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Oleate prevents palmitate-induced mitochondrial dysfunction in chondrocytes
(Frontiers, 2021-06-15)
[Abstract] The association between obesity and osteoarthritis (OA) in joints not subjected to mechanical overload, together with the relationship between OA and metabolic syndrome, suggests that there are systemic factors ...
Impaired metabolic flexibility in the osteoarthritis process: a study on transmitochondrial cybrids
(MDPI, 2020-03-27)
[Abstract] Osteoarthritis (OA) is the most frequent joint disease; however, the etiopathogenesis is still unclear. Chondrocytes rely primarily on glycolysis to meet cellular energy demand, but studies implicate impaired ...
Mitochondrial biogenesis: a potential therapeutic target for osteoarthritis
(Elsevier, 2020-05-14)
[Abstract] Mitochondrial dysfunction of human articular chondrocytes is considered a hallmark of cartilage degradation and OA pathogenesis. Due to the huge number of cellular processes in which mitochondria is implicated, ...
Mitochondrial DNA from osteoarthritic patients drives functional impairment of mitochondrial activity: a study on transmitochondrial cybrids
(Elsevier, 2022-05)
[Abstract] With the redefinition of osteoarthritis (OA) and the understanding that the joint behaves as an organ, OA is now considered a systemic illness with a low grade of chronic inflammation. Mitochondrial dysfunction ...
Soluble inflammatory mediators of synoviocytes stimulated by monosodium urate crystals induce the production of oxidative stress, pain, and inflammation mediators in chondrocytes
(Springer, 2021-03-16)
[Abstract] We hypothesized that the secretion of inflammatory mediators from synoviocytes affects the chondrocyte homeostasis of articular cartilage. This study was a preliminary attempt to elucidate the molecular mechanisms ...
mtDNA Haplogroup A Enhances the Effect of Obesity on the Risk of Knee OA in a Mexican Population
(Nature, 2022-03-25)
[Abstract] To evaluate the influence of mitochondrial DNA haplogroups on the risk of knee OA in terms of their interaction with obesity, in a population from Mexico. Samples were obtained from (n = 353) knee OA patients ...
Is osteoarthritis a mitochondrial disease?: what is the evidence
(Wolters Kluwer, 2022-01)
[Abstract] Propose of review: To summarize the evidence that suggests that osteoarthritis (OA) is a mitochondrial disease.
Recent findings: Mitochondrial dysfunction together with mtDNA damage could contribute to cartilage ...
Increased synovial immunohistochemistry reactivity of TGF-β1 in erosive peripheral psoriatic arthritis
(BioMed Central, 2023-03-30)
[Abstract] Background: Immune and non-immune cells contribute to the pathology of chronic arthritis, and they can contribute to tissue remodeling and repair as well as disease pathogenesis. The present research aimed to ...