Action Mechanisms of Small Extracellular Vesicles in Inflammaging [Review]
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Action Mechanisms of Small Extracellular Vesicles in Inflammaging [Review]Author(s)
Date
2022-04-06Citation
Mato-Basalo, R.; Lucio-Gallego, S.; Alarcón-Veleiro, C.; Sacristán-Santos, M.; Quintana, M.d.P.M.; Morente-López, M.; de Toro, F.J.; Silva-Fernández, L.; González-Rodríguez, A.; Arufe, M.C.; Labora, J.A.F. Action Mechanisms of Small Extracellular Vesicles in Inflammaging. Life 2022, 12, 546. https://doi.org/10.3390/life12040546
Abstract
[Abstract] The accumulation process of proinflammatory components in the body due to aging influences intercellular communication and is known as inflammaging. This biological mechanism relates the development of inflammation to the aging process. Recently, it has been reported that small extracellular vesicles (sEVs) are mediators in the transmission of paracrine senescence involved in inflammatory aging. For this reason, their components, as well as mechanisms of action of sEVs, are relevant to develop a new therapy called senodrugs (senolytics and senomorphic) that regulates the intercellular communication of inflammaging. In this review, we include the most recent and relevant studies on the role of sEVs in the inflammatory aging process and in age-related diseases such as cancer and type 2 diabetes.
Keywords
Cellular senescence
Inflammaging
sEVs
Senomorphics
Inflammaging
sEVs
Senomorphics
Description
This article belongs to the Special Issue Extracellular Vesicles Research in Inflamm-Aging
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Rights
Atribución 4.0 Internacional
ISSN
2075-1729