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dc.contributor.authorGuillán-Fresco, María
dc.contributor.authorFranco-Trepat, Eloi
dc.contributor.authorAlonso-Pérez, Ana
dc.contributor.authorJorge-Mora, Alberto
dc.contributor.authorLópez-López, Verónica
dc.contributor.authorPazos-Pérez, Andrés
dc.contributor.authorPiñeiro-Ramil, María
dc.contributor.authorGómez, Rodolfo
dc.date.accessioned2024-01-24T10:50:08Z
dc.date.available2024-01-24T10:50:08Z
dc.date.issued2023-06-29
dc.identifier.citationGuillán-Fresco M, Franco-Trepat E, Alonso-Pérez A, Jorge-Mora A, López-López V, Pazos-Pérez A, Piñeiro-Ramil M, Gómez R. Formononetin, a beer polyphenol with catabolic effects on chondrocytes. Nutrients. 2023 Jun 29;15(13):2959.es_ES
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/2183/35105
dc.description.abstract[Abstract] Beer consumption has been identified as a risk factor for osteoarthritis (OA), a rheumatic disease characterised by cartilage degradation, joint inflammation, and eventual joint failure. One of the main isoflavonoids in beer is formononetin (FNT), an estrogenic compound also found in multiple plants and herbs. In this study, we aimed to investigate the effect of FNT on chondrocyte viability, inflammation, and metabolism. Cells were treated with FNT with or without IL-1β for 48 h and during 7 days of differentiation. Cell viability was determined via MTT assay. Nitrite accumulation was determined by Griess reaction. The expression of genes involved in inflammation and metabolism was determined by RT-PCR. The results revealed that a low concentration of FNT had no deleterious effect on cell viability and decreased the expression of inflammation-related genes. However, our results suggest that FNT overexposure negatively impacts on chondrocytes by promoting catabolic responses. Finally, these effects were not mediated by estrogen receptors (ERs) or aryl hydrocarbon receptor (AhR). In conclusion, factors that favour FNT accumulation, such as long exposure times or metabolic disorders, can promote chondrocyte catabolism. These data may partially explain why beer consumption increases the risk of OA.es_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/ISCIII/Programa Estatal para Impulsar la Investigación Científico-Técnica y su Transferencia/PI22%2F00407/Identificación de biomarcadores y factores implicados en la osificación heterotópica articular y su relación con las respuestas inmunes innatases_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI19%2F01446/CARACTERIZACION CELULAR CIRCULANTE E INHIBICION FARMACOLOGICA DEL CRECIMIENTO ANOMALO DEL HUESO ASOCIADO A LA OSIFICACION HETEROTOPICAes_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI16%2F01870/Estudio de los factores de transcripción asociados a los cambios en la metilación del ADN durante la osteoblastogénesis y su papel en la diferenciación del osteoblastoes_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/CP15%2F00007es_ES
dc.description.sponsorshipThis work was funded by the Instituto de Salud Carlos III (ISCIII) through the projects [grant numbers PI22/00407, PT20/00009, FI20/00210, CM20/00186, RD21/0002/0025, PI19/01446, PI16/01870, CPII20/00026, CP15/00007] and co-funded by the European Union via “Fondo de Investigación Sanitaria” from Fondo Europeo de Desarrollo Regional (FEDER); the Spanish Ministry of Science via FECYT [grant number PRECIPITA PR250], Mutua Madrileña Foundation [grant numbers MMA 2018 & MMA 2020], and Ministry of Universities [grant numbers FPU17/01706 and UDC Margarita Salas RSU.UDC.MS06, funded by the European Union through NextGenerationEU]. This publication is part of the ENDOTARGET project, that has received funding from the European Union’s Horizon Europe research and innovation programme, with project number 101095084. Support was also associated to personnel: E.F.-T. [MMA 2018], M.G.-F. [FPU17/01706], A.A.-P. [IDIS 2019], M.L.-F. [FI20/00210], A.P.-P. [MMA 2020], A.C.-G. [Rio Hortega CM20/00186], A.J.-M. [SERGAS no grant number], S.B.B. [IDIS no grant number], O.G. [SERGAS no grant number], R.G. [ISCIII and SERGAS via Miguel Servet II program CPII20/00026], V.L-L. [PT20/00009], and M.P.-R. [UDC Margarita Salas RSU.UDC.MS06].es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.urihttps://doi.org/10.3390/nu15132959es_ES
dc.rightsCreative Commons Attribution 4.0 International Licence (CC-BY 4.0)es_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGrowth platees_ES
dc.subjectOsteoarthritises_ES
dc.subjectPhytoestrogenses_ES
dc.titleFormononetin, a beer polyphenol with catabolic effects on chondrocyteses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleNutrientses_ES
UDC.volume15es_ES
UDC.issue13es_ES
UDC.startPage2959es_ES


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