• Generation and characterization of human induced pluripotent stem cells (iPSCs) from hand osteoarthritis patient-derived fibroblasts 

  Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Rodríguez-Fernández, Silvia; Oreiro, Natividad; Toro Santos, Francisco Javier de; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J.; Díaz Prado, Silvia (Nature Research, 2020-03-06)

  [Abstract] Knowledge and research results about hand osteoarthritis (hOA) are limited due to the lack of samples and animal models of the disease. Here, we report the generation of two induced pluripotent stem cell ...

• Influence of mesenchymal stem cell-derived extracellular vesicles in vitro and their role in ageing 

  Fafián Labora, Juan Antonio; Morente-López, Miriam; Sánchez-Dopico, María José; Arntz, O.J.; Van de Loo, F.J.; Toro Santos, Francisco Javier de; Arufe, María C. (Springer Nature, 2020-01-03)

  [Abstract] Introduction: This study assessed whether mesenchymal stem cell (MSC)-derived extracellular vesicles influenced ageing and pluripotency markers in cell cultures where they are added. Methods: MSC-derived ...

• Usefulness of mesenchymal cell lines for bone and cartilage regeneration research 

  Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Rodríguez-Fernández, Silvia; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz Prado, Silvia (MDPI, 2019-12-13)

  [Abstract] The unavailability of sufficient numbers of human primary cells is a major roadblock for in vitro repair of bone and/or cartilage, and for performing disease modelling experiments. Immortalized mesenchymal ...

• Gene expression and functional comparison between multipotential stromal cells from lateral and medial condyles of knee osteoarthritis patients 

  Sanjurjo-Rodríguez, Clara; Baboolal, Thomas G.; Burska, Agata N.; Ponchel, Frederique; El-Jawhari, Jehan J.; Pandit, Hemant; McGonagle, Dennis; Jones, Elena (Nature Publishing Group, 2019-06-29)

  [Abstract] Osteoarthritis (OA) is the most common degenerative joint disorder. Multipotential stromal cells (MSCs) have a crucial role in joint repair, but how OA severity affects their characteristics remains unknown. ...

• Effect of aging on behaviour of mesenchymal stem cells 

  Fafián Labora, Juan Antonio; Morente-López, Miriam; Arufe, María C. (Baishideng Publishing Group Inc., 2019-06-26)

  [Abstract] Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult ...

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