Listar INIBIC- REUMA - Artigos por autor "Oreiro, Natividad"
Mostrando ítems 1-20 de 22
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A clinical model including protein biomarkers predicts radiographic knee osteoarthritis: a prospective study using data from the Osteoarthritis Initiative
Lourido Salas, Lucía María; Balboa-Barreiro, Vanesa; Ruiz-Romero, Cristina; Rego-Pérez, Ignacio; Camacho Encina, María; Paz González, Rocío; Calamia, Valentina; Oreiro, Natividad; Nilsson, Peter; Blanco García, Francisco J (Elsevier, 2021-04-30) -
Analysis of endogenous peptides released from osteoarthritic articular cartilage unravels novel pathogenic markers
Fernández-Puente, Patricia; González-Rodríguez, Lucía; Calamia, Valentina; Picchi, Florencia; Lourido Salas, Lucía María; Camacho Encina, María; Oreiro, Natividad; Rocha Loureda, Beatriz; Paz González, Rocío; Marina, Anabel; García, Carlos; Blanco García, Francisco J; Ruiz-Romero, Cristina (American Society for Biochemistry and Molecular Biology (ASBMB), 2019-07-27)[Abstract] Osteoarthritis (OA) is a pathology characterized by the loss of articular cartilage. In this study, we performed a peptidomic strategy to identify endogenous peptides (neopeptides) that are released from human ... -
Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies
Rodríguez-Fontenla, Cristina; Calaza, Manuel; Evangelou, Evangelos; Valdés, Ana M.; Arden, Nigel; Blanco García, Francisco J; Carr, Andrew; Chapman, Kay; Deloukas, Panos; Doherty, Michael; Esko, Tonu; Garcés Aletá, Carlos M.; Gómez-Reino Carnota, Juan J.; Helgadottir, Hafids; Hofman, Albert; Jonsdottir, Ingilef; Kerkhof, Henneke J.M.; Kloppenburg, Margreet; McCaskie, Andrew; Ntzani, Evangelia E.; Ollier, William E.R.; Oreiro, Natividad; Panoutsopoulo, Kalliope; Ralston, Stuart H.; Ramos, Yolande F. M.; Riancho, José A.; Rivadeneira, Fernando; Slagboom, Eline; Styrkarsdottir, Unnur; Thorsteindottir, Unnur; Thorleifsson, Gudmar; Tsezou, Aspasia; Uitterlinden, André G.; Wallis, Gillian A.; Wilkinson, J. Mark; Zhai, Yanyan; Felson, David T.; Ioannidis, John P.A.; Loughlin, John; Metspalu, Andres; Meulenbelt, Ingrid; Stefansson, Kari; van Meurs, Joyce B.; Zeggini, Eleftheria; Spector, Timothy D.; González, Antonio (Wiley, 2013-12-10)[Abstract] Objective: To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA. Methods: A total of 199 ... -
Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes
Díaz-Prado, Silvia; Cicione, Claudia; Muiños-López, Emma; Hermida Gómez, Tamara; Oreiro, Natividad; Fernández-López, Carlos; Blanco García, Francisco J (BioMed Central, 2012-08-12)[Abstract] Background. Osteoarthritis (OA) is a multifactorial disease characterized by destruction of the articular cartilage due to environmental, mechanical and genetic components. The genetics of OA is complex and ... -
Defective chaperone-mediated autophagy is a hallmark of joint disease in patients with knee osteoarthritis
Lorenzo-Gómez, I.; Nogueira Recalde, Uxía; García-Domínguez, C.; Oreiro, Natividad; Lotz, Martin; Pinto-Tasende, José A.; Blanco García, Francisco J; Caramés, Beatriz (Elsevier, 2023-03-08)[Abstract] Objective: Defects in autophagy contribute to joint aging and Osteoarthritis (OA). Identifying specific autophagy types could be useful for developing novel treatments for OA. Design: An autophagy-related ... -
Descripción de la cohorte PROCOAC (PROspective COhort of A Coruña): cohorte prospectiva española para el estudio de la osteoartritis
Oreiro, Natividad; Raga, Ana C.; Rego-Pérez, Ignacio; Pértega-Díaz, Sonia; Silva-Díaz, María T.; Freire, Mercedes; Fernández-López, Carlos; Blanco García, Francisco J (Elsevier, 2020-11-13)[Resumen] Introducción y objetivo. El uso de cohortes de osteoartritis bien caracterizadas es obligatorio para estudiar y profundizar en el conocimiento en esta enfermedad. En España no existe actualmente ninguna cohorte ... -
Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative
Camacho Encina, María; Balboa-Barreiro, Vanesa; Rego-Pérez, Ignacio; Picchi, Florencia; VanDuin, Jennifer; Qiu, Ji; Fuentes, Manuel; Oreiro, Natividad; LaBaer, Joshua; Ruiz-Romero, Cristina; Blanco García, Francisco J (BMJ, 2019-08-30)[Abstract] Objective To find autoantibodies (AAbs) in serum that could be useful to predict incidence of radiographic knee osteoarthritis (KOA). Design A Nucleic-acid Programmable Protein Arrays (NAPPA) platform was ... -
Discovery of circulating proteins associated to knee radiographic osteoarthritis
Lourido Salas, Lucía María; Ayoglu, Burcu; Fernández-Tajes, Juan; Oreiro, Natividad; Henjes, Frauke; Hellström, Cecilia; Schwenk, Jochen M.; Ruiz-Romero, Cristina; Nilsson, Peter; Blanco García, Francisco J (Nature, 2017-03-09)[Abstract] Currently there are no sufficiently sensitive biomarkers able to reflect changes in joint remodelling during osteoarthritis (OA). In this work, we took an affinity proteomic approach to profile serum samples for ... -
Generation and characterization of human induced pluripotent stem cells (iPSCs) from hand osteoarthritis patient-derived fibroblasts
Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Rodríguez-Fernández, Silvia; Oreiro, Natividad; De-Toro, Javier; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (Nature Research, 2020-03-06)[Abstract] Knowledge and research results about hand osteoarthritis (hOA) are limited due to the lack of samples and animal models of the disease. Here, we report the generation of two induced pluripotent stem cell ... -
Higher synovial immunohistochemistry reactivity of IL-17A, Dkk1, and TGF-β1 in patients with early psoriatic arthritis and rheumatoid arthritis could predict the use of biologics
Pinto-Tasende, José A.; Fernández-Moreno, Mercedes; Rego-Pérez, Ignacio; Fernández-López, J. Carlos; Oreiro, Natividad; De-Toro, Javier; Blanco García, Francisco J (MDPI, 2024-04-08)[Abstract] Background: Delay in diagnosis and therapy in patients with arthritis commonly leads to progressive articular damage. The study aimed to investigate the immunohistochemical reactivity of synovial cytokines ... -
Increased synovial immunohistochemistry reactivity of TGF-β1 in erosive peripheral psoriatic arthritis
Pinto-Tasende, José A.; Fernández-Moreno, Mercedes; Vázquez-Mosquera, María E.; Fernández-López, Carlos; Oreiro, Natividad; de-Toro, Javier; Blanco García, Francico J (BioMed Central, 2023-03-30)[Abstract] Background: Immune and non-immune cells contribute to the pathology of chronic arthritis, and they can contribute to tissue remodeling and repair as well as disease pathogenesis. The present research aimed to ... -
Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect
Styrkarsdottir, Unnur; Stefansdottir, Lilja; Thorleifsson, Gudmar; Stefansson, Olafur A.; Saevarsdottir, Saedis; Lund, Sigrun H.; Rafnar, Thorunn; Hoshijima, Kazuyuki; Novak, Kendra; Oreiro, Natividad; Rego-Pérez, Ignacio; Hansen, Channing; Kazmers, Nikolas; Kiemeney, Lambertus A.; Blanco García, Francisco J; Barker, Tyler; Kloppenburg, Margreet; Jurynec, Michel J.; Gudbjartsson, Daniel F.; Jonsson, Helgi; Thorsteinsdottir, Unnur; Stefansson, Kari (BMJ, 2023-03-17)[Abstract] Objectives: Erosive hand osteoarthritis (EHOA) is a severe subset of hand osteoarthritis (OA). It is unclear if EHOA is genetically different from other forms of OA. Sequence variants at ten loci have been ... -
Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis
Fernández-Moreno, Mercedes; Soto-Hermida, Ángel; Pértega-Díaz, Sonia; Oreiro, Natividad; Fernández-López, Carlos; Rego-Pérez, Ignacio; Blanco García, Francisco J (BioMed Central, 2011-11-22)[Abstract] Background: Oxidative stress play a main role in the initiation and progression of the OA disease and leads to the degeneration of mitochondria. To prevent this, the chondrocytes possess a well-coordinated ... -
Mitochondrial DNA (mtDNA) haplogroups influence the progression of knee osteoarthritis: data from the Osteoarthritis Initiative (OAI)
Soto-Hermida, Ángel; Fernández-Moreno, Mercedes; Oreiro, Natividad; Fernández-López, Carlos; Pértega-Díaz, Sonia; Cortés-Pereira, Estefanía; Rego-Pérez, Ignacio; Blanco García, Francisco J (PLoS, 2014-11-12)[Abstract] OBJECTIVE: To evaluate the influence of the mtDNA haplogroups on knee osteoarthritis progression in Osteoarthritis Initiative (OAI) participants through longitudinal data from radiographs and magnetic resonance ... -
Mitochondrial DNA (mtDNA) haplogroups J and H are differentially associated with the methylation status of articular cartilage: potential role in apoptosis and metabolic and developmental processes
Cortés-Pereira, Estefanía; Fernández-Tajes, Juan; Fernández-Moreno, Mercedes; Vázquez-Mosquera, María E.; Relaño, Sara; Ramos-Louro, Paula; Durán-Sotuela, Alejandro; Dalmao-Fernández, Andrea; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (Wiley, 2019-02-12)[Abstract] Objective. To analyze the influence of mitochondrial genome variation on the DNA methylome of articular cartilage. Methods. DNA methylation profiling was performed using data deposited in the NCBI Gene ... -
Mitochondrial DNA haplogroups associated with MRI-detected structural damage in early knee osteoarthritis
Rego-Pérez, Ignacio; Blanco García, Francisco J; Roemer, Frank W.; Guermazi, Ali; Ran, Di; Ashbeck, Erin L.; Fernández Moreno, Mercedes; Oreiro, Natividad; Hannon, Michael J.; Hunter, David J.; Kwoh, Kent (Elsevier, 2018-07-20)[Abstract] Objective: Magnetic resonance imaging (MRI)-detected structural features are associated with increased risk of radiographic osteoarthritis (ROA). Specific mitochondrial DNA (mtDNA) haplogroups have been associated ... -
Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts: a meta-analysis and functional study
Fernández-Moreno, Mercedes; Soto-Hermida, Ángel; Vázquez-Mosquera, María E.; Cortés-Pereira, Estefanía; Relaño, Sara; Hermida Gómez, Tamara; Pértega-Díaz, Sonia; Oreiro, Natividad; Fernández-López, Carlos; Garesse, Rafael; Blanco García, Francisco J; Rego-Pérez, Ignacio (BMJ, 2016-12-05)[Abstract] Objective To evaluate the influence of the mitochondrial DNA (mtDNA) haplogroups in the risk of incident knee osteoarthritis (OA) and to explain the functional consequences of this association to identify potential ... -
Mitochondrial haplogroups define two phenotypes of osteoarthritis
Fernández-Moreno, Mercedes; Soto-Hermida, Ángel; Oreiro, Natividad; Pértega-Díaz, Sonia; Fernández-López, Carlos; Rego-Pérez, Ignacio; Blanco García, Francisco J (Frontiers, 2012-05-11)[Abstract] Objective: To assess a mitochondrion-related phenotype in patients with osteoarthritis (OA). Methods: Serum levels of the following OA-related biomarkers: matrix metalloproteinase-1 (MMP-1); MMP-3; MMP-13; ... -
Mitochondrial Respiratory Chain Dysfunction Modulates Metalloproteases -1, -3 and -13 in Human Normal Chondrocytes in Culture
Cillero-Pastor, B.; Rego-Pérez, Ignacio; Oreiro, Natividad; Fernández-López, Carlos; Blanco García, Francisco J (BioMed Central, 2013-08-09)[Abstract] Background. Mitochondrion has an important role in the osteoarthritis (OA) pathology. We have previously demonstrated that the alteration of the mitochondrial respiratory chain (MRC) contributes to the inflammatory ... -
Optical biomarkers for the diagnosis of osteoarthritis through Raman spectroscopy: radiological and biochemical validation using ex vivo human cartilage samples
Casal-Beiroa, Paula; Balboa-Barreiro, Vanesa; Oreiro, Natividad; Pértega-Díaz, Sonia; Blanco García, Francisco J; Magalhaes, Joana (MDPI, 2021-03-18)[Abstract] Osteoarthritis (OA) is the most common rheumatic disease, characterized by progressive articular cartilage degradation. Raman spectroscopy (RS) has been recently proposed as a label-free tool to detect molecular ...