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Prevalence of Systemic Lupus Erythematosus in Spain: Higher than Previously Reported in Other Countries?
(Oxford, 2020-01-30)
[Abstract] Objectives: Prevalence of SLE varies among studies, being influenced by study design, geographical area and ethnicity. Data about the prevalence of SLE in Spain are scarce. In the EPISER2016 study, promoted by ...
Mitochondrial DNA in Osteoarthritis Disease
(Springer, 2020-09-25)
[Abstract]
Osteoarthritis (OA) is the most prevalent chronic joint disease, and we actually know that the activation of maladaptive responses to injury, including pro-inflammatory pathways, leads to the loss of normal ...
Efficacy, Safety and Cost-Effectiveness of Methotrexate, Adalimumab or Their Combination in Non-infectious Non-anterior Uveitis: A Protocol for a Multicentre, Randomised, Parallel Three Arms, Active-Controlled, Phase III Open Label With Blinded Outcome Assessment Study
(BMJ Publishing Group, 2022-03-22)
[Abstract]
Introduction: Non-infectious uveitis include a heterogeneous group of sight-threatening and incapacitating conditions. Their correct management sometimes requires the use of immunosuppressive drugs (ISDs), ...
Genetic biomarkers in osteoarthritis: a quick overview
(Faculty Opinions, 2021-11-10)
[Abstract] Osteoarthritis (OA) is a chronic musculoskeletal disease with a polygenic and heterogeneous nature. In addition, when clinical manifestations appear, the evolution of the disease is usually already irreversible. ...
Test–retest precision and longitudinal cartilage thickness loss in the IMI-APPROACH cohort
(Elsevier, 2022-11-03)
[Abstract] Objective. To investigate the test–retest precision and to report the longitudinal change in cartilage thickness, the percentage of knees with progression and the predictive value of the machine-learning-estimated ...
Analyses of the genetic polymorphisms rs3740199 and rs1871054 of the ADAM12 gene and the alleles at the rs2073508 loci of the TGFB1 gene and their contribution to susceptibility to primary knee osteoarthritis
(Mary Ann Liebert, 2020-06)
[Abstract] Aims: To analyze the association of polymorphisms in the ADAM12 (rs3740199 and rs1871054) and TGFB1 (rs2073508) genes with knee osteoarthritis (KOA) in a population from northern Mexico. Methods: A total of 296 ...
Pain assessment during eye examination for retinopathy of prematurity screening: skin conductance versus PIPP-R
(John Wiley & Sons, 2020-05)
[Abstract]
Aim: To assess changes in skin conductance during retinopathy of prematurity screening and to study the correlation between the skin conductance and a validated pain scale.
Methods: Prospective observational ...
GaitSmart motion analysis compared to commonly used function outcome measures in the IMI-APPROACH knee osteoarthritis cohort
(PLoS ONE, 2022-03-23)
[Abstract] Background: There are multiple measures for assessment of physical function in knee osteoarthritis (OA), but each has its strengths and limitations. The GaitSmart® system, which uses inertial measurement units ...
Longitudinal analysis of blood DNA methylation identifies mechanisms of response to tumor necrosis factor inhibitor therapy in rheumatoid arthritis
(Elsevier, 2022-05-13)
[Abstract] Background: Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease of the joints that has been associated with variation in the peripheral blood methylome. In this study, we aim to identify ...
Is osteoarthritis a mitochondrial disease?: what is the evidence
(Wolters Kluwer, 2022-01)
[Abstract] Propose of review: To summarize the evidence that suggests that osteoarthritis (OA) is a mitochondrial disease.
Recent findings: Mitochondrial dysfunction together with mtDNA damage could contribute to cartilage ...