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dc.contributor.authorBurguera, Elena F.
dc.contributor.authorMeijide-Faílde, Rosa
dc.contributor.authorBlanco García, Francisco J
dc.date.accessioned2018-12-10T11:17:55Z
dc.date.available2018-12-10T11:17:55Z
dc.date.issued2017
dc.identifier.citationFernández Burguera E, Meijide-Faílde R, Blanco FJ. Hydrogen sulfide and inflammatory joint diseases. Curr Drug Targets. 2017;18(14):1641-1652es_ES
dc.identifier.issn1389-4501
dc.identifier.urihttp://hdl.handle.net/2183/21480
dc.description.abstract[Abstract] Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with important physiologic functions in the brain, vasculature and other organs. Recent studies have found H2S to be a mediator in inflammatory joint diseases. Objective: This review summarizes the recent literature in this area highlighting relevant developments. Conclusions: Several authors have found that H2S exhibited anti-inflammatory, anti-catabolic and/or anti-oxidant effects in rodent models of acute arthritis and in in vitro models using human synoviocytes and articular chondrocytes from RA and OA tissues. The earliest studies used fast-dissolving salts, such as NaSH, but GYY4137, which produces H2S more physiologically, shortly appeared. More recently still, new H2S-forming compounds that target mitochondria have been synthesized. These compounds open exciting opportunities for investigating the role of H2S in cell bioenergetics, typically altered in arthritides. Positive results have also been obtained when H2S is administered as a sulphurous water bath, an option meriting further study. These findings suggest that exogenous supplementation of H2S may provide a viable therapeutic option for these diseases, particularly in OA.es_ES
dc.language.isoenges_ES
dc.publisherBenthames_ES
dc.relation.urihttp://dx.doi.org/10.2174/1389450117666160829112824es_ES
dc.rightsThe published manuscript is avaliable at Eureka Selectes_ES
dc.subjectInflammatory joint diseaseses_ES
dc.subjectRheumatoid arthritises_ES
dc.subjectOsteoarthritises_ES
dc.subjectHydrogen sulfidees_ES
dc.subjectMitochondriaes_ES
dc.subjectSulphurous spring waterses_ES
dc.titleHydrogen sulfide and inflammatory joint diseaseses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleCurrent Drug Targetses_ES
UDC.volume18es_ES
UDC.issue14es_ES
UDC.startPage1641es_ES
UDC.endPage1652es_ES


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