Now showing items 1-20 of 125

    • Mitochondrial activity is modulated by TNFα and IL-1β in normal human chondrocyte cells 

      López-Armada, María José; Caramés, Beatriz; Martín, M.A.; Cillero-Pastor, B.; Lires-Dean, M.; Fuentes Boquete, Isaac Manuel; Arenas, J.; Blanco García, Francisco J (Elsevier, 2006-05-05)
      [Abstract] Objective. Pro-inflammatory cytokines play an important role in osteoarthritis (OA). In osteoarthritic cartilage, chondrocytes exhibit an alteration in mitochondrial activity. This study analyzes the effect of ...
    • Prostate cancer and Hedgehog signalling pathway 

      Antón-Aparicio, Luis M.; García Campelo, Rosario; Casinello Espinosa, J.; Valladares-Ayerbes, Manuel; Reboredo, Margarita; Díaz-Prado, Silvia; Aparicio Gallego, Guadalupe (Springer, 2007-08-02)
      [Abstract] The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, ...
    • Cyclooxygenase-2 (COX-2): a molecular target in prostate cancer 

      Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Jiménez Fonseca, P.; García Campelo, Rosario; Casinello Espinosa, J.; Antón-Aparicio, Luis M. (Springer, 2007-12-15)
      [Abstract] Epidemiological studies provided the first evidence that COX may be involved in the pathogenesis of cancer. In the process of carcinogenesis and in the route of intracellular signalling during carcinogenesis, ...
    • Cell and Tissue Transplant Strategies for Joint Lesions 

      Fuentes Boquete, Isaac Manuel; Arufe, M.C.; Díaz-Prado, Silvia; Hermida Gómez, Tamara; De-Toro, Javier; Blanco García, Francisco J (Bentham Open, 2008-07-11)
      [Abstract] Articular cartilage lesions that do not disrupt the integrity of subchondral bone are not capable of spontaneous repair. The asymptomatic nature of these lesions leads to articular cartilage degeneration and ...
    • Tratamiento de lesiones del cartílago articular con terapia celular 

      Fuentes Boquete, Isaac Manuel; Arufe, M.C.; Díaz-Prado, Silvia; Hermida Gómez, Tamara; De-Toro, Javier; Blanco García, Francisco J (Elsevier, 2008-11-13)
      [Resumen] Las lesiones del cartílago articular que no afectan a la integridad del hueso subcondral no se reparan espontáneamente. El carácter asintomático de estas lesiones propicia la progresiva degeneración articular y ...
    • Origin of renal cell carcinomas 

      Valladares-Ayerbes, Manuel; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Jiménez Fonseca, P.; García Campelo, Rosario; Antón-Aparicio, Luis M. (Springer, 2008-11-28)
      [Abstract] Cancer is a heritable disorder of somatic cells: environment and heredity are both important in the carcinogenic process. The primal force is the “two hits” of Knudson’s hypothesis, which has proved true for ...
    • Hedgehog signalling as a target in cancer stem cells 

      Medina Villaamil, Vanessa; Blanco, Moisés; Díaz-Prado, Silvia; Espada, Jesús (Spirnger, 2009)
      [Abstract] Hedgehog (Hh) is one of the most important signalling pathways. Together with the Wnt, TGF-β/BMP and Notch pathways, it is involved in both embryonic development and adult tissue homeostasis. This is because Hh ...
    • Notch signalling in cancer stem cells 

      Bolós Fernández, Victoria; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Grande Pulido, Enrique (Springer, 2009)
      [Abstract] A new theory about the development of solid tumours is emerging from the idea that solid tumours, like normal adult tissues, contain stem cells (called cancer stem cells) and arise from them. Genetic mutations ...
    • La ciclooxigenasa-2 (COX-2) y el factor de crecimiento epidérmico (EFG) en lesiones epiteliales orales premalignas 

      Díaz-Prado, Silvia; Antón-Aparicio, Luis M.; Gallego Guadalupe, A.; López-Cedrún Cembranos, José Luis; Ferreras Granado, José (Sociedad Española de Cirugía Oral y Maxilofacial (SECOM), 2009)
      [Resumen] Las lesiones premalignas orales incluyen eritroplasias (manchas rojas) y leucoplasias (manchas blancas), las cuales se desarrollan a lo largo de superficies epiteliales. Estas lesiones son considerados marcadores ...
    • Biology of BMP signalling and cancer 

      Blanco, Moisés; Bolós Fernández, Victoria; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Grande Pulido, Enrique (Springer, 2009)
      [Abstract] In recent years, it has been proposed that tumours are not homogeneous but composed of several cellular types like normal tissues. A cellular subtype, which is though to be the origin of tumours as well as their ...
    • Expression of Wnt gene family and frizzled receptors in head and neck squamous cell carcinomas 

      Díaz-Prado, Silvia; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Blanco, Moisés; López Cedrún, José Luis; Sironvalle Soliva, Sheila; Valladares-Ayerbes, Manuel; García Campelo, Rosario; Antón-Aparicio, Luis M. (Spirnger, 2009)
      [Abstract] Genes of the Wnt and Frizzled class, expressed in HNSCC tissue and cell lines, have an established role in cell morphogenesis and differentiation, and also they have oncogenic properties. We studied Wnt and Fz ...
    • Spanish adaptation of the Stroke and Aphasia Quality of Life Scale-39 (SAQOL-39) 

      Lata-Caneda, M.C.; Piñeiro-Temprano, M.; García-Fraga, I.; García-Armesto, I.; Barrueco-Egido, J.R.; Meijide-Faílde, Rosa (Minerva Médica, 2009-01-21)
      [Abstract] Aim. The stroke and aphasia quality of life scale-39 is an interviewer administered questionnaire that has been developed and validated in the United Kingdom to be applied to patients with chronic aphasia as a ...
    • Differentiation of Murine Embryonic Stem Cells to Thyrocytes Requires Insulin and Insulin-like Growth Factor-1 

      Arufe, M.C.; Lu, Min; Lin, Reigh-Yi (Elsevier, 2009-02-14)
      [Abstract] The mechanisms controlling thyrocyte development during embryonic stem (ES) cell differentiation have only been partially elucidated, although previous studies have suggested the participation of thyroid stimulating ...
    • Differentiation of Synovial CD-105+ Human Mesenchymal Stem Cells into Chondrocyte-like Cells through Spheroid Formation 

      Arufe, M.C.; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Wiley, 2009-06-18)
      [Abstract] Mesenchymal stem cells (MSCs) have the capacity to differentiate into several cell lineages, some of which can generate bone, cartilage, or adipose tissue. The presence of MSCs in the synovial membrane was ...
    • Wnt signalling and cancer stem cells 

      Espada, Jesús; Calvo, Moisés B.; Díaz-Prado, Silvia; Medina, Vanessa (Springer, 2009-07-15)
      [Abstract] Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and ...
    • Molecular profile and cellular characterization of human bone marrow mesenchymal stem cells: donor influence on chondrogenesis 

      Cicione, Claudia; Díaz-Prado, Silvia; Muiños-López, Emma; Hermida Gómez, Tamara; Blanco García, Francisco J (Elsevier, 2010)
      [Abstract] Background. The use of autologous or allogenic stem cells has recently been suggested as an alternative therapeutic approach for treatment of cartilage defects. Bone marrow mesenchymal stem cells (BM-MSCs) are ...
    • Potential use of the human amniotic membrane as a scaffold in human articular cartilage repair 

      Díaz-Prado, Silvia; Rendal Vázquez, María Esther; Muiños-López, Emma; Hermida Gómez, Tamara; Rodríguez-Cabarcos, Margarita; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Springer, 2010-04-13)
      [Abstract] The human amniotic membrane (HAM) is an abundant and readily obtained tissue that may be an important source of scaffold for transplanted chondrocytes in cartilage regeneration in vivo. To evaluate the potential ...
    • Evaluation of Plakophilin-3 mRNA as a biomarker for detection of circulating tumor cells in gastrointestinal cancer patients 

      Valladares-Ayerbes, Manuel; Díaz-Prado, Silvia; Reboredo, Margarita; Medina, Vanessa; Lorenzo-Patiño, María J.; Iglesias-Díaz, Pilar; Haz, Mar; Pértega-Díaz, Sonia; Santamarina, Isabel; Blanco, Moisés; Quindós-Varela, María; Figueroa, Angélica; Antón-Aparicio, Luis M. (American Association for Cancer Research, 2010-05-25)
      [Abstract] Background: This study aims to assess Plakophilin-3 (PKP3) as a surrogate biomarker of circulating tumor cells in patients with gastrointestinal cancer. Methods: The primary aim is to estimate the diagnostic ...
    • Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias 

      Díaz-Prado, Silvia; López Cedrún, José Luis; Luaces Rey, Ramón; Medina Villaamil, Vanessa; Álvarez García, Augusto; Valladares-Ayerbes, Manuel; Antón-Aparicio, Luis M. (Elsevier, 2010-07-01)
      [Abstract] Objective. Identify candidate SEBs (surrogate endpoint biomarkers) for premalignant trends in head and neck mucosa. Study design. Study, by qPCR (quantitative real-time polymerase chain reaction), the expression ...
    • Chondrogenic Potential of Subpopulations of Cells Expressing Mesenchymal Stem Cell Markers Derived from Human Synovial Membranes 

      Arufe, M.C.; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Wiley, 2010-07-21)
      [Abstract] In this study we analyzed the chondrogenic potential of subpopulations of mesenchymal stem cells (MSCs) derived from human synovial membranes enriched for CD73, CD106, and CD271 markers. Subpopulations of human ...