Listar GI- NANOSELF4BIO - Artigos por título
Mostrando ítems 15-34 de 35
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High-Yield Preparation of Exfoliated 1T-MoS2 with SERS Activity
(American Chemical Society, 2019-07-17)[Abstract]: Molybdenum disulfide (MoS2), a promising two-dimensional transition-metal dichalcogenide, presents a challenge in the tuning of its optoelectronic and chemical properties. Herein, we demonstrate an efficient ... -
Hydrogel-Guided, rAAV-Mediated IGF-I Overexpression Enables Long-Term Cartilage Repair and Protection against Perifocal Osteoarthritis in a Large-Animal Full-Thickness Chondral Defect Model at One Year In Vivo
(Wiley-VCH, 2021)[Abstract] The regeneration of focal articular cartilage defects is complicated by the reduced quality of the repair tissue and the potential development of perifocal osteoarthritis (OA). Biomaterial-guided gene therapy ... -
Improved Chondrogenic Differentiation of rAAV SOX9-Modified Human MSCs Seeded in Fibrin-Polyurethane Scaffolds in a Hydrodynamic Environment
(MDPI, 2018)[Abstract] The repair of focal articular cartilage defects remains a problem. Combining gene therapy with tissue engineering approaches using bone marrow-derived mesenchymal stem cells (MSCs) may allow the development of ... -
In Situ Synthesis of Artificial Lipids
(Elsevier, 2022-09-15)[Abstract] Lipids constitute one of the most enigmatic family of biological molecules. Although the importance of lipids as basic units of compartmental structure and energy storage is well-acknowledged, deciphering the ... -
Intrinsic and Selective Activity of Functionalized Carbon Nanotube/Nanocellulose Platforms Against Colon Cancer Cells
(Elsevier, 2022-01-25)[Abstract] Given their large surface area and versatile chemical reactivity, single-walled carbon nanotubes (SWCNTs) are regarded as the basis of new pharmacological complexes. In this study, SWCNTs are chemically ... -
Light-driven, heterogeneous organocatalysts for C–C bond formation toward valuable perfluoroalkylated intermediates
(American Association for the Advancement of Science, 2020-11-11)The favorable exploitation of carbon nitride (CN) materials in photocatalysis for organic synthesis requires the appropriate fine-tuning of the CN structure. Here, we present a deep investigation of the structure/activity ... -
Metal Nanoparticles/MoS2 Surface-Enhanced Raman Scattering- Based Sandwich Immunoassay for α‑Fetoprotein Detection
(American Chemical Society, 2021-02-13)[Abstract]: The detection of cancer biomarkers at an early stage of tumor development is vital for effective diagnosis and treatment of cancer. Current diagnostic tools can often detect cancer only when the biomarker levels ... -
Metal-Free Photocatalysis: Two-Dimensional Nanomaterial Connection toward Advanced Organic Synthesis
(American Chemical Society, 2021-03-21)[Abstract] Two-dimensional (2D) nanostructures are a frontier in materials chemistry as a result of their extraordinary properties. Metal-free 2D nanomaterials possess extra appeal due to their improved cost-effectiveness ... -
Microwave-Induced Covalent Functionalization of Few-Layer Graphene with Arynes under Solvent-Free Conditions
(Royal Society of Chemistry, 2018-07-04)[Abstract]: A non-conventional modification of exfoliated few-layer graphene (FLG) with different arynes under microwave (MW) irradiation and solvent-free conditions is reported. The described approach allows reaching fast, ... -
Non-viral gene delivery to human mesenchymal stem cells: a practical guide towards cell engineering
(BioMed Central, 2023)[Abstract] In recent decades, human mesenchymal stem cells (hMSCs) have gained momentum in the field of cell therapy for treating cartilage and bone injuries. Despite the tri-lineage multipotency, proliferative properties, ... -
Poly(Boc-acryloyl hydrazide): the importance of temperature and RAFT agent degradation on its preparation
(Royal Society of Chemistry, 2019)[Abstract] Poly(acryloyl hydrazide) is a versatile polymer scaffold readily functionalised through post-polymerisation modification with aldehydes to yield polymers for biological applications. However, its polymerisation ... -
Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers
(Royal Society of Chemistry, 2019)[Abstract] Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with a fine-tuned balance between ... -
Polymer-Induced Biofilms for Enhanced Biocatalysis
(Royal Society of Chemistry, 2022-07-21)[Abstract] The intrinsic resilience of biofilms to environmental conditions makes them an attractive platform for biocatalysis, bioremediation, agriculture or consumer health. However, one of the main challenges in these ... -
Rapid Formation of Non-canonical Phospholipid Membranes by Chemoselective Amide-Forming Ligations with Hydroxylamines
(2024)[Abstract] There has been increasing interest in methods to generate synthetic lipid membranes as key constituents of artificial cells or to develop new tools for remodeling membranes in living cells. However, the biosynthesis ... -
Single-Step Functionalization Strategy of Graphene Microtransistor Array with Chemically Modified Aptamers for Biosensing Applications
(Wiley-VCH, 2023-12-10)[Abstract]: Graphene solution-gated field-effect transistors (gSGFETs) offer high potential for chemical and biochemical sensing applications. Among the current trends to improve this technology, the functionalization ... -
Site-Selective and Rewritable Labeling of DNA through Enzymatic, Reversible, and Click Chemistries
(American Chemical Society, 2020)[Abstract] Current methods for bioconjugation rely on the introduction of stable linkers that lack the required versatility to perform sequential functionalizations. However, sequential manipulations are an increasing ... -
Stimuli-Responsive Delivery of Antimicrobial Peptides Using Polyelectrolyte Complexes
(Wiley, 2023)[Abstract] Antimicrobial peptides (AMPs) are antibiotics with the potential to address antimicrobial resistance. However, their translation to the clinic is hampered by issues such as off-target toxicity and low stability ... -
Supramolecular Cyclodextrin-Based Hydrogels for Controlled Gene Delivery
(MDPI, 2019)[Abstract] Controlled delivery of gene transfer vectors is a powerful strategy to enhance the temporal and spatial presentation of therapeutic agents in a defined target. Hydrogels are adapted biomaterials for gene delivery ... -
The Reactivity of Reduced Graphene Depends on Solvation
(IOP Publishing, 2019-02-01)[Abstract] The reactivity of reduced graphene sheets (graphenide), obtained by dissolution of graphite intercalation compounds, in particular KC8, was systemically studied by cova-lent functionalization with 4-fluorobenz ... -
Thermosensitive Hydrogel Based on PEO–PPO–PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno-Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects
(WILEY-VCH, 2020)[Abstract] Advanced biomaterial-guided delivery of gene vectors is an emerging and highly attractive therapeutic solution for targeted articular cartilage repair, allowing for a controlled and minimally invasive delivery ...