Listar GI-TCMR - Artigos por título

Mostrando ítems 45-64 de 123

    • Formononetin, a beer polyphenol with catabolic effects on chondrocytes 

      Guillán-Fresco, María; Franco-Trepat, Eloi; Alonso-Pérez, Ana; Jorge-Mora, Alberto; López-López, Verónica; Pazos-Pérez, Andrés; Piñeiro-Ramil, María; Gómez, Rodolfo (MDPI, 2023-06-29)
      [Abstract] Beer consumption has been identified as a risk factor for osteoarthritis (OA), a rheumatic disease characterised by cartilage degradation, joint inflammation, and eventual joint failure. One of the main isoflavonoids ...

    • Gene expression and functional comparison between multipotential stromal cells from lateral and medial condyles of knee osteoarthritis patients 

      Sanjurjo-Rodríguez, Clara; Baboolal, Thomas G.; Burska, Agata N.; Ponchel, Frederique; El-Jawhari, Jehan J.; Pandit, Hemant; McGonagle, Dennis; Jones, Elena (Nature Publishing Group, 2019-06-29)
      [Abstract] Osteoarthritis (OA) is the most common degenerative joint disorder. Multipotential stromal cells (MSCs) have a crucial role in joint repair, but how OA severity affects their characteristics remains unknown. ...

    • Gene Expression Signatures of Synovial Fluid Multipotent Stromal Cells in Advanced Knee Osteoarthritis and Following Knee Joint Distraction 

      Sanjurjo-Rodríguez, Clara; Altaie, Ala; Mastbergen, Simon; Baboolal, Thomas G.; Welting, Tim; Lafeber, Floris; Pandit, Hemant; McGonagle, Dennis; Jones, Elena (Frontiers Media S.A., 2020-10-14)
      [Abstract] Osteoarthritis (OA) is the most common musculoskeletal disorder. Although joint replacement remains the standard of care for knee OA patients, knee joint distraction (KJD), which works by temporarily off-loading ...

    • Generation and Characterization of Human Induced Pluripotent Stem Cells (iPSCs) From Hand Osteoarthritis Patient-Derived Fibroblasts 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Rodríguez-Fernández, Silvia; Oreiro, Natividad; De-Toro, Javier; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (Nature Research, 2020-03-06)
      [Abstract] Knowledge and research results about hand osteoarthritis (hOA) are limited due to the lack of samples and animal models of the disease. Here, we report the generation of two induced pluripotent stem cell ...

    • Generation of a human control iPS cell line (ESi080‐A) from a donor with no rheumatic diseases 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Rodríguez-Fernández, Silvia; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (Elsevier, 2020-03)
      [Abstract] Here, we report the establishment of the human iPS cell line N1-FiPS4F#7 generated from skin cells of a patient with no rheumatic diseases, thus obtaining an appropriate control iPS cell line for researchers ...

    • Generation of human immortalized chondrocytes from osteoarthritic and healthy cartilage 

      Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Hermida-Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Vaamonde-García, Carlos; Díaz-Prado, Silvia (The British Editorial Society of Bone & Joint Surgery, 2023-01-17)
      [Abstract] Aims. After a few passages of in vitro culture, primary human articular chondrocytes undergo senescence and loss of their phenotype. Most of the available chondrocyte cell lines have been obtained from cartilage ...

    • Generation of mesenchymal cell lines derived from aged donors 

      Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (MDPI, 2021-10-01)
      [Abstract] Background: Mesenchymal stromal cells (MSCs) have the capacity for self-renewal and multi-differentiation, and for this reason they are considered a potential cellular source in regenerative medicine of cartilage ...

    • Genome Wide CRISPR/Cas9 Screen Identifies the Coagulation Factor IX (F9) as a Regulator of Senescence 

      Carpintero-Fernández, Paula; Borghesan, Michela; Eleftheriadou, Olga; Pan-Castillo, Belén; Fafián Labora, Juan Antonio; Mitchell, Tom P.; Yuste, Alejandro; Ogrunc, Muge; Nightingale, Thomas D.; Mayán, María; O'Loghlen, Ana (Nature, 2022-02-19)
      [Abstract] During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce ...

    • Global DNA Methylation in Dental Implant Failure Due to Peri-Implantitis: An Exploratory Clinical Pilot Study 

      Khouly, Ismael; Pardiñas López, Simón; Díaz-Prado, Silvia; Ferrantino, Luca; Kalm, Josephine; Larsson, Lena; Asa'ad, Farah (MDPI, 2022-01-17)
      [Abstract] Background: Peri-implantitis (PIT) is highly prevalent in patients with dental implants and is a challenging condition to treat due to the limited outcomes reported for non-surgical and surgical therapies. ...

    • Hedgehog signalling as a target in cancer stem cells 

      Medina Villaamil, Vanessa; Blanco, Moisés; Díaz-Prado, Silvia; Espada, Jesús (Spirnger, 2009)
      [Abstract] Hedgehog (Hh) is one of the most important signalling pathways. Together with the Wnt, TGF-β/BMP and Notch pathways, it is involved in both embryonic development and adult tissue homeostasis. This is because Hh ...

    • High-Throughput Screen Detects Calcium Signaling Dysfunction in Hutchinson-Gilford Progeria Syndrome 

      Fafián Labora, Juan Antonio; Morente López, Miriam; De-Toro, Javier; Arufe, M.C. (MDPI, 2021-07-07)
      [Abstract] Hutchinson–Gilford progeria syndrome (HGPS) is a deadly childhood disorder, which is considered a very rare disease. It is caused by an autosomal dominant mutation on the LMNA gene, and it is characterized by ...

    • Human amniotic membrane as an alternative source of stem cells for regenerative medicine 

      Díaz-Prado, Silvia; Muiños-López, Emma; Hermida Gómez, Tamara; Cicione, Claudia; Rendal Vázquez, María Esther; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Elsevier, 2011-02-19)
      [Abstract] The human amniotic membrane (HAM) is a highly abundant and readily available tissue. This amniotic tissue has considerable advantageous characteristics to be considered as an attractive material in the field of ...

    • Human amniotic mesenchymal stromal cells as favorable source for cartilage repair 

      Muiños-López, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (Mary Ann Liebert, 2017-01-10)
      [Abstract] Introduction: Localized trauma-derived breakdown of the hyaline articular cartilage may progress toward osteoarthritis, a degenerative condition characterized by total loss of articular cartilage and joint ...

    • Human cartilage engineering in an in vitro repair model using collagen scaffolds and mesenchymal stromal cells 

      Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (Ivyspring, 2017-09-28)
      [Abstract] The purpose of this study was to investigate cartilage repair of in vitro lesion models using human bone marrow mesenchymal stromal cells (hBMSCs) with different collagen (Col) scaffolds. Lesions were made ...

    • Hydrogel-based localized nonviral gene delivery in regenerative medicine approaches: an overview 

      Carballo-Pedrares, Natalia; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Rey-Rico, Ana (MDPI, 2020-08-10)
      [Abstract] Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders ...

    • Hydrogen sulfide and inflammatory joint diseases 

      Burguera, Elena F.; Meijide-Faílde, Rosa; Blanco García, Francisco J (Bentham, 2017)
      [Abstract] Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with ...

    • Identification of patients at risk of non-adherence to oral antirheumatic drugs in rheumatoid arthritis using the Compliance Questionnaire in Rheumatology: an ARCO sub-study 

      Marras, Carlos; Monteagudo, Indalecio; Salvador, Georgina; De-Toro, Javier; Escudero, Alejandro; Alegre-Sancho, Juan J.; Raya, Enrique; Ortiz, Ana; Carmona, Loreto; Mestre, Yvonne; Cea-Calvo, Luis; Calvo-Alén, Jaime (Springer, 2017-05-17)
      [Abstract] The ARCO study (Study on Adherence of Rheumatoid Arthritis patients to SubCutaneous and Oral Drugs), a multicenter, non-interventional retrospective study, was primarily designed to assess the percentage of ...

    • Immortalizing mesenchymal stromal cells from aged donors while keeping their essential features 

      Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Hermida Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (Hindawi, 2020-06-16)
      [Abstract] Human bone marrow-derived mesenchymal stromal cells (MSCs) obtained from aged patients are prone to senesce and diminish their differentiation potential, therefore limiting their usefulness for osteochondral ...

    • In vitro study of the therapeutic potential of brown crude fucoidans in osteoarthritis treatment 

      Vaamonde-García, Carlos; Capelo Mera, Emma; Flórez-Fernández, Noelia; Torres, María Dolores; Rivas-Murias, Beatriz; Meijide-Faílde, Rosa; Blanco García, Francisco J; Domínguez, Herminia (MDPI, 2022-11-17)
      [Abstract] Osteoarthritis, one of the most common joint degenerative pathologies, still has no cure, and current treatments, such as nonsteroidal anti-inflammatory drugs, can cause serious adverse effects when taken for a ...

    • Induced pluripotent stem cells for cartilage repair: current status and future perspectives 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (AO Research Institute Davos, 2018-09-11)
      [Abstract] The establishment of cartilage regenerative medicine is an important clinical issue, but the search for cell sources able to restore cartilage integrity proves to be challenging. Human mesenchymal stromal cells ...