Mesenchymal stromal cells for articular cartilage repair: preclinical studies

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- Investigación (FCS) [1284]
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Mesenchymal stromal cells for articular cartilage repair: preclinical studiesAutor(es)
Data
2020-08-26Cita bibliográfica
Fernández-Pernas P, Barrachina L, Marquina M, Rodellar C, Arufe MC, Costa C. Mesenchymal stromal cells for articular cartilage repair: preclinical studies. Eur Cell Mater. 2020; 40:88-114
Resumo
[Abstract]
Rheumatic diseases such as osteoarthritis (OA) are a major social and economic burden because of the
population aging and the lack of curative solutions. An effective cell therapy may be the best treatment option
for OA and other cartilage diseases. However, the main cellular strategy used to repair articular cartilage, the
transplantation of autologous chondrocytes, is limited to a small number of patients with traumatic lesions. The
use of joint replacement after years of disease progression proves the great medical need in current practice.
Mesenchymal stromal/stem cells (MSCs) provide an alternative cell source for cartilage regeneration due
to numerous advantages, comprising relative ease to isolate and culture, chondrogenic capacity, and antiinflammatory effects. Initial clinical trials with MSCs have led to encouraging results, but many variables have
to be considered to attain true amelioration of disease or repair (type and status of cartilage disease, source
and conditions of cells, administration regime, combinatorial approaches). Particularly, allogeneic MSCs are
an advantageous cellular product. The animal models chosen for preclinical evaluation are also relevant for
successful translation into clinical practice. Considering the limitations in the field, rigorous comparative
and validating studies in well-established animal models (including large animals) are still needed to set up
the bases for additional clinical trials. The present review of studies performed in small and large animal
models should help clarify the applicability of MSC-based therapies for articular cartilage repair.
Palabras chave
Mesenchymal stromal cells
Mesenchymal stem cells
Cartilage repair
Osteoarthritis
Animal models
Immune modulation
Mesenchymal stem cells
Cartilage repair
Osteoarthritis
Animal models
Immune modulation
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Creative Commons Attribution 4.0 International License (CC-BY 4.0)
ISSN
1473-2262