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Action mechanisms of small extracellular vesicles in inflammaging
(MDPI, 2022-04-06)
[Abstract] The accumulation process of proinflammatory components in the body due to aging influences intercellular communication and is known as inflammaging. This biological mechanism relates the development of inflammation ...
Effect of miR-21 in mesenchymal stem cells-derived extracellular vesicles behavior
(BioMed Central, 2023-12-21)
[Abstract] Background: A challenging new branch of research related to aging-associated diseases is the identification of miRNAs capable of modulating the senescence-associated secretory phenotype (SASP) which characterizes ...
Study of ferroptosis transmission by small extracellular vesicles in epithelial ovarian cancer cells
(MDPI, 2023-01-12)
[Abstract] Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. The current treatment for EOC involves surgical debulking of the tumors followed by a combination of chemotherapy. While most patients ...
Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells
(MDPI, 2021-03-25)
[Abstract]
Mesenchymal stem cells have an important potential in the treatment of age-related diseases.
In the last years, small extracellular vesicles derived from these stem cells have been proposed as
cell-free ...
Genome Wide CRISPR/Cas9 Screen Identifies the Coagulation Factor IX (F9) as a Regulator of Senescence
(Nature, 2022-02-19)
[Abstract] During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce ...
Therapy free of cells vs human mesenchymal stem cells from umbilical cord stroma to treat the inflammation in OA
(Springer, 2022-10-20)
[Abstract] Osteoarthritis (OA) is closely linked to the increase in the number of senescent cells in joint tissues, and the senescence-associated secretory phenotype (SASP) is implicated in cartilage degradation. In the ...
High-Throughput Screen Detects Calcium Signaling Dysfunction in Hutchinson-Gilford Progeria Syndrome
(MDPI, 2021-07-07)
[Abstract] Hutchinson–Gilford progeria syndrome (HGPS) is a deadly childhood disorder, which is considered a very rare disease. It is caused by an autosomal dominant mutation on the LMNA gene, and it is characterized by ...
NF-κB/IKK Activation by Small Extracellular Vesicles Within the SASP
(Wiley, 2021-06-29)
[Abstract] Cellular senescence plays an important role in different biological and pathological conditions. Senescent cells communicate with their microenvironment through a plethora of soluble factors, metalloproteases ...
Classical and nonclassical intercellular communication in senescence and ageing
(Cell Press, 2020-06-03)
[Abstract] Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes ...
Extracellular Vesicles as Potential Tools for Regenerative Therapy
(Taylor & Francis Online, 2020-09-08)
[Abstract]
Small extracellular vesicles released by fibroblasts from young human donors diminish lipid peroxidation
in senescent cells and in different old mice organs due to their enrichment in Glutathione-S-transferase
Mu ...