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Formononetin, a beer polyphenol with catabolic effects on chondrocytes
dc.contributor.author | Guillán-Fresco, María | |
dc.contributor.author | Franco-Trepat, Eloi | |
dc.contributor.author | Alonso-Pérez, Ana | |
dc.contributor.author | Jorge-Mora, Alberto | |
dc.contributor.author | López-López, Verónica | |
dc.contributor.author | Pazos-Pérez, Andrés | |
dc.contributor.author | Piñeiro-Ramil, María | |
dc.contributor.author | Gómez, Rodolfo | |
dc.date.accessioned | 2024-01-24T10:50:08Z | |
dc.date.available | 2024-01-24T10:50:08Z | |
dc.date.issued | 2023-06-29 | |
dc.identifier.citation | Guillán-Fresco M, Franco-Trepat E, Alonso-Pérez A, Jorge-Mora A, López-López V, Pazos-Pérez A, Piñeiro-Ramil M, Gómez R. Formononetin, a beer polyphenol with catabolic effects on chondrocytes. Nutrients. 2023 Jun 29;15(13):2959. | es_ES |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | http://hdl.handle.net/2183/35105 | |
dc.description.abstract | [Abstract] Beer consumption has been identified as a risk factor for osteoarthritis (OA), a rheumatic disease characterised by cartilage degradation, joint inflammation, and eventual joint failure. One of the main isoflavonoids in beer is formononetin (FNT), an estrogenic compound also found in multiple plants and herbs. In this study, we aimed to investigate the effect of FNT on chondrocyte viability, inflammation, and metabolism. Cells were treated with FNT with or without IL-1β for 48 h and during 7 days of differentiation. Cell viability was determined via MTT assay. Nitrite accumulation was determined by Griess reaction. The expression of genes involved in inflammation and metabolism was determined by RT-PCR. The results revealed that a low concentration of FNT had no deleterious effect on cell viability and decreased the expression of inflammation-related genes. However, our results suggest that FNT overexposure negatively impacts on chondrocytes by promoting catabolic responses. Finally, these effects were not mediated by estrogen receptors (ERs) or aryl hydrocarbon receptor (AhR). In conclusion, factors that favour FNT accumulation, such as long exposure times or metabolic disorders, can promote chondrocyte catabolism. These data may partially explain why beer consumption increases the risk of OA. | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal para Impulsar la Investigación Científico-Técnica y su Transferencia/PI22%2F00407/Identificación de biomarcadores y factores implicados en la osificación heterotópica articular y su relación con las respuestas inmunes innatas | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI19%2F01446/CARACTERIZACION CELULAR CIRCULANTE E INHIBICION FARMACOLOGICA DEL CRECIMIENTO ANOMALO DEL HUESO ASOCIADO A LA OSIFICACION HETEROTOPICA | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI16%2F01870/Estudio de los factores de transcripción asociados a los cambios en la metilación del ADN durante la osteoblastogénesis y su papel en la diferenciación del osteoblasto | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/CP15%2F00007 | es_ES |
dc.description.sponsorship | This work was funded by the Instituto de Salud Carlos III (ISCIII) through the projects [grant numbers PI22/00407, PT20/00009, FI20/00210, CM20/00186, RD21/0002/0025, PI19/01446, PI16/01870, CPII20/00026, CP15/00007] and co-funded by the European Union via “Fondo de Investigación Sanitaria” from Fondo Europeo de Desarrollo Regional (FEDER); the Spanish Ministry of Science via FECYT [grant number PRECIPITA PR250], Mutua Madrileña Foundation [grant numbers MMA 2018 & MMA 2020], and Ministry of Universities [grant numbers FPU17/01706 and UDC Margarita Salas RSU.UDC.MS06, funded by the European Union through NextGenerationEU]. This publication is part of the ENDOTARGET project, that has received funding from the European Union’s Horizon Europe research and innovation programme, with project number 101095084. Support was also associated to personnel: E.F.-T. [MMA 2018], M.G.-F. [FPU17/01706], A.A.-P. [IDIS 2019], M.L.-F. [FI20/00210], A.P.-P. [MMA 2020], A.C.-G. [Rio Hortega CM20/00186], A.J.-M. [SERGAS no grant number], S.B.B. [IDIS no grant number], O.G. [SERGAS no grant number], R.G. [ISCIII and SERGAS via Miguel Servet II program CPII20/00026], V.L-L. [PT20/00009], and M.P.-R. [UDC Margarita Salas RSU.UDC.MS06]. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation.uri | https://doi.org/10.3390/nu15132959 | es_ES |
dc.rights | Creative Commons Attribution 4.0 International Licence (CC-BY 4.0) | es_ES |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Growth plate | es_ES |
dc.subject | Osteoarthritis | es_ES |
dc.subject | Phytoestrogens | es_ES |
dc.title | Formononetin, a beer polyphenol with catabolic effects on chondrocytes | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Nutrients | es_ES |
UDC.volume | 15 | es_ES |
UDC.issue | 13 | es_ES |
UDC.startPage | 2959 | es_ES |
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