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iTRAQ-Based Analysis of Progerin Expression Reveals Mitochondrial Dysfunction, Reactive Oxygen Species Accumulation and Altered Proteostasis
(BioMed Central, 2015-06-12)
[Abstract]
Introduction. Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging ...
Influence of Age on Rat Bone-Marrow Mesenchymal Stem Cells Potential
(Nature, 2015-11-19)
[Abstract] Mesenchymal stem cells promising role in cell-based therapies and tissue engineering appears to be limited due to a decline of their regenerative potential with increasing donor age. Six age groups from bone ...
Proteomic Applications in the Study of Human Mesenchymal Stem Cells
(Multidisciplinary Digital Publishing Institute, 2014-02-07)
Mesenchymal stem cells (MSCs) are undifferentiated cells with an unlimited capacity for self-renewal and able to differentiate towards specific lineages under appropriate conditions. MSCs are, a priori, a good target for ...
3, 3′, 5-triiodo-L-thyronine increases in vitro chondrogenesis of mesenchymal stem cells from human umbilical cord stroma through SRC2
(Wiley, 2016-07-08)
[Abstract] Our group focuses on the study of mesenchymal stem cells (MSCs) from human umbilical cord stroma or Warthońs jelly and their directed differentiation toward chondrocyte-like cells capable of regenerating damaged ...
Action mechanisms of small extracellular vesicles in inflammaging
(MDPI, 2022-04-06)
[Abstract] The accumulation process of proinflammatory components in the body due to aging influences intercellular communication and is known as inflammaging. This biological mechanism relates the development of inflammation ...
Effect of miR-21 in mesenchymal stem cells-derived extracellular vesicles behavior
(BioMed Central, 2023-12-21)
[Abstract] Background: A challenging new branch of research related to aging-associated diseases is the identification of miRNAs capable of modulating the senescence-associated secretory phenotype (SASP) which characterizes ...
Study of ferroptosis transmission by small extracellular vesicles in epithelial ovarian cancer cells
(MDPI, 2023-01-12)
[Abstract] Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. The current treatment for EOC involves surgical debulking of the tumors followed by a combination of chemotherapy. While most patients ...
Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells
(MDPI, 2021-03-25)
[Abstract]
Mesenchymal stem cells have an important potential in the treatment of age-related diseases.
In the last years, small extracellular vesicles derived from these stem cells have been proposed as
cell-free ...
Genome Wide CRISPR/Cas9 Screen Identifies the Coagulation Factor IX (F9) as a Regulator of Senescence
(Nature, 2022-02-19)
[Abstract] During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce ...
Therapy free of cells vs human mesenchymal stem cells from umbilical cord stroma to treat the inflammation in OA
(Springer, 2022-10-20)
[Abstract] Osteoarthritis (OA) is closely linked to the increase in the number of senescent cells in joint tissues, and the senescence-associated secretory phenotype (SASP) is implicated in cartilage degradation. In the ...