Analyses of the genetic polymorphisms rs3740199 and rs1871054 of the ADAM12 gene and the alleles at the rs2073508 loci of the TGFB1 gene and their contribution to susceptibility to primary knee osteoarthritis
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Analyses of the genetic polymorphisms rs3740199 and rs1871054 of the ADAM12 gene and the alleles at the rs2073508 loci of the TGFB1 gene and their contribution to susceptibility to primary knee osteoarthritisAutor(es)
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2020-06Cita bibliográfica
Aguilar Muñiz LS, González Galarza FF, Arguello Astorga R, Prieto Hinojosa AI, Hernández Terán F, Méndez Hernández A, Espino Silva PK, Blanco García FJ, Arellano Pérez Vertti RD. Analyses of the genetic polymorphisms rs3740199 and rs1871054 of the ADAM12 gene and the alleles at the rs2073508 loci of the TGFB1 gene and their contribution to susceptibility to primary knee osteoarthritis. Genet Test Mol Biomarkers. 2020 Jun;24(6):375-380.
Resumo
[Abstract] Aims: To analyze the association of polymorphisms in the ADAM12 (rs3740199 and rs1871054) and TGFB1 (rs2073508) genes with knee osteoarthritis (KOA) in a population from northern Mexico. Methods: A total of 296 individuals were included in the study. Primary KOA was confirmed according to the criteria established by the American College of Rheumatology. A real-time PCR-based DNA genotyping method was used to evaluate the rs3740199, rs1871054, and rs2073508 polymorphisms in 132 cases and 164 controls. Results: Our results demonstrate that the ADAM12 rs3740199 polymorphism was significantly associated with primary KOA under the recessive model (p = 0.036). However, after performing a multinomial logistic regression model, no significant association was found (p = 0.722). Furthermore, no associations for the rs1871054 and rs2073508 polymorphisms were observed in this study. Conclusion: These findings suggest that polymorphisms within the ADAM12 and TGFB1 genes may not have a significant influence on primary KOA susceptibility in the Mexican Mestizo population; however, inclusion of other ethnic groups and a larger sample size are needed to more fully analyze the role of these polymorphisms with KOA risk.
Palabras chave
ADAM12
TGFB1
Knee osteoarthritis
Polymorphism
TGFB1
Knee osteoarthritis
Polymorphism
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Dereitos
This is the accepted version of the article which has now been formally published in final form at Genetic Testing and Molecular Biomarkers. This original submission version of the article may be used for non-commercial purposes in accordance with the Mary Ann Liebert, Inc., publishers’ self-archiving terms and conditions.
ISSN
1945-0265