Now showing items 28-47 of 102

    • Effect of Age on Pro-Inflammatory miRNAs Contained in Mesenchymal Stem Cell-Derived Extracellular Vesicles 

      Fafián Labora, Juan Antonio; Lesende-Rodríguez, Iván; Fernández-Pernas, Pablo; Sangiao-Alvarellos, Susana; Monserrat, Lorenzo; Arntz, O.J.; Van de Loo, F.J.; Mateos, Jesús; Arufe, M.C. (Nature, 2017-03-06)
      [Abstract] Stem cells possess significant age-dependent differences in their immune-response profile. These differences were analysed by Next-Generation Sequencing of six age groups from bone marrow mesenchymal stem cells. ...
    • Effect of balneotherapy in sulfurous water on an in vivo murine model of osteoarthritis 

      Vaamonde-García, Carlos; Vela Anero, Ángela; Hermida Gómez, Tamara; Burguera, Elena F.; Filgueira-Fernández, P.; Goyanes, Noa; Blanco García, Francisco J; Meijide-Faílde, Rosa (Springer, 2019-11-01)
      [Abstract] Osteoarthritis (OA) is a chronic joint disease that results in progressive cartilage destruction and subsequently joint dysfunction. Growing evidence indicates beneficial impact of balneological interventions ...
    • Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes 

      Burguera, Elena F.; Vela-Anero, Á.; Magalhaes, J.; Meijide-Faílde, Rosa; Blanco García, Francisco J (Elsevier, 2014-07)
      [Abstract] Objective. Hydrogen sulfide (H2S), the third gasotransmitter together with NO and CO, is emerging as a regulator of inflammation. To test if it might offer therapeutic value in the treatment of osteoarthritis ...
    • Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation potential 

      Cicione, Claudia; Muiños-López, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Hindawi, 2013-06-30)
      [Abstract] Background. The interests in mesenchymal stem cells (MSCs) and their application in cell therapy have resulted in a better understanding of the basic biology of these cells. Recently hypoxia has been indicated ...
    • Epidemiology of traumatic spinal cord injury in Galicia, Spain: trends over a 20-year period 

      Montoto-Marqués, A.; Ferreiro-Velasco, M.E.; Salvador-de-la-Barrera, S.; Balboa-Barreiro, Vanesa; Rodríguez-Sotillo, A.; Meijide-Faílde, Rosa (Nature, 2017-02-14)
      [Abstract] Study design: Observational study with prospective and retrospective monitoring. Objective: To describe the epidemiological and demographic characteristics of traumatic spinal cord injury (TSCI), and to analyze ...
    • Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias 

      Díaz-Prado, Silvia; López Cedrún, José Luis; Luaces Rey, Ramón; Medina Villaamil, Vanessa; Álvarez García, Augusto; Valladares-Ayerbes, Manuel; Antón-Aparicio, Luis M. (Elsevier, 2010-07-01)
      [Abstract] Objective. Identify candidate SEBs (surrogate endpoint biomarkers) for premalignant trends in head and neck mucosa. Study design. Study, by qPCR (quantitative real-time polymerase chain reaction), the expression ...
    • Evaluation of Plakophilin-3 mRNA as a biomarker for detection of circulating tumor cells in gastrointestinal cancer patients 

      Valladares-Ayerbes, Manuel; Díaz-Prado, Silvia; Reboredo, Margarita; Medina, Vanessa; Lorenzo-Patiño, María J.; Iglesias-Díaz, Pilar; Haz, Mar; Pértega-Díaz, Sonia; Santamarina, Isabel; Blanco, Moisés; Quindós-Varela, María; Figueroa, Angélica; Antón-Aparicio, Luis M. (American Association for Cancer Research, 2010-05-25)
      [Abstract] Background: This study aims to assess Plakophilin-3 (PKP3) as a surrogate biomarker of circulating tumor cells in patients with gastrointestinal cancer. Methods: The primary aim is to estimate the diagnostic ...
    • Evaluation of the adenocarcinoma-associated gene AGR2 and the intestinal stem cell marker LGR5 as biomarkers in colorectal cancer 

      Valladares-Ayerbes, Manuel; Blanco, Moisés; Reboredo, Margarita; Lorenzo-Patiño, María J.; Iglesias-Díaz, Pilar; Haz, Mar; Díaz-Prado, Silvia; Medina, Vanessa; Santamarina, Isabel; Pértega-Díaz, Sonia; Figueroa, Angélica; Antón-Aparicio, Luis M. (MDPI, 2012-04-05)
      [Abstract] We aim to estimate the diagnostic performances of anterior gradient homolog-2 (AGR2) and Leucine-rich repeat-containing-G-protein-coupled receptor 5 (LGR5) in peripheral blood (PB) as mRNA biomarkers in colorectal ...
    • Exploring the remission concept in rheumatoid arthritis with patients and rheumatologists: time for a new approach? 

      Acebes, Carlos; Andreu, José Luis; Balsa, Alejandro; Batlle, Enrique; De-Toro, Javier; García Llorente, Francisco; Hernández, María Victoria; Fernández-Gutiérrez, Benjamín; Hidalgo-Calleja, Cristina; Mayordomo, Lucía; Naredo, Esperanza; Narváez, Francisco Javier; Ortiz, Ana M.; Pablos, José Luis; Pérez-Sandoval, Trinidad; Rodríguez-Lozano, Carlos; Sánchez-Pernaute, Olga; Usón, Jacqueline; Negrón, José Bernardo; Loza, Estíbaliz; Carmona, Loreto; Gómez Castro, Susana; Montoro Álvarez, María (Clinical and Experimental Rheumatology, 2017-09)
      [Abstract] Objectives: To explore the remission concept in rheumatoid arthritis (RA) and to compare remission definitions and related concepts between rheumatologists and patients with the purpose of identifying ...
    • Expression of Wnt gene family and frizzled receptors in head and neck squamous cell carcinomas 

      Díaz-Prado, Silvia; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Blanco, Moisés; López Cedrún, José Luis; Sironvalle Soliva, Sheila; Valladares-Ayerbes, Manuel; García Campelo, Rosario; Antón-Aparicio, Luis M. (Spirnger, 2009)
      [Abstract] Genes of the Wnt and Frizzled class, expressed in HNSCC tissue and cell lines, have an established role in cell morphogenesis and differentiation, and also they have oncogenic properties. We studied Wnt and Fz ...
    • Extremophilic cyanobacteria from thermo-mineral springs of spas in Atlantic environments 

      López-Rodríguez, M. Carmen; Asencio, Antonia D.; Meijide-Faílde, Rosa; Torres, Enrique (Taylor & Francis, 2022-04-12)
      [Abstract] The species composition of cyanobacteria assemblages was studied in six thermo-mineral springs of spas in Atlantic environments of Galicia (NW Spain). Two are considered hot (Ta ≥ 40 °C), two intermediate (Ta ...
    • Gene expression and functional comparison between multipotential stromal cells from lateral and medial condyles of knee osteoarthritis patients 

      Sanjurjo-Rodríguez, Clara; Baboolal, Thomas G.; Burska, Agata N.; Ponchel, Frederique; El-Jawhari, Jehan J.; Pandit, Hemant; McGonagle, Dennis; Jones, Elena (Nature Publishing Group, 2019-06-29)
      [Abstract] Osteoarthritis (OA) is the most common degenerative joint disorder. Multipotential stromal cells (MSCs) have a crucial role in joint repair, but how OA severity affects their characteristics remains unknown. ...
    • Gene Expression Signatures of Synovial Fluid Multipotent Stromal Cells in Advanced Knee Osteoarthritis and Following Knee Joint Distraction 

      Sanjurjo-Rodríguez, Clara; Altaie, Ala; Mastbergen, Simon; Baboolal, Thomas G.; Welting, Tim; Lafeber, Floris; Pandit, Hemant; McGonagle, Dennis; Jones, Elena (Frontiers Media S.A., 2020-10-14)
      [Abstract] Osteoarthritis (OA) is the most common musculoskeletal disorder. Although joint replacement remains the standard of care for knee OA patients, knee joint distraction (KJD), which works by temporarily off-loading ...
    • Generation and Characterization of Human Induced Pluripotent Stem Cells (iPSCs) From Hand Osteoarthritis Patient-Derived Fibroblasts 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Rodríguez-Fernández, Silvia; Oreiro, Natividad; De-Toro, Javier; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (Nature Research, 2020-03-06)
      [Abstract] Knowledge and research results about hand osteoarthritis (hOA) are limited due to the lack of samples and animal models of the disease. Here, we report the generation of two induced pluripotent stem cell ...
    • Generation of a human control iPS cell line (ESi080‐A) from a donor with no rheumatic diseases 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Rodríguez-Fernández, Silvia; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (Elsevier, 2020-03)
      [Abstract] Here, we report the establishment of the human iPS cell line N1-FiPS4F#7 generated from skin cells of a patient with no rheumatic diseases, thus obtaining an appropriate control iPS cell line for researchers ...
    • Generation of mesenchymal cell lines derived from aged donors 

      Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (MDPI, 2021-10-01)
      [Abstract] Background: Mesenchymal stromal cells (MSCs) have the capacity for self-renewal and multi-differentiation, and for this reason they are considered a potential cellular source in regenerative medicine of cartilage ...
    • Genome Wide CRISPR/Cas9 Screen Identifies the Coagulation Factor IX (F9) as a Regulator of Senescence 

      Carpintero-Fernández, Paula; Borghesan, Michela; Eleftheriadou, Olga; Pan-Castillo, Belén; Fafián Labora, Juan Antonio; Mitchell, Tom P.; Yuste, Alejandro; Ogrunc, Muge; Nightingale, Thomas D.; Mayán, María; O'Loghlen, Ana (Nature, 2022-02-19)
      [Abstract] During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce ...
    • Global DNA Methylation in Dental Implant Failure Due to Peri-Implantitis: An Exploratory Clinical Pilot Study 

      Khouly, Ismael; Pardiñas López, Simón; Díaz-Prado, Silvia; Ferrantino, Luca; Kalm, Josephine; Larsson, Lena; Asa'ad, Farah (MDPI, 2022-01-17)
      [Abstract] Background: Peri-implantitis (PIT) is highly prevalent in patients with dental implants and is a challenging condition to treat due to the limited outcomes reported for non-surgical and surgical therapies. ...
    • Healthcare experience among patients with type 2 diabetes: A cross-sectional survey using the IEXPAC tool 

      Orozco-Beltrán, Domingo; Artola-Menéndez, Sara; Hormigo-Pozo, Antonio; Cararach-Salami, Daniel; Alonso-Jerez, José Luis; Álvaro-Grande, Epifanio; Villalibre-Arias, Covadonga; De-Toro, Javier; Galindo-Puerto, María José; Marín-Jiménez, Ignacio; Gómez-García, Antón; Ledesma-Rodríguez, Rocío; Fernández, Gonzalo; Ferreira de Campos, Karine (Wiley, 2021-02-15)
      [Abstract] Aim: To assess the experience with health care among patients with type 2 diabetes (T2DM) and to evaluate patients' demographic variables and healthcare-related characteristics which may affect their ...
    • Healthcare experience and their relationship with demographic, disease and healthcare-related variables: a cross-sectional survey of patients with chronic diseases using the IEXPAC scale. 

      Orozco-Beltrán, Domingo; De-Toro, Javier; Galindo, María J.; Marín-Jiménez, Ignacio; Casellas, Francesc; Fuster-RuizdeApodaca, María J.; García-Vivar, María L.; Hormigo-Pozo, Antonio; Guilabert, Mercedes; Sánchez-Vega, Nuria; Fernández, Gonzalo; Cea-Calvo, Luis (Springer, 2018-11-15)
      [Abstract] BACKGROUND: Patient experience is acknowledged as a principal aspect of quality healthcare delivery, and it has implications with regard to outcomes. OBJECTIVES: Our objective was to evaluate the healthcare ...