Formononetin, a beer polyphenol with catabolic effects on chondrocytes
Ver/ abrir
Use este enlace para citar
http://hdl.handle.net/2183/35105
A non ser que se indique outra cousa, a licenza do ítem descríbese como Creative Commons Attribution 4.0 International Licence (CC-BY 4.0)
Coleccións
- GI-TCMR - Artigos [131]
Metadatos
Mostrar o rexistro completo do ítemTítulo
Formononetin, a beer polyphenol with catabolic effects on chondrocytesAutor(es)
Data
2023-06-29Cita bibliográfica
Guillán-Fresco M, Franco-Trepat E, Alonso-Pérez A, Jorge-Mora A, López-López V, Pazos-Pérez A, Piñeiro-Ramil M, Gómez R. Formononetin, a beer polyphenol with catabolic effects on chondrocytes. Nutrients. 2023 Jun 29;15(13):2959.
Resumo
[Abstract] Beer consumption has been identified as a risk factor for osteoarthritis (OA), a rheumatic disease characterised by cartilage degradation, joint inflammation, and eventual joint failure. One of the main isoflavonoids in beer is formononetin (FNT), an estrogenic compound also found in multiple plants and herbs. In this study, we aimed to investigate the effect of FNT on chondrocyte viability, inflammation, and metabolism. Cells were treated with FNT with or without IL-1β for 48 h and during 7 days of differentiation. Cell viability was determined via MTT assay. Nitrite accumulation was determined by Griess reaction. The expression of genes involved in inflammation and metabolism was determined by RT-PCR. The results revealed that a low concentration of FNT had no deleterious effect on cell viability and decreased the expression of inflammation-related genes. However, our results suggest that FNT overexposure negatively impacts on chondrocytes by promoting catabolic responses. Finally, these effects were not mediated by estrogen receptors (ERs) or aryl hydrocarbon receptor (AhR). In conclusion, factors that favour FNT accumulation, such as long exposure times or metabolic disorders, can promote chondrocyte catabolism. These data may partially explain why beer consumption increases the risk of OA.
Palabras chave
Growth plate
Osteoarthritis
Phytoestrogens
Osteoarthritis
Phytoestrogens
Versión do editor
Dereitos
Creative Commons Attribution 4.0 International Licence (CC-BY 4.0)
ISSN
2072-6643