Listar GI-TCMR - Artigos por título
Mostrando ítems 87-106 de 129
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NF-κB/IKK Activation by Small Extracellular Vesicles Within the SASP
(Wiley, 2021-06-29)[Abstract] Cellular senescence plays an important role in different biological and pathological conditions. Senescent cells communicate with their microenvironment through a plethora of soluble factors, metalloproteases ... -
Niosomes-Based Gene Delivery Systems for Effective Transfection of Human Mesenchymal Stem Cells
(Elsevier, 2021-07-11)[Abstract] Gene transfer to mesenchymal stem cells (MSCs) has arisen as a powerful approach to increase the therapeutic potential of this effective cell population. Over recent years, niosomes have emerged as self-assembled ... -
Notch signalling in cancer stem cells
(Springer, 2009)[Abstract] A new theory about the development of solid tumours is emerging from the idea that solid tumours, like normal adult tissues, contain stem cells (called cancer stem cells) and arise from them. Genetic mutations ... -
Origin of renal cell carcinomas
(Springer, 2008-11-28)[Abstract] Cancer is a heritable disorder of somatic cells: environment and heredity are both important in the carcinogenic process. The primal force is the “two hits” of Knudson’s hypothesis, which has proved true for ... -
Ovine mesenchymal stromal cells: morphologic, phenotypic and functional characterization for osteochondral tissue engineering
(PLoS ONE, 2017-01-31)[Abstract] Introduction. Knowledge of ovine mesenchymal stromal cells (oMSCs) is currently expanding. Tissue engineering combining scaffolding with oMSCs provides promising therapies for the treatment of osteochondral ... -
PEO-PPO-PEO tri-block copolymers for gene delivery applications in human regenerative medicine: an overview
(MDPI, 2018-03-08)[Abstract] Lineal (poloxamers or Pluronic®) or X-shaped (poloxamines or Tetronic®) amphiphilic tri-block copolymers of poly(ethylene oxide) and poly(propylene oxide) (PEO-PPO-PEO) have been broadly explored for controlled ... -
Perceptions of patients with rheumatic diseases on the impact on daily life and satisfaction with their medications: RHEU-LIFE, a survey to patients treated with subcutaneous biological products
(Dovepress, 2017-07-19)[Abstract] Objective: The aim of this study was to explore perceptions of patients with rheumatic diseases treated with subcutaneous (SC) biological drugs on the impact on daily life and satisfaction with current therapy, ... -
Potential use of the human amniotic membrane as a scaffold in human articular cartilage repair
(Springer, 2010-04-13)[Abstract] The human amniotic membrane (HAM) is an abundant and readily obtained tissue that may be an important source of scaffold for transplanted chondrocytes in cartilage regeneration in vivo. To evaluate the potential ... -
Prostate cancer and Hedgehog signalling pathway
(Springer, 2007-08-02)[Abstract] The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, ... -
Proteome Analysis During Chondrocyte Differentiation in a New Chondrogenesis Model Using Human Umbilical Cord Stroma Mesenchymal Stem Cells
(American Society for Biochemistry and Molecular Biology, 2011-10-17)[Abstract] Umbilical cord stroma mesenchymal stem cells were differentiated toward chondrocyte-like cells using a new in vitro model that consists of the random formation of spheroids in a medium supplemented with fetal ... -
Proteomic Applications in the Study of Human Mesenchymal Stem Cells
(Multidisciplinary Digital Publishing Institute, 2014-02-07)Mesenchymal stem cells (MSCs) are undifferentiated cells with an unlimited capacity for self-renewal and able to differentiate towards specific lineages under appropriate conditions. MSCs are, a priori, a good target for ... -
Quantification of cells expressing mesenchymal stem cell markers in healthy and osteoarthritic synovial membranes
(Journal of Rheumatology Publishing Company, 2010-11-15)[Abstract] Objective. To quantify cells expressing mesenchymal stem cell (MSC) markers in synovial mem- branes from human osteoarthritic (OA) and healthy joints. Methods. Synovial membranes from OA and healthy joints were ... -
rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells
(MDPI, 2020-04-28)[Abstract] Scaffold-assisted gene therapy is a highly promising tool to treat articular cartilage lesions upon direct delivery of chondrogenic candidate sequences. The goal of this study was to examine the feasibility ... -
Real-world effectiveness and safety of SDZ ETN, an etanercept biosimilar, in patients with rheumatic diseases: final results from multi-country COMPACT study
(Springer Nature, 2023-11-11)[Abstract] Introduction: COMPACT, a non-interventional study, evaluated the persistence, effectiveness, safety and patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA), axial-spondyloarthritis (axSpA) ... -
Regulation of Angiogenesis Discriminates Tissue Resident MSCs from Effective and Defective Osteogenic Environments
(MDPI, 2020-05-28)[Abstract] Background: The biological mechanisms that contribute to atrophic long bone non-union are poorly understood. Multipotential mesenchymal stromal cells (MSCs) are key contributors to bone formation and are ... -
Relevance of the extraction stage on the anti-inflammatory action of fucoidans
(MDPI, 2023-03-01)[Abstract] The anti-inflammatory action of fucoidans is well known, based on both in vitro and some in vivo studies. The other biological properties of these compounds, their lack of toxicity, and the possibility of obtaining ... -
Remodeling of human osteochondral defects via rAAV-mediated co-overexpression of TGF-β and IGF-I from implanted human bone marrow-derived mesenchymal stromal cells
(MDPI, 2019-08-28)[Abstract] The application of chondrogenic gene sequences to human bone marrow-derived mesenchymal stromal cells (hMSCs) is an attractive strategy to activate the reparative activities of these cells as a means to enhance ... -
Risks factors of mechanical ventilation in acute traumatic cervical spinal cord injured patients
(Nature, 2017-10-23)[Abstract] Study design. Descriptive retrospective study. Objectives. To analyze risk factors associated with mechanical ventilation (MV) in cases of acute traumatic Cervical Spinal Cord Injury (tCSCI). Setting. Unidad ... -
Scaffold-Mediated Gene Delivery for Osteochondral Repair
(MDPI, 2020-09-29)[Abstract] Osteochondral defects involve both the articular cartilage and the underlying subchondral bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery of gene vectors has ... -
Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence via the interferon protein IFITM3
(Cell Press, 2019-06-25)[Abstract] Senescence is a cellular phenotype present in health and disease, characterized by a stable cell-cycle arrest and an inflammatory response called senescence-associated secretory phenotype (SASP). The SASP is ...
