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Wnt signalling and cancer stem cells
(Springer, 2009-07-15)
[Abstract] Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and ...
Prostate cancer and Hedgehog signalling pathway
(Springer, 2007-08-02)
[Abstract] The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, ...
Hedgehog signalling as a target in cancer stem cells
(Spirnger, 2009)
[Abstract] Hedgehog (Hh) is one of the most important signalling pathways. Together with the Wnt, TGF-β/BMP and Notch pathways, it is involved in both embryonic development and adult tissue homeostasis. This is because Hh ...
Mesenchymal stem cell therapy in traumatic spinal cord injury: a systematic review
(MDPI, 2023-07-20)
[Abstract] Recovery from a traumatic spinal cord injury (TSCI) is challenging due to the limited regenerative capacity of the central nervous system to restore cells, myelin, and neural connections. Cell therapy, particularly ...
Generation of human immortalized chondrocytes from osteoarthritic and healthy cartilage
(The British Editorial Society of Bone & Joint Surgery, 2023-01-17)
[Abstract] Aims. After a few passages of in vitro culture, primary human articular chondrocytes undergo senescence and loss of their phenotype. Most of the available chondrocyte cell lines have been obtained from cartilage ...
Global DNA Methylation in Dental Implant Failure Due to Peri-Implantitis: An Exploratory Clinical Pilot Study
(MDPI, 2022-01-17)
[Abstract] Background: Peri-implantitis (PIT) is highly prevalent in patients with dental implants and is a challenging condition to treat due to the limited outcomes reported for non-surgical and surgical therapies. ...
Human amniotic mesenchymal stromal cells as favorable source for cartilage repair
(Mary Ann Liebert, 2017-01-10)
[Abstract]
Introduction: Localized trauma-derived breakdown of the hyaline articular cartilage may progress toward osteoarthritis, a degenerative condition characterized by total loss of articular cartilage and joint ...
Biomedical Applications of the Biopolymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Drug Encapsulation and Scaffold Fabrication
(MDPI, 2023-07-19)
[Abstract] Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a biodegradable and biocompatible biopolymer that has gained popularity in the field of biomedicine. This review provides an overview of recent advances and ...
Hydrogel-based localized nonviral gene delivery in regenerative medicine approaches: an overview
(MDPI, 2020-08-10)
[Abstract]
Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various
regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular,
or neural tissues disorders ...
An artificial-vision- and statistical-learning-based method for studying the biodegradation of type I collagen scaffolds in bone regeneration systems
(PeerJ, 2019-07-05)
[Abstract]
This work proposes a method based on image analysis and machine and statistical learning to model and estimate osteocyte growth (in type I collagen scaffolds for bone regeneration systems) and the collagen ...