• Usefulness of mesenchymal cell lines for bone and cartilage regeneration research 

  Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Rodríguez-Fernández, Silvia; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz Prado, Silvia (MDPI, 2019-12-13)

  [Abstract] The unavailability of sufficient numbers of human primary cells is a major roadblock for in vitro repair of bone and/or cartilage, and for performing disease modelling experiments. Immortalized mesenchymal ...

• Gene expression and functional comparison between multipotential stromal cells from lateral and medial condyles of knee osteoarthritis patients 

  Sanjurjo-Rodríguez, Clara; Baboolal, Thomas G.; Burska, Agata N.; Ponchel, Frederique; El-Jawhari, Jehan J.; Pandit, Hemant; McGonagle, Dennis; Jones, Elena (Nature Publishing Group, 2019-06-29)

  [Abstract] Osteoarthritis (OA) is the most common degenerative joint disorder. Multipotential stromal cells (MSCs) have a crucial role in joint repair, but how OA severity affects their characteristics remains unknown. ...

• Effect of aging on behaviour of mesenchymal stem cells 

  Fafián Labora, Juan Antonio; Morente-López, Miriam; Arufe, María C. (Baishideng Publishing Group Inc., 2019-06-26)

  [Abstract] Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult ...

• Hydrogen sulfide and inflammatory joint diseases 

  Burguera, E.F.; Meijide-Failde, Rosa; Blanco García, Francisco J (Bentham, 2017)

  [Abstract] Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with ...

• Next-generation sequencing and quantitative proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging 

  Mateos, Jesús; Fafián Labora, Juan Antonio; Morente-López, Miriam; Lesende-Rodríguez, Iván; Monserrat Iglesias, Lorenzo; Ódena, María A.; Oliveira, Eliandre de; Toro Santos, Francisco Javier de; Arufe, María C. (PLOS, 2018-10-31)

  [Abstract] Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for accelerated aging. Although the causal agent, a point mutation in LMNA gene, was identified more than a decade ago, the ...

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