Now showing items 14-18 of 18

    • New insights into molecular mechanisms of sunitinib-associated side effects 

      Aparicio Gallego, Guadalupe; Blanco, Moisés; Figueroa, Angélica; García-Campelo, Rosario; Valladares-Ayerbes, Manuel; Grande Pulido, Enrique; Antón-Aparicio, Luis M. (American Association for Cancer Research, 2011-12)
      [Abstract] The introduction of targeted therapy represents a major advance in the treatment of tumor progression. Targeted agents are a novel therapeutic approach developed to disrupt different cellular signaling pathways. ...
    • Potential role of sugar transporters in cancer and their relationship with anticancer therapy 

      Blanco, Moisés; Figueroa, Angélica; Grande Pulido, Enrique; García Campelo, Rosario; Antón-Aparicio, Luis M. (Hindawi, 2010-06-20)
      [Abstract] Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. ...
    • Radium-223 dichloride: a new paradigm in the treatment of prostate cancer 

      Anido Herranz, Urbano; Fernández Calvo, Ovidio; Afonso Afonso, Francisco Javier; Rodríguez Martínez de Llano, Sofía; Lázaro Quintela, Martín; León Mateos, Luis; Vázquez Estévez, Sergio; Antón-Aparicio, Luis M. (Taylor & Francis, 2015-01-02)
      [Abstract] Radionuclides have been widely used for cancer treatment. Recently, new research about radium-223 dichloride has been conducted in prostate cancer, which reveals that it is the first radiopharmaceutical to ...
    • Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells 

      Antón-Aparicio, Luis M.; Castosa, Raquel; Haz, Mar; Rodríguez, Marta; Blanco, Moisés; Valladares-Ayerbes, Manuel; Figueroa, Angélica (BioMed Central, 2014-07-10)
      [Abstract] Background. Vinflunine (VFL) is a microtubule-targeting drug that suppresses microtubule dynamics, showing anti-metastatic properties both in vitro and in living cancer cells. An increasing body of evidence ...
    • Sunitinib-induced asthenia: from molecular basis to clinical relief 

      Antón-Aparicio, Luis M.; Grande Pulido, Enrique; Aparicio Gallego, Guadalupe (Taylor & Francis, 2011-11-01)
      [Abstract] Asthenia-fatigue syndrome (AFS) is defined as a persistent, subjective sense of tiredness related to cancer or its treatment and greatly impacts quality of life among cancer patients. All tyrosine kinase inhibitors, ...