Recent Submissions

  • Gene expression and functional comparison between multipotential stromal cells from lateral and medial condyles of knee osteoarthritis patients 

    Sanjurjo-Rodríguez, Clara; Baboolal, Thomas G.; Burska, Agata N.; Ponchel, Frederique; El-Jawhari, Jehan J.; Pandit, Hemant; McGonagle, Dennis; Jones, Elena (Nature Publishing Group, 2019-06-29)
    [Abstract] Osteoarthritis (OA) is the most common degenerative joint disorder. Multipotential stromal cells (MSCs) have a crucial role in joint repair, but how OA severity affects their characteristics remains unknown. ...
  • Effect of aging on behaviour of mesenchymal stem cells 

    Fafián Labora, Juan Antonio; Morente-López, Miriam; Arufe, María C. (Baishideng Publishing Group Inc., 2019-06-26)
    [Abstract] Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult ...
  • Hydrogen sulfide and inflammatory joint diseases 

    Burguera, E.F.; Meijide-Failde, Rosa; Blanco García, Francisco J (Bentham, 2017)
    [Abstract] Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with ...
  • Next-generation sequencing and quantitative proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging 

    Mateos, Jesús; Fafián Labora, Juan Antonio; Morente-López, Miriam; Lesende-Rodríguez, Iván; Monserrat Iglesias, Lorenzo; Ódena, María A.; Oliveira, Eliandre de; Toro Santos, Francisco Javier de; Arufe, María C. (PLOS, 2018-10-31)
    [Abstract] Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for accelerated aging. Although the causal agent, a point mutation in LMNA gene, was identified more than a decade ago, the ...
  • Induced pluripotent stem cells for cartilage repair: current status and future perspectives 

    Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Toro Santos, Francisco Javier de; Blanco García, Francisco J; Díaz Prado, Silvia (AO Research Institute Davos, 2018-09-11)
    [Abstract] The establishment of cartilage regenerative medicine is an important clinical issue, but the search for cell sources able to restore cartilage integrity proves to be challenging. Human mesenchymal stromal cells ...

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