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dc.contributor.authorMedina Villaamil, Vanessa
dc.contributor.authorBlanco, Moisés
dc.contributor.authorDíaz-Prado, Silvia
dc.contributor.authorEspada, Jesús
dc.date.accessioned2016-11-30T10:45:46Z
dc.date.available2016-11-30T10:45:46Z
dc.date.issued2009
dc.identifier.citationMedina V, Calvo MB, Díaz-Prado S, Espada J. Hedgehog signalling as a target in cancer stem cells. Clin Transl Oncol. 2009;11(4):199-207es_ES
dc.identifier.issn1699-048X
dc.identifier.issn1578-195X
dc.identifier.urihttp://hdl.handle.net/2183/17648
dc.description.abstract[Abstract] Hedgehog (Hh) is one of the most important signalling pathways. Together with the Wnt, TGF-β/BMP and Notch pathways, it is involved in both embryonic development and adult tissue homeostasis. This is because Hh plays a central role in the proliferative control and differentiation of both embryonic stem cells and adult stem cells. In this way, an alteration in the Hh pathway, either by misexpression of components of that pathway or by changes in the expression of other cellular components that interfere with the Hh signalling system, may trigger the development of several types of cancer. This occurs because normal stem cells or their intermediaries toward differentiated mature cells are not part of the normal proliferative/differentiation balance and begin to expand without control, triggering the generation of the so-called cancer stem cells. In this review, we will focus on the molecular aspects and the role of Hh signalling in normal tissues and in tumour development.es_ES
dc.language.isoenges_ES
dc.publisherSpirngeres_ES
dc.relation.urihttp://dx.doi.org/10.1007/s12094-009-0341-yes_ES
dc.rightsThe final publication is avaliable at Springer Linkes_ES
dc.subjectHh (Hedgehog)es_ES
dc.subjectSmoothened (Smo)es_ES
dc.subjectPatched (Ptc)es_ES
dc.subjectGlies_ES
dc.subjectCanceres_ES
dc.subjectCancer stem cellses_ES
dc.titleHedgehog signalling as a target in cancer stem cellses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleClinical and Translational Oncologyes_ES
UDC.volume11es_ES
UDC.issue4es_ES
UDC.startPage199es_ES
UDC.endPage207es_ES


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