Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population

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http://hdl.handle.net/2183/19475
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España
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Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish populationAuthor(s)
Date
2013-03-23Citation
Fernández-Caggiano M, Barallobre-Barreiro J, Rego-Pérez I, et al. Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in spanish population. Mitochondrion. 2013;13(4):263-268
Abstract
[Abstract] Idiopathic dilated cardiomyopathy (IDC) is a structural heart disease with strong genetic background. The different single nucleotide polymorphisms (SNPs) that constitute mitochondrial haplogroups could play an important role in IDC progression. The aim of this study was to test frequencies of mitochondrial haplogroups in healthy controls (n = 422) and IDC patients (n = 304) of a Caucasian Spanish population. To achieve this, ten major European haplogroups were identified. Frequencies and Odds Ratios for the association between IDC and haplogroups were calculated in both groups. We found that compared to healthy controls, the prevalence of haplogroup H was significantly higher in IDC patients (40.0% vs 50.7%, p-value = 0.040).
Keywords
Mitochondrial haplogroups
Idiopathic dilated cardiomyopathy
Oxidative stress
Reactive oxygen species
Single nucleotide polymorphisms
Idiopathic dilated cardiomyopathy
Oxidative stress
Reactive oxygen species
Single nucleotide polymorphisms
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Rights
Atribución-NoComercial-SinDerivadas 3.0 España
ISSN
1567-7249
1872-8278
1872-8278