Rodríguez, José Manuel (Stanislaw Stepkowski,, 2019-07-23)
      [Abstract] Introduction. One of the main problems involved in heart transplantation (HT) is antibody-mediated rejection (AMR). Many aspects of AMR are still unresolved, including its etiology, diagnosis and treatment. ...
    • An integrated molecular diagnostic report for heart transplant biopsies using an ensemble of diagnostic algorithms 

      Parkes, Michael D.; Aliabadi, Arezu Z.; Cadeiras, Martin; Crespo-Leiro, María Generosa; Deng, Mario; Depasquale, Eugene C.; Goekler, Johannes; Kim, Daniel H.; Kobashigawa, Jon; Loupy, Alexandre; Macdonald, Peter; Potena, Luciano; Zuckermann, Andreas; Halloran, Philip F. (Elsevier, 2019-02-06)
      [Abstract] BACKGROUND. We previously reported a microarray-based diagnostic system for heart transplant endomyocardial biopsies (EMBs), using either 3-archetype (3AA) or 4-archetype (4AA) unsupervised algorithms to estimate ...
    • Analysis of mitochondrial proteins in the surviving myocardium after ischemia identifies mitochondrial pyruvate carrier expression as possible mediator of tissue 

      Fernández Caggiano, Mariana; Prysyazhna, Oleksandra; Barallobre-Barreiro, Javier; Calviño Santos, Ramón; Aldama López, Guillermo; Crespo-Leiro, María Generosa; Eaton, Philip; Doménech, Nieves (American Society for Biochemistry and Molecular Biology, 2016-01-01)
    • Anemia at hospital admission and its relation to outcomes in patients with heart failure (from the polish cohort of 2 European Society of Cardiology Heart Failure Registries) 

      Tyminska, Agata; Kaplon-Cieslicka, Agnieszka; Ozieranski, Krzysztof; Peller, Michal; Balsam, Pawel; Marchel, Michal; Crespo-Leiro, María Generosa; Maggioni, Aldo P.; Jankowska, Ewa A.; Drozdz, Jaroslaw; Filipiak, Krzysztof J.; Opolski, Grzegorz (Elsevier, 2017)
      [Abstract] Anemia is a commonly observed co-morbidity in heart failure (HF). The aim of the study was to assess prevalence, risk factors for, and effect of anemia on short- and long-term outcomes in HF. The study included ...
    • Association between diabetes and 1-year adverse clinical outcomes in a multinational cohort of ambulatory patients with chronic heart failure: results from the ESC-HFA Heart Failure Long-Term Registry 

      Dauriz, Marco; Targher, Giovanni; Laroche, Cécile; Temporelli, Pier Luigi; Ferrari, Roberto; Anker, Stefan; Coats, Andrew; Filippatos, Gerasimos; Crespo-Leiro, María Generosa; Mebazaa, Alexandre; Piepoli, Massimo F.; Maggioni, Aldo P.; Tavazzi, Luigi (American Diabetes Association, 2017-03-02)
      [Abstract] OBJECTIVE: Diabetes mellitus is associated with an increased risk of cardiovascular disease (CVD) and death. Because the prevalence of diabetes is rising worldwide and chronic heart failure (CHF) is becoming ...
    • Association between loop diuretic dose changes and outcomes in chronic heart failure: observations from the ESC-EORP Heart Failure Long-Term Registry 

      Kapelios, Chris J.; Laroche, Cécile; Crespo-Leiro, María Generosa; Anker, Stefan; Coats, Andrew J.S.; Díaz-Molina, Beatriz; Filippatos, Gerasimos; Lainscak, Mitja; Maggioni, Aldo P.; McDonagh, Theresa A.; Mebazaa, Alexandre; Metra, Marco; Moura, Brenda; Mullens, Wilfried; Piepoli, Massimo F.; Rosano, Giuseppe; Ruschitzka, Frank; Seferovic, Petar M.; Lund, Lars H. (Willey Online Library, 2020-04-01)
      [Abstract] Aims. Guidelines recommend down-titration of loop diuretics (LD) once euvolaemia is achieved. In outpatients with heart failure (HF), we investigated LD dose changes in daily cardiology practice, agreement ...
    • Atlas of the clinical genetics of human dilated cardiomyopathy 

      Haas, Jan; Frese, Karen S.; Peil, Barbara; Kloos, Wanda; Keller, Andreas; Nietsch, Rouven; Feng, Zhu; Müller, Sabine; Kayvanpour, Elham; Vogel, Britta; Sedaghat-Hamedani, Farbod; Lim, Wie-Keat; Zhao, Xiaohong; Fradkin, Dmitriy; Köhler, Doreen; Fischer, Simon; Franke, Jennifer; Marquart, Sabine; Barb, Ioana; Li, Daniel Tian; Amr, Ali; Ehlermann, Philipp; Mereles, Derliz; Weis, Tanja; Hassel, Sarah; Kremer, Andreas; King, Vanessa; Wirsz, Emil; Isnard, Richard; Komajda, Michel; Serio, Alessandra; Grasso, Maurizia; Syrris, Petros; Wicks, Eleanor; Plagnol, Vincent; Lopes, Luis; Gadgaard, Tenna; Eiskjaer, Hans; Jorgensen, Mads; García-Giustiniani, Diego; Ortiz-Genga, Martín; Crespo-Leiro, María Generosa; Deprez, Rondal H. Lekanne Dit; Christiaans, Imke; Rijsingen, Ingrid A. van; Wilde, Arthur A.; Waldenstrom, Anders; Bolognesi, Martino; Bellazzi, Riccardo; Mörner, Stellan; Lorenzo Bermejo, Justo; Monserrat, Lorenzo; Villard, Eric; Mogensen, Jens; Pinto, Yigal M.; Charron, Philippe; Elliott, Perry; Arbustini, Eloisa; Katus, Hugo A.; Meder, Benjamin (Oxford para European Society of Cardiology, 2014-08-27)
      [Abstract] Aim. Numerous genes are known to cause dilated cardiomyopathy (DCM). However, until now technological limitations have hindered elucidation of the contribution of all clinically relevant disease genes to DCM ...
    • Body surface area as a prognostic marker in chronic heart failure patients: results from the Heart Failure Registry of the Heart Failure Association of the European Society of Cardiology 

      Zafrir, Barak; Salman, Nabeeh; Crespo-Leiro, María Generosa; Anker, Stefan; Coats, Andrew J.; Ferrari, Roberto; Filippatos, Gerasimos; Maggioni, Aldo P.; Mebazaa, Alexandre; Piepoli, Massimo Francesco; Ruschitzka, Frank; Paniagua-Martín, María J.; Segovia-Cubero, Javier; Laroche, Cecile; Amir, Offer (Wiley, 2016-07-18)
      [Abstract] AIMS: The 'obesity paradox' is consistently observed in patients with heart failure (HF). We investigated the relationship of body surface area (BSA) to mortality and hospitalizations in patients with chronic ...
    • Brachial pulse pressure in acute heart failure. Results of the Heart Failure Registry 

      Bonapace, Stefano; Rossi, Andrea; Laroche, Cécile; Crespo-Leiro, María Generosa; Piepoli, Massimo F.; Coats, Andrew J. S.; Dahlström, Ulf; Malek, Filip; Macarie, Cezar; Temporelli, Pier Luigi; Maggioni, Aldo P.; Tavazzi, Luigi (Willey Online Library, 2019-12-09)
      [Abstract] Aims To investigate the still uncertain independent prognostic impact of pulse pressure (PP) in acute heart failure (HF), in particular across the left ventricular ejection fraction (EF) phenotypes, and the ...
    • Building research initiative group: chronic illness management and adherence in transplantation (BRIGHT) study: study protocol 

      Berben, Lut; Denhaerynck, Kris; Dobbels, Fabienne; Engberg, Sandra; Vanhaecke, Johan; Crespo-Leiro, María Generosa; Russell, Cynthia L.; De Geest, Sabina (Wiley, 2014-09-26)
      [Abstract] AIM: This article describes the rationale, design and methodology of the Building research initiative group: chronic illness management and adherence in transplantation (BRIGHT) study. This study of heart ...
    • Calidad de vida relacionada con la salud de los pacientes con insuficiencia cardiaca crónica sistólica en España: resultados del estudio VIDA-IC 

      Comín, Josep; Anguita, Manuel; Formiga, Francesc; Almenar, Luis; Crespo-Leiro, María Generosa; Manzano, Luis; Muñiz, Javier; Chaves, José; Frutos, Trinidad de; Enjuanes, Cristina (Elsevier, 2015-12-23)
      [Resumen] Introducción y objetivos. La calidad de vida relacionada con la salud de los pacientes con insuficiencia cardiaca está afectada. Hay poca información sobre los factores clínicos asociados a esta mala calidad de ...
    • Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure 

      Teerlink, John R.; Díaz, Rafael; Felker, G. Michael; McMurray, John J.V.; Metra, Marco; Solomon, Scott D.; Adams, Kirkwood F.; Anand, Inder; Arias‐Mendoza, Alexandra; Biering‐Sørensen, Tor; Böhm, Michael; Bonderman, Diana; Cleland, John G.F.; Corbalán, Ramón; Crespo-Leiro, María Generosa; Dahlström, Ulf; Echeverría Correa, Luis E.; Fang, James C.; Filippatos, Gerasimos; Fonseca, Cándida; Goncalvesova, Eva; Goudev, Assen R.; Howlett, Jonathan G.; Lanfear, David E.; Li, J.; Lund, Mayanna; Macdonald, Peter; Mareev, Vyacheslav; Momomura, Shin‐ichi; O'Meara, Eileen; Parkhomenko, Alexander; Ponikowski, Piotr; Ramires, Felix J.A.; Serpytis, Pranas; Sliwa, Karen; Spinar, Jindrich; Suter, Thomas M.; Tomcsanyi, Janos; Vandekerckhove, Hans; Vinereanu, Dragos; Voors, Adriaan A.; Yilmaz, Mehmet B.; Zannad, Faiez; Sharpsten, Lucie; Legg, Jason C.; Varin, Claire; Honarpour, N.; Abbasi, Siddique A.; Malik, Fady I.; Kurtz, Christopher E. (Massachusetts Medical Society, 2020-11-13)
      [Abstract] BACKGROUND. The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular ...
    • Cardiac Protection Induced by Urocortin-2 Enables the Regulation of Apoptosis and Fibrosis After Ischemia and Reperfusion Involving miR-29a Modulation 

      Mayoral-González, Isabel; Calderón-Sánchez, Eva M.; Galeano-Otero, Isabel; Martín-Bórnez, Marta; Gutiérrez-Carretero, Encarnación; Fernández-Velasco, María; Domenech, Nieves; Crespo-Leiro, María Generosa; Gómez, Ana María; Ordoñez-Fernández, Antonio; Hmadcha, Abdelkrim; Smani, Tarik (Elsevier, 2022-01-28)
      [Abstract] Urocortin-2 (Ucn-2) has demonstrated cardioprotective actions against myocardial ischemia-reperfusion (I/R) injuries. Herein, we explored the protective role of Ucn-2 through microRNAs (miRNAs) post-transcriptional ...