Listar INIBIC- REUMA - Artigos por autor "Calamia, Valentina"
Mostrando ítems 1-11 de 11
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A clinical model including protein biomarkers predicts radiographic knee osteoarthritis: a prospective study using data from the Osteoarthritis Initiative
Lourido Salas, Lucía María; Balboa-Barreiro, Vanesa; Ruiz-Romero, Cristina; Rego-Pérez, Ignacio; Camacho Encina, María; Paz González, Rocío; Calamia, Valentina; Oreiro, Natividad; Nilsson, Peter; Blanco García, Francisco J (Elsevier, 2021-04-30) -
A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine
Calamia, Valentina; Mateos, Jesús; Fernández-Puente, Patricia; Lourido Salas, Lucía María; Rocha Loureda, Beatriz; Fernández-Costa, Carolina; Montell, Eulalia; Vergés, Josep; Ruiz-Romero, Cristina; Blanco García, Francisco J (Nature, 2014-06-10)[Abstract] Osteoarthritis (OA) is the most common age-related rheumatic disease. Chondrocytes play a primary role in mediating cartilage destruction and extracellular matrix (ECM) breakdown, which are main features of the ... -
Analysis of endogenous peptides released from osteoarthritic articular cartilage unravels novel pathogenic markers
Fernández-Puente, Patricia; González-Rodríguez, Lucía; Calamia, Valentina; Picchi, Florencia; Lourido Salas, Lucía María; Camacho Encina, María; Oreiro, Natividad; Rocha Loureda, Beatriz; Paz González, Rocío; Marina, Anabel; García, Carlos; Blanco García, Francisco J; Ruiz-Romero, Cristina (American Society for Biochemistry and Molecular Biology (ASBMB), 2019-07-27)[Abstract] Osteoarthritis (OA) is a pathology characterized by the loss of articular cartilage. In this study, we performed a peptidomic strategy to identify endogenous peptides (neopeptides) that are released from human ... -
Association of the serological status of rheumatoid arthritis patients with two circulating protein biomarkers: a useful tool for precision medicine strategies
Ruiz-Romero, Cristina; Fernández-Puente, Patricia; González, Lucía; Illiano, Anna; Lourido, Lucía; Paz, Rocío; Quaranta, Patricia; Pérez-Pampín, Eva; González, Antonio; Blanco García, Francisco J; Calamia, Valentina (Frontiers, 2022-10-28)[Abstract] Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints and presence of systemic autoantibodies, with a great clinical and molecular heterogeneity. Rheumatoid Factor ... -
Efficacy, Safety and Cost-Effectiveness of Methotrexate, Adalimumab or Their Combination in Non-infectious Non-anterior Uveitis: A Protocol for a Multicentre, Randomised, Parallel Three Arms, Active-Controlled, Phase III Open Label With Blinded Outcome Assessment Study
Rivas, Ana Belén; López-Picado, Amanda; Calamia, Valentina; Carreño, Ester; Cocho, Lidia; Cordero-Coma, Miguel; Fonollosa, Alex; Hernández, Félix M. Francisco; García-Aparicio, Ángel; García-González, Javier; Mondéjar, José Juan; Lojo-Oliveira, Leticia; Martínez-Costa, Llucí; Muñoz, Santiago; Peiteado, Diana; Pinto, José Antonio; Rodríguez-Lozano, Beatriz; Pato, Esperanza; Díaz-Valle, David; Molina, Elena; Tebar, Luis Alberto; Rodríguez-Rodríguez, Luis; CoTHEIA Study Group (BMJ Publishing Group, 2022-03-22)[Abstract] Introduction: Non-infectious uveitis include a heterogeneous group of sight-threatening and incapacitating conditions. Their correct management sometimes requires the use of immunosuppressive drugs (ISDs), ... -
In vitro comprehensive analysis of VA692 a new chemical entity for the treatment of osteoarthritis
Cheleschi, Sara; Calamia, Valentina; Fernández-Moreno, Mercedes; Biava, Mariangela; Giordani, Antonio; Fioravanti, Antonella; Anzini, Maurizio; Blanco García, Francisco J (Elsevier, 2018-08-25)[Abstract] Selective cyclooxigenase (COX)-2 inhibitors were developed to prevent traditional non-steroidal anti-inflammatory drugs (tNSAIDs) gastro-intestinal adverse effects. VA692, a recently disclosed selective COX-2 ... -
Integrative Metabolic Pathway Analysis Reveals Novel Therapeutic Targets in Osteoarthritis
Rocha Loureda, Beatriz; Cillero-Pastor, B.; Eijkel, Gert; Calamia, Valentina; Fernández-Puente, Patricia; Paine, Martin R.L.; Ruiz-Romero, Cristina; Heeren, Ron M.A.; Blanco García, Francisco J (American Society for Biochemistry and Molecular Biology (ASBMB), 2020-01-24)[Abstract] In osteoarthritis (OA), impairment of cartilage regeneration can be related to a defective chondrogenic differentiation of mesenchymal stromal cells (MSCs). Therefore, understanding the proteomic- and ... -
Predictive modeling of therapeutic response to chondroitin sulfate/glucosamine hydrochloride in knee osteoarthritis
Blanco García, Francisco J; Camacho Encina, María; González-Rodríguez, Lucía; Rego-Pérez, Ignacio; Mateos, Jesús; Fernández-Puente, Patricia; Lourido Salas, Lucía María; Rocha Loureda, Beatriz; Picchi, Florencia; Silva-Díaz, María T.; Herrero, Marta; Martínez, Helena; Verges, Josep; Ruiz-Romero, Cristina; Calamia, Valentina (Sage, 2019-08-24)[Abstract] Background: In the present study, we explored potential protein biomarkers useful to predict the therapeutic response of knee osteoarthritis (KOA) patients treated with pharmaceutical grade Chondroitin ... -
Proteome Analysis During Chondrocyte Differentiation in a New Chondrogenesis Model Using Human Umbilical Cord Stroma Mesenchymal Stem Cells
Fuente, Alexandre de la; Mateos, Jesús; Lesende-Rodríguez, Iván; Calamia, Valentina; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Arufe, M.C.; Blanco García, Francisco J (American Society for Biochemistry and Molecular Biology, 2011-10-17)[Abstract] Umbilical cord stroma mesenchymal stem cells were differentiated toward chondrocyte-like cells using a new in vitro model that consists of the random formation of spheroids in a medium supplemented with fetal ... -
Proteomic Analysis of Synovial Fibroblasts and Articular Chondrocytes Co-Cultures Reveals Valuable VIP-Modulated Inflammatory and Degradative Proteins in Osteoarthritis
Pérez-García, Selene; Calamia, Valentina; Hermida Gómez, Tamara; Gutiérrez-Cañas, Irene; Carrión, Mar; Villanueva-Romero, Raúl; Castro, David; Martínez, Carmen; Juarranz, Yasmina; Blanco García, Francisco J; Gomariz, Rosa P. (MDPI, 2021-06-16)[Abstract] Osteoarthritis (OA) is the most common musculoskeletal disorder causing a great disability and a reduction in the quality of life. In OA, articular chondrocytes (AC) and synovial fibroblasts (SF) release ... -
Targeted Phospholipidomic Analysis of Synovial Fluid as a Tool for Osteoarthritis Deep Phenotyping
Rocha Loureda, Beatriz; Illiano, Anna; Calamia, Valentina; Pinto, Gabriella; Amoresano, Angela; Ruiz-Romero, Cristina; Blanco García, Francisco J (Elsevier, 2021-10-20)[Abstract] Objective. The aim of this study was to carry out a targeted phospholipidomic analysis on synovial fluid (SF) from patients with different grades of osteoarthritis (OA) and controls, in order to search for ...