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Mitochondrial DNA haplogroups associated with MRI-detected structural damage in early knee osteoarthritis
(Elsevier, 2018-07-20)
[Abstract] Objective: Magnetic resonance imaging (MRI)-detected structural features are associated with increased risk of radiographic osteoarthritis (ROA). Specific mitochondrial DNA (mtDNA) haplogroups have been associated ...
Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis
(BioMed Central, 2011-11-22)
[Abstract] Background: Oxidative stress play a main role in the initiation and progression of the OA disease and leads to the degeneration of mitochondria. To prevent this, the chondrocytes possess a well-coordinated ...
Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts: a meta-analysis and functional study
(BMJ, 2016-12-05)
[Abstract] Objective To evaluate the influence of the mitochondrial DNA (mtDNA) haplogroups in the risk of incident knee osteoarthritis (OA) and to explain the functional consequences of this association to identify potential ...
Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative
(BMJ, 2019-08-30)
[Abstract] Objective To find autoantibodies (AAbs) in serum that could be useful to predict incidence of radiographic knee osteoarthritis (KOA).
Design A Nucleic-acid Programmable Protein Arrays (NAPPA) platform was ...
Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies
(Wiley, 2013-12-10)
[Abstract] Objective: To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA.
Methods: A total of 199 ...
Mitochondrial haplogroups define two phenotypes of osteoarthritis
(Frontiers, 2012-05-11)
[Abstract] Objective: To assess a mitochondrion-related phenotype in patients with osteoarthritis (OA).
Methods: Serum levels of the following OA-related biomarkers: matrix metalloproteinase-1 (MMP-1); MMP-3; MMP-13; ...
Higher synovial immunohistochemistry reactivity of IL-17A, Dkk1, and TGF-β1 in patients with early psoriatic arthritis and rheumatoid arthritis could predict the use of biologics
(MDPI, 2024-04-08)
[Abstract] Background: Delay in diagnosis and therapy in patients with arthritis commonly leads to progressive articular damage. The study aimed to investigate the immunohistochemical reactivity of synovial cytokines ...
Defective chaperone-mediated autophagy is a hallmark of joint disease in patients with knee osteoarthritis
(Elsevier, 2023-03-08)
[Abstract] Objective: Defects in autophagy contribute to joint aging and Osteoarthritis (OA). Identifying specific autophagy types could be useful for developing novel treatments for OA.
Design: An autophagy-related ...
Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect
(BMJ, 2023-03-17)
[Abstract] Objectives: Erosive hand osteoarthritis (EHOA) is a severe subset of hand osteoarthritis (OA). It is unclear if EHOA is genetically different from other forms of OA. Sequence variants at ten loci have been ...
Increased synovial immunohistochemistry reactivity of TGF-β1 in erosive peripheral psoriatic arthritis
(BioMed Central, 2023-03-30)
[Abstract] Background: Immune and non-immune cells contribute to the pathology of chronic arthritis, and they can contribute to tissue remodeling and repair as well as disease pathogenesis. The present research aimed to ...