Leukocyte telomere length in patients with radiographic knee osteoarthritis
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TitleLeukocyte telomere length in patients with radiographic knee osteoarthritis
Mosquera A, Rego-Pérez I, Blanco FJ, Fernández JL. Leukocyte telomere length in patients with radiographic knee osteoarthritis. Environ Mol Mutagen. 2019; 60(3): 298-301
[Abstract] Relative mean telomere sequence amount was determined by quantitative PCR (qPCR) of peripheral blood leukocyte (PBL) samples obtained at recruitment (n = 310) from individuals from the Osteoarthritis (OA) Initiative consortium. Knees were radiologically evaluated according to the Kellgren–Lawrence (KL) score, ranging from 0 to 4, considering a KL grade ≥ 2 as radiographic evidence of OA (n = 124). Telomere size decreased as baseline KL score increased, being significantly shorter in subjects with KL ≥2 (Mann–Whitney U‐test, P < 0.0001). PBL telomere size was also associated with age, hypertension, body mass index (BMI) and waist circumference. Nevertheless, logistic regression analysis showed that PBL telomere size was a consistent risk factor for concurrent knee OA, independent of these health parameters. Shorter PBL telomeres may indicate a premature aging status which enhances chondrocyte senescence and degenerative joint disease.
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