Listar GI-TCMR - Artigos por título
Mostrando ítems 71-90 de 130
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Intraarticular administration effect of hydrogen sulfide on an in vivo rat model of osteoarthritis
(MDPI, 2020-10-08)[Abstract] Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological ... -
Is myofascial release therapy cost-effective when compared with manual therapy to treat workers’ mechanical neck pains?
(Elsevier, 2020-09-12)[Abstract] Objective: The aim of this study was to do a cost-benefit analysis of myofascial release therapy (MRT) compared to manual therapy (MT) for treating occupational mechanical neck pain. Methods: Variables regarding ... -
Isolation and characterization of mesenchymal stem cells from human amniotic membrane
(Mary Ann Liebert, 2011-01-04)[Abstract] Introduction: The human amniotic membrane is a highly abundant and readily available tissue that may be useful for regenerative medicine and cell therapy. Aim: To compare two previously published protocols for ... -
iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis
(BioMed Central, 2015-06-12)[Abstract] Introduction. Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging ... -
Lamin A deregulation in human mesenchymal stem cells promotes an impairment in their chondrogenic potential and imbalance in their response to oxidative stress
(Elsevier, 2013-07-26)[Abstract] In the present study, we examined the effect of the over-expression of LMNA, or its mutant form progerin (PG), on the mesoderm differentiation potential of mesenchymal stem cells (MSCs) from human umbilical cord ... -
Lesions associated with calcium gluconate extravasation: presentation of 5 clinical cases and analysis of cases published
(Wolters Kluwer, 2017-11)[Abstract] Introduction: Calcium gluconate extravasation is a process, which, while not common, occurs more frequently in neonatal intensive care units. The aim of this study is to present a number of cases of calcium ... -
Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro
(Elsevier, 2017-08-15)[Abstract] Healthy cartilage maintenance relies on an equilibrium among the anabolic and catabolic processes in chondrocytes. With the onset of osteoarthritis (OA), increased interleukin (IL)-1β levels induce an inhibition ... -
Medicina termal en enfermedades reumáticas: evidencia científica y actualidad de los mecanismos de acción
(Sociedad Española de Hidrología Médica, 2020)[Resumen] La patología músculo-esquelética es la responsable en la actualidad de la mayoría de las prescripciones de la curas termales en diversos países. La eficacia de la balneoterapia en reumatología, ha sido confirmada ... -
Mesenchymal stem cell therapy in traumatic spinal cord injury: a systematic review
(MDPI, 2023-07-20)[Abstract] Recovery from a traumatic spinal cord injury (TSCI) is challenging due to the limited regenerative capacity of the central nervous system to restore cells, myelin, and neural connections. Cell therapy, particularly ... -
Mesenchymal stromal cells for articular cartilage repair: preclinical studies
(AO Research Institute Davos (ARI), 2020-08-26)[Abstract] Rheumatic diseases such as osteoarthritis (OA) are a major social and economic burden because of the population aging and the lack of curative solutions. An effective cell therapy may be the best treatment ... -
Methylphenidate promotes premature growth plate closure: in vitro evidence
(MDPI, 2023-02-20)[Abstract] It is well known that patients with attention deficit hyperactivity disorder treated with stimulants, such as methylphenidate hydrochloride (MPH), have reduced height and weight. Even though MPH has an anorexigenic ... -
Mitochondrial activity is modulated by TNFα and IL-1β in normal human chondrocyte cells
(Elsevier, 2006-05-05)[Abstract] Objective. Pro-inflammatory cytokines play an important role in osteoarthritis (OA). In osteoarthritic cartilage, chondrocytes exhibit an alteration in mitochondrial activity. This study analyzes the effect of ... -
Molecular profile and cellular characterization of human bone marrow mesenchymal stem cells: donor influence on chondrogenesis
(Elsevier, 2010)[Abstract] Background. The use of autologous or allogenic stem cells has recently been suggested as an alternative therapeutic approach for treatment of cartilage defects. Bone marrow mesenchymal stem cells (BM-MSCs) are ... -
Multilineage differentiation potential of cells isolated from the human amniotic membrane
(Wiley, 2010-11-01)[Abstract] The human amniotic membrane (HAM) contains two cell types from different embryological origins. Human amnion epithelial cells (hAECs) are derived from the embryonic ectoderm, while human amnion mesenchymal stromal ... -
Myofascial release therapy in the treatment of occupational mechanical neck pain: a randomized parallel group study
(Wolters Kluwer, 2016-07)[Abstract] Objective: As myofascial release therapy is currently under development, the objective of this study was to compare the effectiveness of myofascial release therapy with manual therapy for treating occupational ... -
Neurological recovery after traumatic spinal cord injury: prognostic value of magnetic resonance
(Nature, 2022-02-01)[Abstract] Study design: Retrospective observational study. Objectives: Assess the relationship between Magnetic Resonance (MR) image patterns and neurological recovery in patients with Traumatic Spinal Cord Injury ... -
Next-generation sequencing and quantitative proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging
(PLOS, 2018-10-31)[Abstract] Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for accelerated aging. Although the causal agent, a point mutation in LMNA gene, was identified more than a decade ago, the ... -
NF-κB/IKK Activation by Small Extracellular Vesicles Within the SASP
(Wiley, 2021-06-29)[Abstract] Cellular senescence plays an important role in different biological and pathological conditions. Senescent cells communicate with their microenvironment through a plethora of soluble factors, metalloproteases ... -
Niosomes-Based Gene Delivery Systems for Effective Transfection of Human Mesenchymal Stem Cells
(Elsevier, 2021-07-11)[Abstract] Gene transfer to mesenchymal stem cells (MSCs) has arisen as a powerful approach to increase the therapeutic potential of this effective cell population. Over recent years, niosomes have emerged as self-assembled ... -
Notch signalling in cancer stem cells
(Springer, 2009)[Abstract] A new theory about the development of solid tumours is emerging from the idea that solid tumours, like normal adult tissues, contain stem cells (called cancer stem cells) and arise from them. Genetic mutations ...