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dc.contributor.authorMontes, Adriana
dc.contributor.authorPérez-Pampin, Eva
dc.contributor.authorNavarro-Sarabia, Federico
dc.contributor.authorMoreira, Virginia
dc.contributor.authorRodríguez de la Serna, Arturo
dc.contributor.authorMagallanes, Berta
dc.contributor.authorVasilopoulos, Yiannis
dc.contributor.authorSarafidou, Theologia
dc.contributor.authorFernández.Nebro, Antonio
dc.contributor.authorOrdóñez, María del Carmen
dc.contributor.authorNarváez, Javier
dc.contributor.authorCañete, Juan D.
dc.contributor.authorMárquez, Ana
dc.contributor.authorPascual-Salcedo, Dora
dc.contributor.authorJoven, Beatriz
dc.contributor.authorCarreira, Patricia
dc.contributor.authorMoreno-Ramos, Manuel J.
dc.contributor.authorCáliz, Rafael
dc.contributor.authorFerrer, Miguel Ángel
dc.contributor.authorGarcía-Portales, Rosa
dc.contributor.authorBlanco García, Francisco J
dc.contributor.authorMagro, César
dc.contributor.authorRaya, Enrique
dc.contributor.authorValor, Lara
dc.contributor.authorAlegre-Sancho, Juan J.
dc.contributor.authorBalsa, Alejandro
dc.contributor.authorMartín, Javier
dc.contributor.authorPlant, Darren
dc.contributor.authorIsaacs, John
dc.contributor.authorMorgan, Ann W.
dc.contributor.authorBarton, Anne
dc.contributor.authorWilson, Anthony G.
dc.date.accessioned2020-04-06T09:27:58Z
dc.date.available2020-04-06T09:27:58Z
dc.date.issued2015-03-18
dc.identifier.citationMontes A, Pérez-Pampin E, Navarro-Sarabia F, Moreira V, Rodríguez de la Serna A, Magallanes B, et al. Rheumatoid arthritis response to treatment across IgG1 allotype – anti-TNF incompatibility: a case-only study. Arthritis Res Ther. 2015;17(1): 63es_ES
dc.identifier.issn1478-6354
dc.identifier.urihttp://hdl.handle.net/2183/25301
dc.description.abstract[Abstract] INTRODUCTION: We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of these anti-tumor necrosis factor (anti-TNF) antibodies in the treatment of rheumatoid arthritis (RA). METHODS: The G1m genotypes were analyzed in three collections of patients with RA totaling 1037 subjects. The first, used for discovery, comprised 215 Spanish patients. The second and third were successively used for replication. They included 429 British and Greek patients and 393 Spanish and British patients, respectively. Two outcomes were considered: change in the Disease Activity Score in 28 joint (ΔDAS28) and the European League Against Rheumatism (EULAR) response criteria. RESULTS: An association between less response to INX and incompatibility of the G1m1,17 allotype was found in the discovery collection at 6 months of treatment (P = 0.03). This association was confirmed in the replications (P = 0.02 and 0.08, respectively) leading to a global association (P = 0.001) that involved a mean difference in ΔDAS28 of 0.4 units between compatible and incompatible patients (2.3 ± 1.5 in compatible patients vs. 1.9 ± 1.5 in incompatible patients) and an increase in responders and decrease in non-responders according to the EULAR criteria (P = 0.03). A similar association was suggested for patients treated with ADM in the discovery collection, but it was not supported by replication. CONCLUSIONS: Our results suggest that G1m1,17 allotypes are associated with response to INX and could aid improved therapeutic targeting in RA.es_ES
dc.description.sponsorshipInstituto de Salud Carlos III; PI11/01048es_ES
dc.description.sponsorshipInstituto de Salud Carlos III; PI12/01909es_ES
dc.description.sponsorshipInstituto de Salud Carlos III; RD08/0075/0019es_ES
dc.description.sponsorshipInstituto de Salud Carlos III; RD12/0009/0008es_ES
dc.language.isoenges_ES
dc.publisherBioMed Centrales_ES
dc.relation.urihttps://doi.org/10.1186/s13075-015-0571-zes_ES
dc.rightsAtribución 3.0 Españaes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectAdalimumabes_ES
dc.subjectAntirheumatic agentses_ES
dc.subjectArthritis rheumatoides_ES
dc.subjectImmunoglobulin allotypeses_ES
dc.subjectImmunoglobulin Ges_ES
dc.subjectInfliximabes_ES
dc.subjectMolecular sequence dataes_ES
dc.subjectPolymorphismes_ES
dc.subjectTumor necrosis factor-alphaes_ES
dc.subjectSingle nucleotide
dc.titleRheumatoid arthritis response to treatment across IgG1 allotype – anti-TNF incompatibility: a case-only studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleArthritis Research & Therapyes_ES
UDC.volume17es_ES
UDC.issue1es_ES
UDC.startPage63es_ES


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