Now showing items 1-18 of 18

    • Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer 

      Valladares-Ayerbes, Manuel; Díaz Prado, Silvia; Reboredo, Margarita; Medina Villaamil, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; García Campelo, Rosario; Haz, Mar; Santamarina, Isabel; Antón-Aparicio, Luis M. (Elsevier, 2008)
      [Abstract] Background: Detection of tumor cells in the blood, or minimal deposits in distant organs as bone marrow, could be important to identify cancer patients at high risk of relapse or disease progression. Quantitative ...
    • Potential role of sugar transporters in cancer and their relationship with anticancer therapy 

      Blanco, Moisés; Figueroa, Angélica; Grande Pulido, Enrique; García Campelo, Rosario; Antón-Aparicio, Luis M. (Hindawi, 2010-06-20)
      [Abstract] Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. ...
    • Fructose transporter Glut5 expression in clear renal cell carcinoma 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Valbuena Ruvira, L.; García Campelo, R.; Valladares-Ayerbes, Manuel; Grande Pulido, Enrique; Bolós Fernández, Victoria; Santamarina, Isabel; Antón-Aparicio, Luis M. (Spandidos, 2010-12-10)
      [Abstract] Renal cell carcinomas (RCC) can be subclassified for general purposes into clear cell, papillary cell, chromophobe cell carcinomas and oncocytomas. Other tumours such as collecting duct, medullary, mucinous ...
    • A novel procedure for protein extraction from formalin-fixed paraffin-embedded tissues 

      Rodríguez-Rigueiro, Teresa; Valladares-Ayerbes, Manuel; Haz, Mar; Blanco, Moisés; Aparicio Gallego, Guadalupe; Fernández-Puente, Patricia; Blanco García, Francisco J; Lorenzo-Patiño, María J.; Antón-Aparicio, Luis M.; Figueroa, Angélica (Wiley, 2011-05-18)
      [Abstract] Most of the archived pathological specimens in hospitals are kept as formalin-fixed paraffin-embedded tissues (FFPE) for long-term preservation. Up to now, these samples are only used for immunohistochemistry ...
    • Sunitinib-induced asthenia: from molecular basis to clinical relief 

      Antón-Aparicio, Luis M.; Grande Pulido, Enrique; Aparicio Gallego, Guadalupe (Taylor & Francis, 2011-11-01)
      [Abstract] Asthenia-fatigue syndrome (AFS) is defined as a persistent, subjective sense of tiredness related to cancer or its treatment and greatly impacts quality of life among cancer patients. All tyrosine kinase inhibitors, ...
    • Hakai reduces cell-substratum adhesion and increases epithelial cell invasion 

      Rodríguez-Rigueiro, Teresa; Valladares-Ayerbes, Manuel; Haz, Mar; Antón-Aparicio, Luis M.; Figueroa, Angélica (BioMed Central, 2011-11-03)
      [Abstract] Background. The dynamic regulation of cell-cell adhesions is crucial for developmental processes, including tissue formation, differentiation and motility. Adherens junctions are important components of the ...
    • New insights into molecular mechanisms of sunitinib-associated side effects 

      Aparicio Gallego, Guadalupe; Blanco, Moisés; Figueroa, Angélica; García-Campelo, Rosario; Valladares-Ayerbes, Manuel; Grande Pulido, Enrique; Antón-Aparicio, Luis M. (American Association for Cancer Research, 2011-12)
      [Abstract] The introduction of targeted therapy represents a major advance in the treatment of tumor progression. Targeted agents are a novel therapeutic approach developed to disrupt different cellular signaling pathways. ...
    • Biological influence of Hakai in cancer: a 10-year review 

      Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel; Blanco, Moisés; Alonso, Guillermo; Figueroa, Angélica (Springer, 2012-02-19)
      [Abstract] In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the ...
    • Circulating microRNAs: molecular microsensors in gastrointestinal cancer 

      Blanco, Moisés; Calvo, Lourdes; Figueroa, Angélica; Haz, Mar; Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel (MPDI, 2012-07-09)
      [Abstract] MicroRNAs (miRNAs) are small molecules of single strand non-coding RNAs, which are able to regulate gene expression. miRNAs have been involved in multiple cellular processes, such as proliferation, apoptosis and ...
    • Multiple biomarker tissue arrays: a computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Valladares-Ayerbes, Manuel; Santamarina, Isabel; Antón-Aparicio, Luis M. (BioMed Central, 2012-09-01)
      [Abstract] Background. Many studies have demonstrated genetic and environmental factors that lead to renal cell carcinoma (RCC) and that occur during a protracted period of tumourigenesis. It appears suitable to identify ...
    • Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cancer 

      Valladares-Ayerbes, Manuel; Reboredo, Margarita; Medina Villaamil, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; Haz, Mar; Santamarina, Isabel; Blanco, Moisés; Fernández-Tajes, Juan; Quindós-Varela, María; Carral, Alberto; Figueroa, Angélica; Antón-Aparicio, Luis M.; Calvo, Lourdes (BioMed Central, 2012-09-06)
      [Abstract] Background. MicroRNAs are aberrantly expressed and correlate with tumourigenesis and the progression of solid tumours. The miR-200 family determines the epithelial phenotype of cancer cells and regulates ...
    • Crossing paths in Human Renal Cell Carcinoma (hRCC) 

      Aparicio Gallego, Guadalupe; Medina Villaamil, Vanessa; Grande Pulido, Enrique; Santamarina, Isabel; Antón-Aparicio, Luis M. (MDPI, 2012-10-05)
      [Abstract] Historically, cell-signaling pathways have been studied as the compilation of isolated elements into a unique cascade that transmits extracellular stimuli to the tumor cell nucleus. Today, growing evidence ...
    • miR-203 regulates cell proliferation through Its influence on Hakai expression 

      Abella Cajigal, Vanessa; Valladares-Ayerbes, Manuel; Rodríguez, Teresa; Haz, Mar; Blanco, Moisés; Tarrío, Nuria; Iglesias, Pilar; Antón-Aparicio, Luis M.; Figueroa, Angélica (PLoS, 2012-12-20)
      Gene expression is potently regulated through the action of microRNAs (miRNAs). Here, we present evidence of a miRNA regulating Hakai protein. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational ...
    • Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer 

      Blanco, Moisés; Tarrío, Nuria; Reboredo, Margarita; Haz, Mar; García, Jorge; Quindós-Varela, María; Figueroa, Angélica; Antón-Aparicio, Luis M.; Calvo, Lourdes; Valladares-Ayerbes, Manuel (Future Science, 2014-06-20)
      [Abstract] Aim: To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also ...
    • Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells 

      Antón-Aparicio, Luis M.; Castosa, Raquel; Haz, Mar; Rodríguez, Marta; Blanco, Moisés; Valladares-Ayerbes, Manuel; Figueroa, Angélica (BioMed Central, 2014-07-10)
      [Abstract] Background. Vinflunine (VFL) is a microtubule-targeting drug that suppresses microtubule dynamics, showing anti-metastatic properties both in vitro and in living cancer cells. An increasing body of evidence ...
    • Circulating miR-200c and miR-141 and outcomes in patients with breast cancer 

      Antolín, Silvia; Calvo, Lourdes; Blanco, Moisés; Paz Santiago, María; Lorenzo-Patiño, María J.; Haz, Mar; Santamarina, Isabel; Figueroa, Angélica; Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel (BioMed Central, 2015)
      [Abstract] Background. The deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis. We hypothesize the deregulation of miR-200c/miR-141 ...
    • Clinical implications of epithelial cell plasticity in cancer progression 

      Antón-Aparicio, Luis M.; Blanco, Moisés; Castosa, Raquel; Concha, Ángel; Valladares-Ayerbes, Manuel; Calvo, Lourdes; Figueroa, Angélica (Elsevier, 2015)
      [Abstract] In the last few years, the role of epithelial cell plasticity in cancer biology research has gained increasing attention. This concept refers to the ability of the epithelial cells to dynamically switch between ...
    • Radium-223 dichloride: a new paradigm in the treatment of prostate cancer 

      Anido Herranz, Urbano; Fernández Calvo, Ovidio; Afonso Afonso, Francisco Javier; Rodríguez Martínez de Llano, Sofía; Lázaro Quintela, Martín; León Mateos, Luis; Vázquez Estévez, Sergio; Antón-Aparicio, Luis M. (Taylor & Francis, 2015-01-02)
      [Abstract] Radionuclides have been widely used for cancer treatment. Recently, new research about radium-223 dichloride has been conducted in prostate cancer, which reveals that it is the first radiopharmaceutical to ...