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Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes
(Elsevier, 2014-07)
[Abstract] Objective. Hydrogen sulfide (H2S), the third gasotransmitter together with NO and CO, is emerging as a regulator of inflammation. To test if it might offer therapeutic value in the treatment of osteoarthritis ...
Induced pluripotent stem cells for cartilage repair: current status and future perspectives
(AO Research Institute Davos, 2018-09-11)
[Abstract] The establishment of cartilage regenerative medicine is an important clinical issue, but the search for cell sources able to restore cartilage integrity proves to be challenging. Human mesenchymal stromal cells ...
Human amniotic membrane as an alternative source of stem cells for regenerative medicine
(Elsevier, 2011-02-19)
[Abstract] The human amniotic membrane (HAM) is a highly abundant and readily available tissue. This amniotic tissue has considerable advantageous characteristics to be considered as an attractive material in the field of ...
Intraarticular Administration Effect of Hydrogen Sulfide on an In Vivo Rat Model of Osteoarthritis
(MDPI, 2020-10-08)
[Abstract]
Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological ...
Molecular profile and cellular characterization of human bone marrow mesenchymal stem cells: donor influence on chondrogenesis
(Elsevier, 2010)
[Abstract] Background. The use of autologous or allogenic stem cells has recently been suggested as an alternative therapeutic approach for treatment of cartilage defects. Bone marrow mesenchymal stem cells (BM-MSCs) are ...
Potential use of the human amniotic membrane as a scaffold in human articular cartilage repair
(Springer, 2010-04-13)
[Abstract] The human amniotic membrane (HAM) is an abundant and readily obtained tissue that may be an important source of scaffold for transplanted chondrocytes in cartilage regeneration in vivo. To evaluate the potential ...
The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes–associated osteoarthritis
(American Society for Biochemistry and Molecular Biology, 2017-09-01)
[Asbtract] Epidemiological findings support the hypothesis that type 2 diabetes mellitus (T2DM) is a risk factor for osteoarthritis (OA). Moreover, OA cartilage from patients with T2DM exhibits a greater response to ...
Clinical profile, level of affection and therapeutic management of patients with osteoarthritis in primary care: the spanish multicenter study EVALÚA
(Elsevier, 2015-04-16)
[Abstract] Objective. To determine the clinical profile, degree of involvement and management in patients with knee, hip or hand osteoarthritis.
Methods. Observational study (health centres from 14 autonomous regions, n ...
Mitochondrial activity is modulated by TNFα and IL-1β in normal human chondrocyte cells
(Elsevier, 2006-05-05)
[Abstract] Objective. Pro-inflammatory cytokines play an important role in osteoarthritis (OA). In osteoarthritic cartilage, chondrocytes exhibit an alteration in mitochondrial activity. This study analyzes the effect of ...
Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro
(Elsevier, 2017-11-01)
[Abstract] Healthy cartilage maintenance relies on an equilibrium among the anabolic and catabolic processes in chondrocytes. With the onset of osteoarthritis (OA), increased interleukin (IL)-1β levels induce an inhibition ...