Mostrar o rexistro simple do ítem
Is osteoarthritis a mitochondrial disease?: what is the evidence
dc.contributor.author | Fernández-Moreno, Mercedes | |
dc.contributor.author | Rego-Pérez, Ignacio | |
dc.contributor.author | Blanco García, Francico J | |
dc.date.accessioned | 2023-12-13T10:27:53Z | |
dc.date.available | 2023-12-13T10:27:53Z | |
dc.date.issued | 2022-01 | |
dc.identifier.citation | Fernández-Moreno M, Rego-Pérez I, Blanco FJ. Is osteoarthritis a mitochondrial disease?: what is the evidence. Curr Opin Rheumatol. 2022 Jan 1;34(1):46-53. | es_ES |
dc.identifier.issn | 1040-8711 | |
dc.identifier.uri | http://hdl.handle.net/2183/34474 | |
dc.description | Final peer-reviewed manuscript | es_ES |
dc.description.abstract | [Abstract] Propose of review: To summarize the evidence that suggests that osteoarthritis (OA) is a mitochondrial disease. Recent findings: Mitochondrial dysfunction together with mtDNA damage could contribute to cartilage degradation via several processes such as: (1) increased apoptosis; (2) decreased autophagy; (3) enhanced inflammatory response; (4) telomere shortening and increased senescence chondrocytes; (5) decreased mitochondrial biogenesis and mitophagy; (6) increased cartilage catabolism; (7) increased mitochondrial fusion leading to further reactive oxygen species production; and (8) impaired metabolic flexibility. Summary: Mitochondria play an important role in some events involved in the pathogenesis of OA, such as energy production, the generation of reactive oxygen and nitrogen species, apoptosis, authophagy, senescence and inflammation. The regulation of these processes in the cartilage is at least partially controlled by retrograde regulation from mitochondria and mitochondrial genetic variation. Retrograde regulation through mitochondrial haplogroups exerts a signaling control over the nuclear epigenome, which leads to the modulation of nuclear genes, cellular functions and development of OA. All these data suggest that OA could be considered a mitochondrial disease as well as other complex chronic disease as cancer, cardiovascular and neurologic diseases. | es_ES |
dc.description.sponsorship | This work is supported by grants from Fondo de Investigación Sanitaria (PI17/00210, PI20/00614, PI19/ 01206, and RETIC-RIER-RD16/0012/0002) integrated in the National Plan for Scientific Program, Development and Technological Innovation 2013–2016 and funded by the ISCIII-General Subdirection of Assessment and Promotion of Research- European Regional Development Fund (FEDER) ‘A way of making Europe’. The Biomedical Research Networking Center (CIBER) is an initiative from Instituto de Salud Carlos III (ISCIII). | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI17%2F00210/ES/IDENTIFICACION DE MARCADORES GENETICOS MITOCONDRIALES DE PROGRESION RAPIDA DE ARTROSIS DE RODILLA MEDIANTE TECNICAS DE SECUENCIACION MASIVA. | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI20%2F00614/ES/IDENTIFICACION DE MUTACIONES DE ADNMT ESPECIFICAS DE ARTROSIS MEDIANTE SECUENCIACION MASIVA PARA VALORAR SU IMPACTO COMO FUTURAS DIANAS TERAPEUTICAS Y EN EL DIGANOSTICO DE FENOTIPOS | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI19%2F01206/ES/VALIDACION CLINICA DE NUEVOS BIOMARCADORES PREDICTIVOS DE DIAGNOSTICO Y PRONOSTICO EN ARTROSIS: EL PROYECTO HPP | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/RD16%2F0012%2F0002/ES/Red de Investigación en Inflamación y Enfermedades Reumáticas (RIER) | |
dc.language.iso | eng | es_ES |
dc.publisher | Wolters Kluwer | es_ES |
dc.relation.uri | https://doi.org/10.1097/bor.0000000000000855 | es_ES |
dc.subject | Apoptosis | es_ES |
dc.subject | Cartilage | es_ES |
dc.subject | Mitochondria | es_ES |
dc.subject | mtDNA | es_ES |
dc.subject | Osteoarthritis | es_ES |
dc.title | Is osteoarthritis a mitochondrial disease?: what is the evidence | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Current Opinion in Rheumatology | es_ES |
UDC.volume | 34 | es_ES |
UDC.issue | 1 | es_ES |
UDC.startPage | 46 | es_ES |
UDC.endPage | 53 | es_ES |
Ficheiros no ítem
Este ítem aparece na(s) seguinte(s) colección(s)
-
INIBIC- REUMA - Artigos [184]