Association of Accelerated Dynamics of Telomere Sequence Loss in Peripheral Blood Leukocytes With Incident Knee Osteoarthritis in Osteoarthritis Initiative Cohort
Ver/ abrir
Use este enlace para citar
http://hdl.handle.net/2183/28265
A non ser que se indique outra cousa, a licenza do ítem descríbese como Atribución 4.0 Internacional
Coleccións
- INIBIC- REUMA - Artigos [182]
- GI-GIRS - Artigos [86]
Metadatos
Mostrar o rexistro completo do ítemTítulo
Association of Accelerated Dynamics of Telomere Sequence Loss in Peripheral Blood Leukocytes With Incident Knee Osteoarthritis in Osteoarthritis Initiative CohortAutor(es)
Data
2021-08-05Cita bibliográfica
Guillén, R., Otero, F., Mosquera, A. et al. Association of accelerated dynamics of telomere sequence loss in peripheral blood leukocytes with incident knee osteoarthritis in Osteoarthritis Initiative cohort. Sci Rep 11, 15914 (2021). https://doi.org/10.1038/s41598-021-95326-7
Resumo
[Abstract] Osteoarthritis (OA) is a chronic degenerative joint disease, being the main cause of laboral inability. Decreased telomere size in peripheral blood leukocytes (PBL) has been correlated with age-related pathologies, like knee OA. In a dynamic approach, telomere-qPCR was performed to evaluate the relative percentage of PBL telomere loss after a 6-year follow-up, in 281 subjects from the prospective osteoarthritis initiative (OAI) cohort. A radiological Kellgren-Lawrence (KL) grade ≥ 2 was indicative of knee OA. Individuals with knee OA at recruitment (n = 144) showed a higher PBL telomere loss after 6 years than those without knee OA at baseline (n = 137; p = 0.018). Moreover, individuals that developed knee OA during the follow-up (n = 39) exhibited a higher telomere loss compared to those that remained without OA (n = 98; p < 0.001). Logistic regression analysis showed that PBLs telomere loss was not significantly associated with knee OA at recruitment, but behaves as an independent risk factor associated with incidence after follow-up (OR: 1.043; p = 0.041), together with maximum KL grade (OR: 3.627; p = 0.011), body mass index-BMI (OR: 1.252; p < 0.001) and WOMAC-index (OR: 1.247; p = 0.021), at recruitment. The telomere decay in PBLs is faster in individuals with incident knee OA, possibly reflecting a systemic-global accelerated aging that enhances the cartilage degeneration.
Palabras chave
Ageing
Physiology
Rheumatology
Physiology
Rheumatology
Versión do editor
Dereitos
Atribución 4.0 Internacional
ISSN
2045-2322