Listar INIBIC-ICATC - Artigos por autor "Doménech, Nieves"

Mostrando ítems 1-8 de 8

    • Analysis of mitochondrial proteins in the surviving myocardium after ischemia identifies mitochondrial pyruvate carrier expression as possible mediator of tissue 

      Fernández Caggiano, Mariana; Prysyazhna, Oleksandra; Barallobre-Barreiro, Javier; Calviño Santos, Ramón; Aldama López, Guillermo; Crespo-Leiro, María Generosa; Eaton, Philip; Doménech, Nieves (American Society for Biochemistry and Molecular Biology, 2016-01-01)

    • Cardiac Protection Induced by Urocortin-2 Enables the Regulation of Apoptosis and Fibrosis After Ischemia and Reperfusion Involving miR-29a Modulation 

      Mayoral-González, Isabel; Calderón-Sánchez, Eva M.; Galeano-Otero, Isabel; Martín-Bórnez, Marta; Gutiérrez-Carretero, Encarnación; Fernández-Velasco, María; Doménech, Nieves; Crespo-Leiro, María Generosa; Gómez, Ana María; Ordoñez-Fernández, Antonio; Hmadcha, Abdelkrim; Smani, Tarik (Elsevier, 2022-01-28)
      [Abstract] Urocortin-2 (Ucn-2) has demonstrated cardioprotective actions against myocardial ischemia-reperfusion (I/R) injuries. Herein, we explored the protective role of Ucn-2 through microRNAs (miRNAs) post-transcriptional ...

    • Circulating Galectin-3 Following Heart Transplant: Long-term Dynamics and Prognostic Value 

      Suárez-Fuentetaja, Natalia; Barge-Caballero, Eduardo; Bayés-Genís, Antoni; Doménech, Nieves; Moreda-Santamaría, Lucía; Paniagua-Martín, María J.; Barge-Caballero, Gonzalo; Couto-Mallón, David; Solla-Buceta, Miguel; Estévez-Cid, Francisco; Cuenca-Castillo, José J.; Pombo-Otero, Jorge; Grille-Cancela, Zulaika; Blanco-Canosa, Paula; Muñiz, Javier; Vázquez-Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Elsevier, 2018-11-23)
      [Abstract] Introduction and objectives: Circulating galectin-3 (Gal-3) is elevated and significantly correlates with all-cause and cardiovascular mortality in patients with heart failure. However, the relationship between ...

    • Extracellular Matrix in Heart Failure: Role of ADAMTS5 in Proteoglycan Remodeling 

      Barallobre-Barreiro, Javier; Radovits, Tamás; Fava, Marika; Mayr, Ursula; Lin, Wen-Yu; Ermolaeva, Elizaveta; Martínez-López, Diego; Lindberg, Eric L.; Duregotti, Elisa; Daróczi, László; Hasman, Maria; Schmidt, Lukas E.; Singh, Bhawana; Lu, Ruifang; Baig, Ferheen; Siedlar, Aleksandra Malgorzata; Cuello, Friederike; Catiborg, Norman; Theofilatos, Konstantinos; Shah, Ajay M.; Crespo-Leiro, María Generosa; Doménech, Nieves; Hübner, Norbert; Merkely, Béla; Mayr, Manuel (American Heart Association, 2021-11-22)
      [Abstract] Background: Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF). Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disintegrin and metalloproteinase ...

    • Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population 

      Fernández Caggiano, Mariana; Barallobre-Barreiro, Javier; Rego-Pérez, Ignacio; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Grille Cancela, Zulaika; Blanco García, Francisco J; Doménech, Nieves (Elsevier, 2013-03-23)
      [Abstract] Idiopathic dilated cardiomyopathy (IDC) is a structural heart disease with strong genetic background. The different single nucleotide polymorphisms (SNPs) that constitute mitochondrial haplogroups could play an ...

    • Mitochondrial Pyruvate Carrier Abundance Mediates Pathological Cardiac Hypertrophy 

      Fernández-Caggiano, Mariana; Kamynina, Alisa; Francois, Asvi A.; Prysyazhna, Oleksandra; Eykyn, Thomas R.; Krasemann, Susanne; Crespo-Leiro, María Generosa; García-Vieites, M.; Bianchi, Katiuscia; Morales, Valle; Doménech, Nieves; Eaton, Philip (Springer Nature, 2020-10-26)
      [Abstract] Cardiomyocytes rely on metabolic substrates, not only to fuel cardiac output, but also for growth and remodelling during stress. Here we show that mitochondrial pyruvate carrier (MPC) abundance mediates ...

    • Role of NOD1 in heart failure progression via regulation of Ca2+ handling 

      Val-Blasco, Almudena; Piedras, María José; Ruiz-Hurtado, Gema; Suárez-Fuentetaja, Natalia; Prieto, Patricia; González-Ramos, Silvia; Gómez-Hurtado, Nieves; Delgado, Carmen; Pereira, Laetitia; Benito, Gemma; Zaragoza, Carlos; Doménech, Nieves; Crespo-Leiro, María Generosa; Vázquez-Echeverri, Daniel; Núñez, Gabriel; López-Collazo, Eduardo; Boscá, Lisardo; Fernández-Velasco, María (Elsevier para American College of Cardiology Foundation, 2017-01-23)

    • Specialized proresolving mediators protect against experimental autoimmune myocarditis by modulating Ca2+ handling and NRF2 activation 

      Val-Blasco, Almudena; Prieto, Patricia; Íñigo Jaén, Rafael; Gil-Fernández, Marta; Pajares, Marta; Doménech, Nieves; Terrón, Verónica; Tamayo, María; Jorge, Inmaculada; Vázquez, Jesús; Bueno-Sen, Andrea; Vallejo-Cremades, María Teresa; Pombo-Otero, Jorge; Sánchez-García, Sergio; Ruiz-Hurtado, Gema; Gómez, Ana María; Zaragoza, Carlos; Crespo-Leiro, María Generosa; López-Collado, Eduardo; Cuadrado, Antonio; Delgado, Carmen; Boscá, Lisardo; Fernández-Velasco, María (Elsevier, 2022-05-18)
      [Abstract] Specialized proresolving mediators and, in particular, 5(S), (6)R, 7-trihydroxyheptanoic acid methyl ester (BML-111) emerge as new therapeutic tools to prevent cardiac dysfunction and deleterious cardiac damage ...