Listar INIBIC- REUMA - Artigos por título
Mostrando ítems 156-175 de 184
-
Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype
(BMC, 2019-11-05)[Abstract] Background Accumulation of senescent cells has been associated with pro-inflammatory effects with deleterious consequences in different human diseases. The purpose of this study was to analyze cell senescence ... -
Sexual dysfunction in ostomized patients: a systematized review
(MDPI, 2021-04-29)[Abstract] The impact of an ostomy has a negative influence on sexuality. Healthcare professionals focus the care on surgery, and consider the sexual life is little relevant to the patient recovery. The aim of this ... -
Single nucleotide polymorphism genes and mitochondrial DNA haplogroups as biomarkers for early prediction of knee osteoarthritis structural progressors: use of supervised machine learning classifiers
(BioMed Central, 2022-09-12)[Abstract] Background. Knee osteoarthritis is the most prevalent chronic musculoskeletal debilitating disease. Current treatments are only symptomatic, and to improve this, we need a robust prediction model to stratify ... -
Soluble inflammatory mediators of synoviocytes stimulated by monosodium urate crystals induce the production of oxidative stress, pain, and inflammation mediators in chondrocytes
(Springer, 2021-03-16)[Abstract] We hypothesized that the secretion of inflammatory mediators from synoviocytes affects the chondrocyte homeostasis of articular cartilage. This study was a preliminary attempt to elucidate the molecular mechanisms ... -
Specific premature epigenetic aging of cartilage in osteoarthritis
(Impact Journals, 2016-09-28)[Abstract] Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, ... -
Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort
(BioMed Central, 2022-11-17)[Abstract] Background. The IMI-APPROACH cohort is an exploratory, 5-centre, 2-year prospective follow-up study of knee osteoarthritis (OA). Aim was to describe baseline multi-tissue semiquantitative MRI evaluation of index ... -
Study of fucoidans as natural biomolecules for therapeutical applications in osteoarthritis
(Elsevier, 2021-01-26)[Abstract] Osteoarthritis (OA) is the most prevalent articular chronic disease. Although, to date there is no cure for OA. Fucoidans, one of the main therapeutic components of brown algae, have emerged as promising molecules ... -
Subcutaneous tanezumab for osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period
(BMJ, 2020-03-31)[Abstract] Objective. Tanezumab, a nerve growth factor inhibitor, was investigated for osteoarthritis (OA) of the hip or knee in a study with 24-week treatment and 24-week safety follow-up. Methods. This double-blind, ... -
Subcutaneous tanezumab for osteoarthritis: is the early improvement in pain and function meaningful and sustained?
(Wiley, 2021-03-16)[Abstract] Background: To evaluate if early improvements in pain and function with subcuta-neous tanezumab are meaningful and sustained over 24 weeks. Methods: Patients with moderate- to- severe osteoarthritis (hip or ... -
Targeted phospholipidomic analysis of synovial fluid as a tool for osteoarthritis deep phenotyping
(Elsevier, 2021-10-20)[Abstract] Objective. The aim of this study was to carry out a targeted phospholipidomic analysis on synovial fluid (SF) from patients with different grades of osteoarthritis (OA) and controls, in order to search for ... -
Test–retest precision and longitudinal cartilage thickness loss in the IMI-APPROACH cohort
(Elsevier, 2022-11-03)[Abstract] Objective. To investigate the test–retest precision and to report the longitudinal change in cartilage thickness, the percentage of knees with progression and the predictive value of the machine-learning-estimated ... -
The addition of albumin improves Schwann cells viability in nerve cryopreservation
(Springer, 2018-04-26)[Abstract] The purpose of the current study was to establish a valid protocol for nerve cryopreservation, and to evaluate if the addition of albumin supposed any advantage in the procedure. We compared a traditional ... -
The association of the lipid profile with knee and hand osteoarthritis severity: the IMI-APPROACH cohort
(Elsevier, 2022-05-27)[Abstract] Objective: To investigate the association of the lipidomic profile with osteoarthritis (OA) severity, considering the outcomes radiographic knee and hand OA, pain and function. Design: We used baseline data ... -
The mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint
(BioMed Central, 2017-06-12)[Abstract] Background. Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether ... -
The phenotype of axial spondyloarthritis: is it dependent on HLA–B27 status?
(Wiley, 2020-02-26)[Abstract] Objective: To describe the radiographic phenotype of axial spondyloarthritis (SpA) according to the presence of HLA-B27. Methods: An international collaboration compared the radiographic phenotype of axial ... -
The role of osmolarity adjusting agents in the regulation of encapsulated cell behavior to provide a safer and more predictable delivery of therapeutics
(Taylor & Francis, 2017-10-27)[Abstract] Transplantation of cells within alginate microspheres has been extensively studied for sustained drug delivery. However, the lack of control over cell behavior represents a major concern regarding the efficacy ... -
Tips and tricks for successfully culturing and adapting human induced pluripotent stem cells
(Cell Press, 2021-12)[Abstract] Reprogramming somatic cells toward pluripotency became possible over a decade ago. Since then, induced pluripotent stem cells (iPSCs) have served as a versatile and powerful tool not only for basic research but ... -
Translation of clinical problems in osteoarthritis into pathophysiological research goals
(BMJ, 2016-05-26)[Abstract] Osteoarthritis (OA) accounts for more disability among the elderly than any other disease and is associated with an increased mortality rate. The prevalence in Europe will rise in the future since this continent ... -
Tratamiento de lesiones del cartílago articular con terapia celular
(Elsevier, 2008-11-13)[Resumen] Las lesiones del cartílago articular que no afectan a la integridad del hueso subcondral no se reparan espontáneamente. El carácter asintomático de estas lesiones propicia la progresiva degeneración articular y ...