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Integrative Metabolic Pathway Analysis Reveals Novel Therapeutic Targets in Osteoarthritis
(American Society for Biochemistry and Molecular Biology (ASBMB), 2020-01-24)
[Abstract] In osteoarthritis (OA), impairment of cartilage regeneration can be related to a defective chondrogenic differentiation of mesenchymal stromal cells (MSCs). Therefore, understanding the proteomic- and ...
Characterisation of Long-Term Cancer Survivors and Application of Statistical Cure Models: A Protocol for an Observational Follow-up Study in Patients With Colorectal Cancer
(BioMed Central, 2020-11-17)
[Abstract] Background: Improved colorectal cancer (CRC) survival rates have been reported over the last years, with more than half of these patients surviving more than 5 years after the initial diagnosis. Better understanding ...
Expert recommendations on the interleukin 6 blockade in patients with rheumatoid arthritis
(Elsevier, 2020-07)
[Abstract] Objective: To draft recommendations on interleukin 6 (IL-6) blockade in rheumatoid arthritis (RA), based on best evidence and experience.
Methods: A group of 10 experts on IL-6 blockade in RA was selected. ...
Analyses of the genetic polymorphisms rs3740199 and rs1871054 of the ADAM12 gene and the alleles at the rs2073508 loci of the TGFB1 gene and their contribution to susceptibility to primary knee osteoarthritis
(Mary Ann Liebert, 2020-06)
[Abstract] Aims: To analyze the association of polymorphisms in the ADAM12 (rs3740199 and rs1871054) and TGFB1 (rs2073508) genes with knee osteoarthritis (KOA) in a population from northern Mexico. Methods: A total of 296 ...
Immortalizing mesenchymal stromal cells from aged donors while keeping their essential features
(Hindawi, 2020-06-16)
[Abstract] Human bone marrow-derived mesenchymal stromal cells (MSCs) obtained from aged patients are prone to senesce and diminish their differentiation potential, therefore limiting their usefulness for osteochondral ...
Versatility of induced Pluripotent Stem Cells (iPSCs) for improving the knowledge on musculoskeletal diseases
(MDPI, 2020-08-25)
[Abstract]
Induced pluripotent stem cells (iPSCs) represent an unlimited source of pluripotent cells
capable of di erentiating into any cell type of the body. Several studies have demonstrated the valuable
use of iPSCs ...
Generation and Characterization of Human Induced Pluripotent Stem Cells (iPSCs) From Hand Osteoarthritis Patient-Derived Fibroblasts
(Nature Research, 2020-03-06)
[Abstract]
Knowledge and research results about hand osteoarthritis (hOA) are limited due to the lack of samples and animal models of the disease. Here, we report the generation of two induced pluripotent stem cell ...
Generation of a human control iPS cell line (ESi080‐A) from a donor with no rheumatic diseases
(Elsevier, 2020-03)
[Abstract]
Here, we report the establishment of the human iPS cell line N1-FiPS4F#7 generated from skin cells of a patient with no rheumatic diseases, thus obtaining an appropriate control iPS cell line for researchers ...
Pain assessment during eye examination for retinopathy of prematurity screening: skin conductance versus PIPP-R
(John Wiley & Sons, 2020-05)
[Abstract]
Aim: To assess changes in skin conductance during retinopathy of prematurity screening and to study the correlation between the skin conductance and a validated pain scale.
Methods: Prospective observational ...
Intraarticular administration effect of hydrogen sulfide on an in vivo rat model of osteoarthritis
(MDPI, 2020-10-08)
[Abstract]
Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological ...