Mostrar o rexistro simple do ítem
Mesenchymal stromal cells for articular cartilage repair: preclinical studies
dc.contributor.author | Fernández-Pernas, Pablo | |
dc.contributor.author | Barrachina, Laura | |
dc.contributor.author | Marquina, Maribel | |
dc.contributor.author | Rodellar, C. | |
dc.contributor.author | Arufe, M.C. | |
dc.contributor.author | Costa, Cristina | |
dc.date.accessioned | 2020-10-20T08:10:44Z | |
dc.date.available | 2020-10-20T08:10:44Z | |
dc.date.issued | 2020-08-26 | |
dc.identifier.citation | Fernández-Pernas P, Barrachina L, Marquina M, Rodellar C, Arufe MC, Costa C. Mesenchymal stromal cells for articular cartilage repair: preclinical studies. Eur Cell Mater. 2020; 40:88-114 | es_ES |
dc.identifier.issn | 1473-2262 | |
dc.identifier.uri | http://hdl.handle.net/2183/26467 | |
dc.description.abstract | [Abstract] Rheumatic diseases such as osteoarthritis (OA) are a major social and economic burden because of the population aging and the lack of curative solutions. An effective cell therapy may be the best treatment option for OA and other cartilage diseases. However, the main cellular strategy used to repair articular cartilage, the transplantation of autologous chondrocytes, is limited to a small number of patients with traumatic lesions. The use of joint replacement after years of disease progression proves the great medical need in current practice. Mesenchymal stromal/stem cells (MSCs) provide an alternative cell source for cartilage regeneration due to numerous advantages, comprising relative ease to isolate and culture, chondrogenic capacity, and antiinflammatory effects. Initial clinical trials with MSCs have led to encouraging results, but many variables have to be considered to attain true amelioration of disease or repair (type and status of cartilage disease, source and conditions of cells, administration regime, combinatorial approaches). Particularly, allogeneic MSCs are an advantageous cellular product. The animal models chosen for preclinical evaluation are also relevant for successful translation into clinical practice. Considering the limitations in the field, rigorous comparative and validating studies in well-established animal models (including large animals) are still needed to set up the bases for additional clinical trials. The present review of studies performed in small and large animal models should help clarify the applicability of MSC-based therapies for articular cartilage repair. | es_ES |
dc.description.sponsorship | This work was funded by Ministerio de Ciencia e Innovación - Instituto de Salud Carlos III (ISCiii) (PI11/02179 granted to CC and PI11/02799 granted to MCA), the SLT002/16/00445 grant to CC funded by the Department of Health of the Generalitat de Catalunya, Ministerio de Economía y Competitividad-ISCiii (PI15/00181 granted to CC), Ministerio de Industria, Economía y Competitividad (AGL2017-84411-P granted to CR), and co-funded by FEDER funds – a way to build Europe. IDIBELL benefits from the support of CERCA. P.F.-P. benefited from a two-month fellowship from CIBER-BBN-ISCiii. | |
dc.description.sponsorship | info:eu-repo/grantAgreement/MICINN/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI11%2F02179/ES/Combinación de terapias celulares para la reparación de lesiones de cartílago | |
dc.description.sponsorship | info:eu-repo/grantAgreement/MICINN/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI11%2F02799/ES/Combinación de terapias celulares para la reparación de lesiones de cartílago | |
dc.description.sponsorship | Generalitat de Catalunya; SLT002/16/00445 | |
dc.description.sponsorship | info:eu-repo/granAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI15%2F00181/ES/Desarrollo de nuevas estrategias para prevenir la degeneración estructural de las válvulas cardíacas bioprotésicas | |
dc.description.sponsorship | Ministerio de Industria, Economía y Competitividad (España); GL2017-84411-P | |
dc.language.iso | eng | es_ES |
dc.publisher | AO Research Institute Davos (ARI) | es_ES |
dc.relation.uri | https://doi.org/10.22203/eCM.v040a06 | es_ES |
dc.rights | Creative Commons Attribution 4.0 International License (CC-BY 4.0) | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Mesenchymal stromal cells | es_ES |
dc.subject | Mesenchymal stem cells | es_ES |
dc.subject | Cartilage repair | es_ES |
dc.subject | Osteoarthritis | es_ES |
dc.subject | Animal models | es_ES |
dc.subject | Immune modulation | es_ES |
dc.title | Mesenchymal stromal cells for articular cartilage repair: preclinical studies | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | European Cells and Materials | es_ES |
UDC.volume | 40 | es_ES |
UDC.startPage | 88 | es_ES |
UDC.endPage | 114 | es_ES |
Ficheiros no ítem
Este ítem aparece na(s) seguinte(s) colección(s)
-
GI-TCMR - Artigos [129]
-
INIBIC-TCMR - Artigos [102]