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Influence of mesenchymal stem cell-derived extracellular vesicles in vitro and their tole in ageing
(Springer Nature, 2020-01-03)
[Abstract]
Introduction: This study assessed whether mesenchymal stem cell (MSC)-derived extracellular vesicles influenced
ageing and pluripotency markers in cell cultures where they are added.
Methods: MSC-derived ...
Medicina termal en enfermedades reumáticas: evidencia científica y actualidad de los mecanismos de acción
(Sociedad Española de Hidrología Médica, 2020)
[Resumen] La patología músculo-esquelética es la responsable en la actualidad de la mayoría de las prescripciones de la curas termales en diversos países. La eficacia de la balneoterapia en reumatología, ha sido confirmada ...
Mesenchymal stromal cells for articular cartilage repair: preclinical studies
(AO Research Institute Davos (ARI), 2020-08-26)
[Abstract]
Rheumatic diseases such as osteoarthritis (OA) are a major social and economic burden because of the
population aging and the lack of curative solutions. An effective cell therapy may be the best treatment ...
In vitro study of the therapeutic potential of brown crude fucoidans in osteoarthritis treatment
(MDPI, 2022-11-17)
[Abstract] Osteoarthritis, one of the most common joint degenerative pathologies, still has no cure, and current treatments, such as nonsteroidal anti-inflammatory drugs, can cause serious adverse effects when taken for a ...
Therapeutic characteristics of Galician mineral and thermal waters (NW-Spain) ascribed to their local/regional geological setting
(Springer, 2017-03-06)
[Abstract]
Galicia is located in the NW corner of the Iberian Peninsula (Spain). From a geological point of view, the
territory belongs to the Hercynian chain and, more specifically, to a large outcrop dominated by igneous ...
Effect of aging on behaviour of mesenchymal stem cells
(Baishideng Publishing Group Inc., 2019-06-26)
[Abstract] Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult ...
15-Deoxy-Δ-12, 14-prostaglandin J2 acts cooperatively with prednisolone to reduce TGF-β-induced pro-fibrotic pathways in human osteoarthritis fibroblasts
(Elsevier, 2019-03-29)
[Abstract] Abstract
Background/aims: Synovial fibrosis is a pathological process that is observed in several musculoskeletal disorders and characterized by the excessive deposition of extracellular matrix, as well as cell ...
FASN activity is important for the initial stages of the induction of senescence
(Springer Nature, 2019-04-08)
[Abstract] Senescent cells accumulate in several tissues during ageing and contribute to several pathological processes such as ageing and cancer. Senescence induction is a complex process not well defined yet and is ...
Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence via the interferon protein IFITM3
(Cell Press, 2019-06-25)
[Abstract] Senescence is a cellular phenotype present in health and disease, characterized by a stable cell-cycle arrest and an inflammatory response called senescence-associated secretory phenotype (SASP). The SASP is ...
Small extracellular vesicles have GST activity and ameliorate senescence-related tissue damage
(Elsevier, 2020-07-07)
[Abstract]
Aging is a process of cellular and tissue dysfunction characterized by different hallmarks, including cellular senescence. However, there is proof that certain features of aging and senescence can be ameliorated. ...