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Mitochondrial activity is modulated by TNFα and IL-1β in normal human chondrocyte cells
(Elsevier, 2006-05-05)
[Abstract] Objective. Pro-inflammatory cytokines play an important role in osteoarthritis (OA). In osteoarthritic cartilage, chondrocytes exhibit an alteration in mitochondrial activity. This study analyzes the effect of ...
Lamin A Deregulation in Human Mesenchymal Stem Cells Promotes an Impairment in their Chondrogenic Potential and Imbalance in their Response to Oxidative Stress
(Elsevier, 2013-07-26)
[Abstract] In the present study, we examined the effect of the over-expression of LMNA, or its mutant form progerin (PG), on the mesoderm differentiation potential of mesenchymal stem cells (MSCs) from human umbilical cord ...
Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis
(BioMed Central, 2011-11-22)
[Abstract] Background: Oxidative stress play a main role in the initiation and progression of the OA disease and leads to the degeneration of mitochondria. To prevent this, the chondrocytes possess a well-coordinated ...
Rheumatoid arthritis response to treatment across IgG1 allotype – anti-TNF incompatibility: a case-only study
(BioMed Central, 2015-03-18)
[Abstract] INTRODUCTION:
We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of ...
Impact of prevalence ratios of chondroitin sulfate (CS)- 4 and -6 isomers derived from marine sources in cell proliferation and chondrogenic differentiation processes
(MDPI, 2020-01-31)
[Abstract]
Osteoarthritis is the most prevalent rheumatic disease. During disease progression,
differences have been described in the prevalence of chondroitin sulfate (CS) isomers. Marine
derived-CS present a higher ...
Leukocyte telomere length in patients with radiographic knee osteoarthritis
(Wiley, 2019-11-29)
[Abstract] Relative mean telomere sequence amount was determined by quantitative PCR (qPCR) of peripheral blood leukocyte (PBL) samples obtained at recruitment (n = 310) from individuals from the Osteoarthritis (OA) ...
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways
(Nature, 2019-10-31)
[Abstract] Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous ...
Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype
(BMC, 2019-11-05)
[Abstract] Background
Accumulation of senescent cells has been associated with pro-inflammatory effects with deleterious consequences in different human diseases. The purpose of this study was to analyze cell senescence ...
Is It Time for Epigenetics in Osteoarthritis?
(Wiley, 2014-05-16)
[Abstract] DNA methylation is an epigenetic mechanism of reversible gene regulation which typically results in gene silencing upon hypermethylation in high CpG density regions of promoters (termed CpG islands), and increased ...