• 15-Deoxy-Δ-12, 14-prostaglandin J2 acts cooperatively with prednisolone to reduce TGF-β-induced pro-fibrotic pathways in human osteoarthritis fibroblasts 

  Vaamonde-García, Carlos; Malaise, Olivier; Charlier, Edith; Deroyer, Céline; Neuville, Sophie; Gillet, Philippe; Kurth, William; Meijide-Faílde, Rosa; Malaise, Michel G.; de Seny, Dominique (Elsevier, 2019-03-29)

  [Abstract] Abstract Background/aims: Synovial fibrosis is a pathological process that is observed in several musculoskeletal disorders and characterized by the excessive deposition of extracellular matrix, as well as cell ...

• Remodeling of human osteochondral defects via rAAV-mediated co-overexpression of TGF-β and IGF-I from implanted human bone marrow-derived mesenchymal stromal cells 

  Morscheid, Stephanie; Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Schmitt, Gertrud; Cucchiarini, Magali (MDPI, 2019-08-28)

  [Abstract] The application of chondrogenic gene sequences to human bone marrow-derived mesenchymal stromal cells (hMSCs) is an attractive strategy to activate the reparative activities of these cells as a means to enhance ...

• Therapeutic effects of rAAV-mediated concomittant gene transfer and overexpression of TGF-β and IGF-I on the chondrogenesis of human bone-marrow-derived mesenchymal stem cells 

  Morscheid, Stephanie; Rey-Rico, Ana; Schmitt, Gertrud; Madry, Henning; Cucchiarini, Magali; Venkatesan, Jagadeesh Kumar (MDPI, 2019-05-27)

  [Abstract] Application of chondroreparative gene vectors in cartilage defects is a powerful approach to directly stimulate the regenerative activities of bone-marrow-derived mesenchymal stem cells (MSCs) that repopulate ...

• Generation of mesenchymal cell lines derived from aged donors 

  Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (MDPI, 2021-10-01)

  [Abstract] Background: Mesenchymal stromal cells (MSCs) have the capacity for self-renewal and multi-differentiation, and for this reason they are considered a potential cellular source in regenerative medicine of cartilage ...

• Classical and nonclassical intercellular communication in senescence and ageing 

  Fafián Labora, Juan Antonio; O'Loghlen, Ana (Cell Press, 2020-06-03)

  [Abstract] Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes ...

View more