Hedgehog signalling as a target in cancer stem cells
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Hedgehog signalling as a target in cancer stem cellsDate
2009Citation
Medina V, Calvo MB, Díaz-Prado S, Espada J. Hedgehog signalling as a target in cancer stem cells. Clin Transl Oncol. 2009;11(4):199-207
Abstract
[Abstract] Hedgehog (Hh) is one of the most important signalling pathways. Together with the Wnt, TGF-β/BMP and Notch pathways, it is involved in both embryonic development and adult tissue homeostasis. This is because Hh plays a central role in the proliferative control and differentiation of both embryonic stem cells and adult stem cells. In this way, an alteration in the Hh pathway, either by misexpression of components of that pathway or by changes in the expression of other cellular components that interfere with the Hh signalling system, may trigger the development of several types of cancer. This occurs because normal stem cells or their intermediaries toward differentiated mature cells are not part of the normal proliferative/differentiation balance and begin to expand without control, triggering the generation of the so-called cancer stem cells. In this review, we will focus on the molecular aspects and the role of Hh signalling in normal tissues and in tumour development.
Keywords
Hh (Hedgehog)
Smoothened (Smo)
Patched (Ptc)
Gli
Cancer
Cancer stem cells
Smoothened (Smo)
Patched (Ptc)
Gli
Cancer
Cancer stem cells
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The final publication is avaliable at Springer Link
ISSN
1699-048X
1578-195X
1578-195X