Now showing items 11-18 of 18

    • Hakai reduces cell-substratum adhesion and increases epithelial cell invasion 

      Rodríguez-Rigueiro, Teresa; Valladares-Ayerbes, Manuel; Haz, Mar; Antón-Aparicio, Luis M.; Figueroa, Angélica (BioMed Central, 2011-11-03)
      [Abstract] Background. The dynamic regulation of cell-cell adhesions is crucial for developmental processes, including tissue formation, differentiation and motility. Adherens junctions are important components of the ...
    • miR-203 regulates cell proliferation through Its influence on Hakai expression 

      Abella Cajigal, Vanessa; Valladares-Ayerbes, Manuel; Rodríguez, Teresa; Haz, Mar; Blanco, Moisés; Tarrío, Nuria; Iglesias, Pilar; Antón-Aparicio, Luis M.; Figueroa, Angélica (PLoS, 2012-12-20)
      Gene expression is potently regulated through the action of microRNAs (miRNAs). Here, we present evidence of a miRNA regulating Hakai protein. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational ...
    • Multiple biomarker tissue arrays: a computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Valladares-Ayerbes, Manuel; Santamarina, Isabel; Antón-Aparicio, Luis M. (BioMed Central, 2012-09-01)
      [Abstract] Background. Many studies have demonstrated genetic and environmental factors that lead to renal cell carcinoma (RCC) and that occur during a protracted period of tumourigenesis. It appears suitable to identify ...
    • New insights into molecular mechanisms of sunitinib-associated side effects 

      Aparicio Gallego, Guadalupe; Blanco, Moisés; Figueroa, Angélica; García-Campelo, Rosario; Valladares-Ayerbes, Manuel; Grande Pulido, Enrique; Antón-Aparicio, Luis M. (American Association for Cancer Research, 2011-12)
      [Abstract] The introduction of targeted therapy represents a major advance in the treatment of tumor progression. Targeted agents are a novel therapeutic approach developed to disrupt different cellular signaling pathways. ...
    • Potential role of sugar transporters in cancer and their relationship with anticancer therapy 

      Blanco, Moisés; Figueroa, Angélica; Grande Pulido, Enrique; García Campelo, Rosario; Antón-Aparicio, Luis M. (Hindawi, 2010-06-20)
      [Abstract] Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. ...
    • Radium-223 dichloride: a new paradigm in the treatment of prostate cancer 

      Anido Herranz, Urbano; Fernández Calvo, Ovidio; Afonso Afonso, Francisco Javier; Rodríguez Martínez de Llano, Sofía; Lázaro Quintela, Martín; León Mateos, Luis; Vázquez Estévez, Sergio; Antón-Aparicio, Luis M. (Taylor & Francis, 2015-01-02)
      [Abstract] Radionuclides have been widely used for cancer treatment. Recently, new research about radium-223 dichloride has been conducted in prostate cancer, which reveals that it is the first radiopharmaceutical to ...
    • Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells 

      Antón-Aparicio, Luis M.; Castosa, Raquel; Haz, Mar; Rodríguez, Marta; Blanco, Moisés; Valladares-Ayerbes, Manuel; Figueroa, Angélica (BioMed Central, 2014-07-10)
      [Abstract] Background. Vinflunine (VFL) is a microtubule-targeting drug that suppresses microtubule dynamics, showing anti-metastatic properties both in vitro and in living cancer cells. An increasing body of evidence ...
    • Sunitinib-induced asthenia: from molecular basis to clinical relief 

      Antón-Aparicio, Luis M.; Grande Pulido, Enrique; Aparicio Gallego, Guadalupe (Taylor & Francis, 2011-11-01)
      [Abstract] Asthenia-fatigue syndrome (AFS) is defined as a persistent, subjective sense of tiredness related to cancer or its treatment and greatly impacts quality of life among cancer patients. All tyrosine kinase inhibitors, ...