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Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes
(Elsevier, 2014-07)
[Abstract] Objective. Hydrogen sulfide (H2S), the third gasotransmitter together with NO and CO, is emerging as a regulator of inflammation. To test if it might offer therapeutic value in the treatment of osteoarthritis ...
Regulation of Angiogenesis Discriminates Tissue Resident MSCs from Effective and Defective Osteogenic Environments
(MDPI, 2020-05-28)
[Abstract] Background: The biological mechanisms that contribute to atrophic long bone non-union
are poorly understood. Multipotential mesenchymal stromal cells (MSCs) are key contributors to bone
formation and are ...
NF-κB/IKK Activation by Small Extracellular Vesicles Within the SASP
(Wiley, 2021-06-29)
[Abstract] Cellular senescence plays an important role in different biological and pathological conditions. Senescent cells communicate with their microenvironment through a plethora of soluble factors, metalloproteases ...
Myofascial release therapy in the treatment of occupational mechanical neck pain: a randomized parallel group study
(Wolters Kluwer, 2016-07)
[Abstract] Objective: As myofascial release therapy is currently under development, the objective of this study was to compare the effectiveness of myofascial release therapy with manual therapy for treating occupational ...
Wnt signalling and cancer stem cells
(Springer, 2009-07-15)
[Abstract] Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and ...
Study of ferroptosis transmission by small extracellular vesicles in epithelial ovarian cancer cells
(MDPI, 2023-01-12)
[Abstract] Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. The current treatment for EOC involves surgical debulking of the tumors followed by a combination of chemotherapy. While most patients ...
Epidemiology of traumatic spinal cord injury in Galicia, Spain: trends over a 20-year period
(Nature, 2017-02-14)
[Abstract] Study design: Observational study with prospective and retrospective monitoring.
Objective: To describe the epidemiological and demographic characteristics of traumatic spinal cord injury (TSCI), and to analyze ...
Biodistribution and Immunogenicity of Allogeneic Mesenchymal Stem Cells in a Rat Model of Intraarticular Chondrocyte Xenotransplantation
(Frontiers, 2017-11-06)
[Abstract] Xenogeneic chondrocytes and allogeneic mesenchymal stem cells (MSC) are considered a potential source of cells for articular cartilage repair. We here assessed the immune response triggered by xenogeneic ...
Prostate cancer and Hedgehog signalling pathway
(Springer, 2007-08-02)
[Abstract] The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, ...
Valor pronóstico de la resonancia magnética precoz en la morbilidad y mortalidad de la lesión medular traumática
(Elsevier, 2022-02-12)
[Resumen] Objetivo. Valorar en individuos con lesión medular traumática (LMT) la relación entre la mortalidad y la necesidad de UCI y las alteraciones objetivadas mediante resonancia magnética (RM) precoz, analizando ...