Listar INIBIC- REUMA - Artigos por autor "González-Álvaro, Isidoro"

Mostrando ítems 1-5 de 5

    • Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case–control study 

      Ferreiro-Iglesias, Aida; Calaza, Manuel; Pérez-Pampin, Eva; López-Longo, J.; Marenco, José L.; Blanco García, Francisco J; Narváez, Javier; Navarro, Federico; Cañete, Juan D.; Rodríguez de la Serna, Arturo; González-Álvaro, Isidoro; Herrero-Beaumont, Gabriel; Pablos, José L.; Balsa, Alejandro; Fernández-Gutiérrez, Benjamín; Cáliz, Rafael; Gómez-Reino, Juan J.; González, Antonio (BioMed Central, 2014-09-27)
      [Abstract] INTRODUCTION: Approximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms ...

    • Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations 

      Márquez, Ana; Kerick, Martin; Zhernakova, Alexandra; Gutiérrez-Achury, Javier; Chen, Wei-Min; Onegut-Gumuscu, Suna; González-Álvaro, Isidoro; Rodríguez-Rodríguez, Luis; Ríos-Fernández, Raquel; González-Gay, Miguel Á.; Mayes, Maureen D.; Raychaudhuri, Soumya; Rich, Stephen S.; Wijmenga, Cisca; Martín, Javier (BMC, 2018-12-20)
      [Abstract] Background. In recent years, research has consistently proven the occurrence of genetic overlap across autoimmune diseases, which supports the existence of common pathogenic mechanisms in autoimmunity. The ...

    • Profile of matrix-remodeling proteinases in osteoarthritis: impact of fibronectin 

      Pérez-García, Selene; Carrión, Mar; Gutiérrez-Cañas, Irene; Villanueva-Romero, Raúl; Castro, David; Martínez, Carmen; González-Álvaro, Isidoro; Blanco García, Francisco J; Juarranz, Yasmina; Gomariz, Rosa P. (MDPI, 2019-12-22)
      [Abstract] The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes ...

    • Urine metabolome profiling of immune-mediated inflammatory diseases 

      Arnald Alonso, Antonio Juliá; Vinaixa, María; Domènech, Eugeni; Fernández-Nebro, Antonio; Cañete, Juan D.; Ferrándiz, Carlos; Tornero, Jesús; Gisbert; Nos, PIlar; Gutiérrez Casbas, Ana; Puig, Lluís; González-Álvaro, Isidoro; Pinto-Tasende, José A.; Blanco, Ricardo; Rodríguez, Miguel A.; Beltrán, Antoni; Correig, Xavier; Marsal, Sara (Springer, 2016-09-08)
      [Abstract] Background, Immune-mediated inflammatory diseases (IMIDs) are a group of complex and prevalent diseases where disease diagnostic and activity monitoring is highly challenging. The determination of the metabolite ...

    • Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis 

      López-Lasanta, María; Juliá, Antonio; Maymó, Joan; Fernández-Gutiérrez, Benjamín; Ureña-Garnica, Inmaculada; Blanco García, Francisco J; Cañete, Juan D.; Alperi-López, Mercedes; Olivé, Alex; Corominas, Héctor; Tornero, Jesús; Erra, Alba; Almirall, Miriam; Palau, Nuria; Ortiz, Ana; Ávila, Gabriela; Rodríguez-Rodríguez, Luis; Alonso, Arnald; Tortosa, Raül; González-Álvaro, Isidoro; Marsal, Sara (BMC, 2015-09-04)
      [Abstract] Introduction. Interleukin-6 (IL-6) cytokine signaling is key in Rheumatoid Arthritis (RA) pathophysiology. Blocking IL-6 receptor (IL6R) has proven to be a highly effective treatment to prevent joint damage. ...