Listar INIBIC- REUMA - Artigos por autor "Vaamonde-García, Carlos"

Mostrando ítems 1-10 de 10

    • Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes 

      Piñeiro-Ramil, María; Flórez-Fernández, Noelia; Ramil-Gómez, Olalla; Torres, María Dolores; Domínguez, Herminia; Blanco García, Francisco J; Meijide-Faílde, Rosa; Vaamonde-García, Carlos (Elsevier, 2022-01-12)
      [Abstract] Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders. Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as ...

    • Effect of balneotherapy in sulfurous water on an in vivo murine model of osteoarthritis 

      Vaamonde-García, Carlos; Vela Anero, Ángela; Hermida Gómez, Tamara; Burguera, Elena F.; Filgueira-Fernández, P.; Goyanes, Noa; Blanco García, Francisco J; Meijide-Faílde, Rosa (Springer, 2019-11-01)
      [Abstract] Osteoarthritis (OA) is a chronic joint disease that results in progressive cartilage destruction and subsequently joint dysfunction. Growing evidence indicates beneficial impact of balneological interventions ...

    • Hydrogen sulfide biosynthesis is impaired in the osteoarthritic joint 

      Burguera, Elena F.; Vela Anero, Ángela; Gato Calvo, Lucía; Vaamonde-García, Carlos; Meijide-Faílde, Rosa; Blanco García, Francisco J (Springer, 2019-11-16)
      [Abstract] Osteoarthritis (OA) is the most common form of arthritis and it is a leading cause of disability in the elderly. Its complete etiology is not known although there are several metabolic, genetic, epigenetic, and ...

    • Intraarticular administration effect of hydrogen sulfide on an in vivo rat model of osteoarthritis 

      Vaamonde-García, Carlos; Burguera, Elena F.; Vela-Anero, Á.; Hermida Gómez, Tamara; Filgueira-Fernández, P.; Fernández-Rodríguez, Jennifer Adriana; Meijide-Faílde, Rosa; Blanco García, Francisco J (MDPI, 2020-10-08)
      [Abstract] Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological ...

    • Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro 

      Vela-Anero, Á.; Hermida Gómez, Tamara; Gato Calvo, Lucía; Vaamonde-García, Carlos; Díaz-Prado, Silvia; Meijide-Faílde, Rosa; Blanco García, Francisco J; Burguera, Elena F. (Elsevier, 2017-08-15)
      [Abstract] Healthy cartilage maintenance relies on an equilibrium among the anabolic and catabolic processes in chondrocytes. With the onset of osteoarthritis (OA), increased interleukin (IL)-1β levels induce an inhibition ...

    • Mitochondrial DNA Impact on Joint Damaged Process in a Conplastic Mouse Model After Being Surgically Induced With Osteoarthritis 

      Scotece, Morena; Rego-Pérez, Ignacio; Lechuga-Vieco, Ana Victoria; Centeno, Alberto; Jiménez-Gómez, María Concepción; Filgueira-Fernández, P.; Vaamonde-García, Carlos; Enríquez, José Antonio; Blanco García, Francisco J (Nature, 2021-04-27)
      [Abstract] It has been suggested that mitochondrial dysfunction and mtDNA variations may contribute to osteoarthritis (OA) pathogenesis. However, the causative link to support this claim is lacking. Here, we surgically-induced ...

    • mtDNA variability determines spontaneous joint aging damage in a conplastic mouse model 

      Scotece, Morena; Vaamonde-García, Carlos; Lechuga-Vieco, Ana Victoria; Centeno Cortés, Alberto; Jiménez Gómez, María Concepción; Filgueira-Fernández, Purificación; Rego-Pérez, Ignacio; Enríquez, José Antonio; Blanco García, Francisco J (Impact Journals, 2022-07-02)
      [Abstract] Mitochondria and mtDNA variations contribute to specific aspects of the aging process. Here, we aimed to investigate the influence of mtDNA variation on joint damage in a model of aging using conplastic mice. A ...

    • Reduced levels of H₂S in diabetes-associated osteoarthritis are linked to hyperglycaemia, Nrf-2/HO-1 signalling downregulation and chondrocyte dysfunction 

      Piñeiro-Ramil, María; Burguera, Elena F.; Hermida-Gómez, Tamara; Caramés, Beatriz; Oreiro, Natividad; Meijide-Faílde, Rosa; Blanco García, Francisco J; Vaamonde-García, Carlos (MDPI, 2022-03-25)
      [Abstract] Different findings indicate that type 2 diabetes is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Changes in the ...

    • Study of Fucoidans as Natural Biomolecules for Therapeutical Applications in Osteoarthritis 

      Vaamonde-García, Carlos; Flórez-Fernández, Noelia; Torres Pérez, María Dolores; Lamas Vázquez, María José; Blanco García, Francisco J; Domínguez, Herminia; Meijide-Faílde, Rosa (Elsevier, 2021-01-26)
      [Abstract] Osteoarthritis (OA) is the most prevalent articular chronic disease. Although, to date there is no cure for OA. Fucoidans, one of the main therapeutic components of brown algae, have emerged as promising molecules ...

    • The mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint 

      Vaamonde-García, Carlos; Loureiro, Jesús; Valcárcel Ares, Marta Noa; Riveiro Naveira, Romina R.; Ramil-Gómez, Olalla; Hermida-Carballo, Laura; Centeno, Alberto; Meijide-Faílde, Rosa; Blanco García, Francisco J; López-Armada, María José (BioMed Central, 2017-06-12)
      [Abstract] Background. Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether ...