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dc.contributor.authorPiñeiro-Ramil, María
dc.contributor.authorBurguera, Elena F.
dc.contributor.authorHermida-Gómez, Tamara
dc.contributor.authorCaramés, Beatriz
dc.contributor.authorOreiro, Natividad
dc.contributor.authorMeijide-Faílde, Rosa
dc.contributor.authorBlanco García, Francisco J
dc.contributor.authorVaamonde-García, Carlos
dc.date.accessioned2022-04-18T07:43:04Z
dc.date.available2022-04-18T07:43:04Z
dc.date.issued2022-03-25
dc.identifier.citationPiñeiro-Ramil M, Burguera EF, Hermida-Gómez T, Caramés B, Oreiro-Villar N, Meijide-Faílde R, Blanco FJ, Vaamonde-García C. Reduced levels of H₂S in diabetes-associated osteoarthritis are linked to hyperglycaemia, Nrf-2/HO-1 signalling downregulation and chondrocyte dysfunction. Antioxidants (Basel). 2022 Mar 25;11(4):628.es_ES
dc.identifier.issn2076-3921
dc.identifier.urihttp://hdl.handle.net/2183/30471
dc.description.abstract[Abstract] Different findings indicate that type 2 diabetes is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Changes in the balance of hydrogen sulphide (H₂S) are thought to play an important role in the pathogenesis of diabetes and its complications, although its role is still controversial. In this study, we examined the modulation of H₂S levels in serum and chondrocytes from OA diabetic (DB) and non-diabetic (non-DB) patients and in cells under glucose stress, in order to elucidate whether impairment in H₂S-mediated signalling could participate in the onset of DB-related OA. Here, we identified a reduction in H₂S synthesis in the cartilage from OA-DB patients and in cells under glucose stress, which is associated with hyperglycaemia-mediated dysregulation of chondrocyte metabolism. In addition, our results indicate that H₂S is an inductor of the Nrf-2/HO-1 signalling pathway in cartilage, but is also a downstream target of Nrf-2 transcriptional activity. Thereby, impairment of the H₂S/Nrf-2 axis under glucose stress or DB triggers chondrocyte catabolic responses, favouring the disruption of cartilage homeostasis that characterizes OA pathology. Finally, our findings highlight the benefits of the use of exogeneous sources of H₂S in the treatment of DB-OA patients, and warrant future clinical studies.es_ES
dc.description.sponsorshipThis research was funded by grant PI19/01206 from the Fondo de Investigación Sanitaria, integrated in the National Plan for Scientific Program, Development, and Technological Innovation 2013–2016 and funded by the Instituto de Salud Carlos III (ISCIII)-General Subdirection of Assessment and Promotion of Research-European Regional Development Fund (FEDER) “A way of making Europe”, and also by grants ED431B 2020/55 (Grupos con Potencial de Crecemento 2020) and IN607A 2021/7 (Grupos de Referencia Competitiva) from Xunta de Galicia. The study was also supported by the Biomedical Research Network Centre (CIBER), an initiative of ISCIII. C.V.-G. thanks Xunta de Galicia for his postdoctoral contract (grant number ED481D 2017/023)es_ES
dc.description.sponsorshipXunta de Galicia; ED431B 2020/55es_ES
dc.description.sponsorshipXunta de Galicia; IN607A 2021/7es_ES
dc.description.sponsorshipXunta de Galicia; ED481D 2017/023
dc.description.sponsorshipinfo:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI19%2F01206/ES/VALIDACION CLINICA DE NUEVOS BIOMARCADORES PREDICTIVOS DE DIAGNOSTICO Y PRONOSTICO EN ARTROSIS: EL PROYECTO HPP
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.urihttps://doi.org/10.3390/antiox11040628es_ES
dc.rightsCreative Commons Attribution 4.0 International License (CC-BY 4.0)es_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHydrogen sulphidees_ES
dc.subjectOsteoarthritises_ES
dc.subjectType 2 diabeteses_ES
dc.subjectChondrocyteses_ES
dc.subjectInflammationes_ES
dc.subjectNuclear factor-erythroid 2-related factor-2es_ES
dc.subjectHeme oxygenase-1es_ES
dc.titleReduced levels of H₂S in diabetes-associated osteoarthritis are linked to hyperglycaemia, Nrf-2/HO-1 signalling downregulation and chondrocyte dysfunctiones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleAntioxidantses_ES
UDC.volume11es_ES
UDC.issue4es_ES
UDC.startPage628es_ES
dc.identifier.doi10.3390/antiox11040628


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