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Action mechanisms of small extracellular vesicles in inflammaging
dc.contributor.author | Mato Basalo, Rocío | |
dc.contributor.author | Lucio-Gallego, Sergio | |
dc.contributor.author | Alarcón-Veleiro, Carmen | |
dc.contributor.author | Sacristán-Santos, Marta | |
dc.contributor.author | Miranda Quintana, María del Pilar | |
dc.contributor.author | Morente López, Miriam | |
dc.contributor.author | De-Toro, Javier | |
dc.contributor.author | Silva-Fernández, Lucía | |
dc.contributor.author | González-Rodríguez, Alba | |
dc.contributor.author | Arufe, M.C. | |
dc.contributor.author | Fafián Labora, Juan Antonio | |
dc.date.accessioned | 2022-05-11T11:53:05Z | |
dc.date.available | 2022-05-11T11:53:05Z | |
dc.date.issued | 2022-04-06 | |
dc.identifier.citation | Mato-Basalo R, Lucio-Gallego S, Alarcón-Veleiro C, Sacristán-Santos M, Quintana MDPM, Morente-López M, de Toro FJ, Silva-Fernández L, González-Rodríguez A, Arufe MC, Labora JAF. Action mechanisms of small extracellular vesicles in inflammaging. Life (Basel). 2022 Apr 6;12(4):546. | es_ES |
dc.identifier.issn | 2075-1729 | |
dc.identifier.uri | http://hdl.handle.net/2183/30642 | |
dc.description | This article belongs to the Special Issue Extracellular Vesicles Research in Inflamm-Aging | es_ES |
dc.description.abstract | [Abstract] The accumulation process of proinflammatory components in the body due to aging influences intercellular communication and is known as inflammaging. This biological mechanism relates the development of inflammation to the aging process. Recently, it has been reported that small extracellular vesicles (sEVs) are mediators in the transmission of paracrine senescence involved in inflammatory aging. For this reason, their components, as well as mechanisms of action of sEVs, are relevant to develop a new therapy called senodrugs (senolytics and senomorphic) that regulates the intercellular communication of inflammaging. In this review, we include the most recent and relevant studies on the role of sEVs in the inflammatory aging process and in age-related diseases such as cancer and type 2 diabetes. | es_ES |
dc.description.sponsorship | J.F.L. was funded by Xunta de Galicia, Grant Number ED481D-2021-020. M.C.A. received a grant from the Spanish National Health Institute Carlos III (PI20/00497) | |
dc.description.sponsorship | Xunta de Galicia; ED481D-2021-020 | |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI20%2F00497/ES/TERAPIA CELULAR CON MICRO ARN Y VESICULAS EXTRACELULARES PARA EL TRATAMIENTO DE LA INFLAMACION CRONICA EN UN MODELO DE OA. (TERAPIA LIBRE DE CELULAS) | |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation.uri | https://doi.org/10.3390/life12040546 | es_ES |
dc.rights | Creative Commons Attribution 4.0 International License (CC-BY 4.0) | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Cellular senescence | es_ES |
dc.subject | Inflammaging | es_ES |
dc.subject | sEVs | es_ES |
dc.subject | Senomorphics | es_ES |
dc.title | Action mechanisms of small extracellular vesicles in inflammaging | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Life | es_ES |
UDC.volume | 12 | es_ES |
UDC.issue | 4 | es_ES |
UDC.startPage | 546 | es_ES |
dc.identifier.doi | 10.3390/life12040546 |
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