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A novel procedure for protein extraction from formalin-fixed paraffin-embedded tissues
(Wiley, 2011-05-18)
[Abstract] Most of the archived pathological specimens in hospitals are kept as formalin-fixed paraffin-embedded tissues (FFPE) for long-term preservation. Up to now, these samples are only used for immunohistochemistry ...
A single nucleotide polymorphism in the Il17ra promoter is associated with functional severity of ankylosing spondylitis
(PLoS, 2016-07-14)
[Abstract] The aim of this study was to identify new genetic variants associated with the severity of ankylosing spondylitis (AS). We sequenced the exome of eight patients diagnosed with AS, selected on the basis of the ...
Translation of clinical problems in osteoarthritis into pathophysiological research goals
(BMJ, 2016-05-26)
[Abstract] Osteoarthritis (OA) accounts for more disability among the elderly than any other disease and is associated with an increased mortality rate. The prevalence in Europe will rise in the future since this continent ...
OARSI Guidelines for the Non-Surgical Management of Knee, Hip, and Polyarticular Osteoarthritis
(Elsevier, 2019-11)
[Abstract] Objective: To update and expand upon prior Osteoarthritis Research Society International (OARSI) guidelines by developing patient-focused treatment recommendations for individuals with Knee, Hip, and Polyarticular ...
Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
(BMJ, 2015-01-14)
[Abstract] Objectives. To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain.
Methods. Double-blind ...
Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress
(BMC, 2017-06-12)
[Abstract] Background, Currently, two pathogenic pathways describe the role of obesity in osteoarthritis (OA); one through biomechanical stress, and the other by the contribution of systemic inflammation. The aim of this ...
Mitochondrial haplogroups H and J: risk and protective factors for ischemic cardiomyopathy
(PLoS, 2012-08-28)
[Abstract] Background. Since mitochondria are the principal source of reactive oxygen species (ROS), these organelles may play an important role in ischemic cardiomyopathy (IC) development. The mitochondrial genome may ...
Plasma mitochondrial DNA levels are inversely associated with HIV-RNA levels and directly with CD4 counts: potential role as a biomarker of HIV replication
(Oxford, 2017-08-31)
[Abstract] Objectives. To evaluate plasma mitochondrial DNA (mtDNA) levels among HIV-infected patients and its potential role as a biomarker of residual viral replication.
Methods. HIV-infected patients on follow-up at a ...
Prevalence of Systemic Lupus Erythematosus in Spain: Higher than Previously Reported in Other Countries?
(Oxford, 2020-01-30)
[Abstract] Objectives: Prevalence of SLE varies among studies, being influenced by study design, geographical area and ethnicity. Data about the prevalence of SLE in Spain are scarce. In the EPISER2016 study, promoted by ...
Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1
(Nature, 2015-05-21)
[Abstract] Article
Open Access
Published: 21 May 2015
Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1
Adrian Cortes, Sara L. Pulit, Paul J. ...