Supramolecular Cyclodextrin-Based Hydrogels for Controlled Gene Delivery
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Supramolecular Cyclodextrin-Based Hydrogels for Controlled Gene DeliveryData
2019Cita bibliográfica
Rey-Rico, A.; Cucchiarini, M. Supramolecular Cyclodextrin-Based Hydrogels for Controlled Gene Delivery. Polymers 2019, 11, 514. https://doi.org/10.3390/polym11030514
Resumo
[Abstract] Controlled delivery of gene transfer vectors is a powerful strategy to enhance the temporal and spatial presentation of therapeutic agents in a defined target. Hydrogels are adapted biomaterials for gene delivery capable of acting as a localized depot of genes while maintaining the long term local availability of DNA vectors at a specific location. Supramolecular hydrogels based on cyclodextrins (CDs) have attracted considerable attention as potential biomaterials in a broad range of drug delivery applications. Their unique characteristics of thixotropicity and low cytotoxicity due to their production under mild conditions make them potential candidates to form injectable delivery systems. This work aims to provide an overview of the use of CD-based polypseudorotaxane hydrogels as controlled gene delivery systems for different applications in regenerative medicine.
Palabras chave
Supramolecular hydrogels
Cyclodextrin-based polypseudorotaxane hydrogels
Controlled gene delivery
Nonviral vectors
Viral vectors
Gene transfer
Cyclodextrin-based polypseudorotaxane hydrogels
Controlled gene delivery
Nonviral vectors
Viral vectors
Gene transfer
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Creative Commons Attribution (CC BY) license 4.0